AiPD: Autoinhibited Protein Database

Q9NWU2

Gene name	GID8
Protein name	Glucose-induced degradation protein 8 homolog
Names	Two hybrid-associated protein 1 with RanBPM, Twa1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54994
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-41 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9NWU2

Entry ID	Method	Resolution	Chain	Position	Source
7NSC	EM	330 A	H	1-228	PDB
AF-Q9NWU2-F1	Predicted				AlphaFoldDB

109 variants for Q9NWU2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA317312196 rs979386067	4	A>T		No	ClinGen TOPMed gnomAD
rs900288802 CA317312198	7	P>S		No	ClinGen Ensembl
CA317312209 rs953370389	8	D>A		No	ClinGen TOPMed
CA9952546 rs560888977	8	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531659540 CA9952547	11	T>M		No	ClinGen 1000Genomes ExAC gnomAD
CA9952551 rs746614662	13	D>E		No	ClinGen ExAC gnomAD
rs779875971 CA9952550	13	D>Y		No	ClinGen ExAC gnomAD
rs776479946 CA9952553	16	M>I		No	ClinGen ExAC gnomAD
CA409587045 rs1238359160	20	N>D		No	ClinGen gnomAD
TCGA novel	22	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1450156572 CA409587197	29	M>L		No	ClinGen TOPMed gnomAD
CA409587226 rs1601070320	30	N>T		No	ClinGen Ensembl
rs1170640605 CA409587246	31	R>C		No	ClinGen TOPMed gnomAD
rs1568902555 CA409587254	31	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA409587260 rs1373835775	32	L>V		No	ClinGen gnomAD
CA9952556 rs201628064	33	I>F		No	ClinGen 1000Genomes ExAC
TCGA novel	34	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9952557 rs756662139	38	V>I		No	ClinGen ExAC TOPMed gnomAD
CA409588023 rs1362823185	46	A>V		No	ClinGen TOPMed
TCGA novel	47	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9952578 rs761316220 COSM1246726	50	R>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1222392973 CA409588100	51	M>L		No	ClinGen TOPMed gnomAD
rs1222392973 CA409588099	51	M>V		No	ClinGen TOPMed gnomAD
TCGA novel	54	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9952579 rs371884399	54	G>R		No	ClinGen ESP ExAC gnomAD
CA409588171 rs965129217	55	I>M		No	ClinGen TOPMed gnomAD
rs1373688249 CA409588187	56	E>D		No	ClinGen TOPMed
TCGA novel	56	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9952580 rs760858651	58	S>N		No	ClinGen ExAC gnomAD
rs17853020 CA317313476	59	V>L		No	ClinGen Ensembl
CA409588439 rs1468841862	69	K>R		No	ClinGen gnomAD
rs776679632 CA317313496	71	R>L		No	ClinGen ExAC gnomAD
CA9952582 rs776679632	71	R>Q		No	ClinGen ExAC gnomAD
COSM1029006 CA409588482 rs1390019835	71	R>W	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs376547637 CA9952583	72	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA409588494 rs376547637	72	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1257860753 CA409588533	73	M>I		No	ClinGen TOPMed
CA409588583 rs1198329137	76	K>Q		No	ClinGen TOPMed
CA317313501 rs866868655	82	A>S		No	ClinGen Ensembl
CA9952585 rs369118795	83	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA317313522 rs1004400506	87	N>K		No	ClinGen Ensembl
rs1385730651 CA409588797	89	L>F		No	ClinGen gnomAD
CA9952587 rs765862348	92	E>K		No	ClinGen ExAC gnomAD
CA317313531 rs961676111	96	T>K		No	ClinGen Ensembl
rs961676111 CA317313539	96	T>R		No	ClinGen Ensembl
CA9952590 rs147843480	98	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	98	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752347409 CA9952612	116	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	116	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9952613 rs755754590	117	E>D		No	ClinGen ExAC TOPMed gnomAD
CA409589332 rs1167456469	120	A>E		No	ClinGen TOPMed gnomAD
rs1167456469 CA409589339	120	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA409589354 rs1431196578	121	A>G		No	ClinGen gnomAD
CA409589352 rs1431196578	121	A>V		No	ClinGen gnomAD
rs745737024 CA9952618	127	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1449989146 CA409589583	134	E>G		No	ClinGen TOPMed
rs773751447 CA409589625	135	E>D		No	ClinGen ExAC gnomAD
TCGA novel	136	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749698400 CA9952624	137	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA409589741 rs1482774457	141	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA409589749 rs1200885053	141	T>I		No	ClinGen gnomAD
rs1463524798 CA409589765	142	E>Q		No	ClinGen gnomAD
TCGA novel	143	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9952626 rs141417758	145	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs759890618 CA409589813	145	R>H		No	ClinGen ExAC gnomAD
CA9952627 rs759890618	145	R>P		No	ClinGen ExAC gnomAD
rs1053521244 CA317313939	146	T>I		No	ClinGen TOPMed
rs1277987709 CA409589844	148	A>V		No	ClinGen gnomAD
rs558506249 CA9952630	153	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9952633 rs757090552	156	E>G		No	ClinGen ExAC
rs753441426 CA9952632	156	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA409589947 rs1367368583	157	E>K		No	ClinGen gnomAD
CA409589967 rs1344943266	158	S>L		No	ClinGen TOPMed
CA9952637 rs781470834	161	G>R		No	ClinGen ExAC gnomAD
rs1233672717 CA409590015	162	D>G		No	ClinGen gnomAD
CA317314030 rs994364268	170	Q>*		No	ClinGen TOPMed
CA409590293 rs1408958886	174	S>R		No	ClinGen gnomAD
CA409590287 rs1350171884	174	S>T		No	ClinGen TOPMed gnomAD
CA409590369 rs1568903783	180	V>L		No	ClinGen Ensembl
CA9952671 rs758517153	181	L>WPVLEST*		No	ClinGen ExAC
CA409590390 rs1568903794	182	D>N		No	ClinGen Ensembl
rs761574215 CA9952673	183	Y>C		No	ClinGen ExAC gnomAD
CA9952672 rs775991928	183	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA9952674 rs769299370	185	N>S		No	ClinGen ExAC TOPMed gnomAD
rs772878499 CA9952675	186	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762677628 CA9952676	186	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs751544681 CA9952678	189	T>I		No	ClinGen ExAC gnomAD
TCGA novel	194	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409591353 rs1415228950	197	K>E		No	ClinGen gnomAD
CA409591357 rs1322653145	197	K>R		No	ClinGen TOPMed
rs1166834958 CA409591386	200	L>F		No	ClinGen TOPMed gnomAD
TCGA novel	200	L>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764323743 CA9952680	202	A>S		No	ClinGen ExAC gnomAD
rs753834492 CA409591430	203	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs145315204 CA317315158	205	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA gnomAD
rs1352268023 CA409591475	207	D>V		No	ClinGen TOPMed
rs1010877167 CA317315175	211	V>I		No	ClinGen TOPMed gnomAD
rs1010877167 CA409591531	211	V>L		No	ClinGen TOPMed gnomAD
CA9952682 rs757323709	212	K>I		No	ClinGen ExAC gnomAD
TCGA novel	212	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1331013629 CA409591570	214	P>T		No	ClinGen gnomAD
CA409591608 rs1441264207	217	T>A		No	ClinGen TOPMed
CA409591613 rs1350233194	217	T>K		No	ClinGen TOPMed
rs1325849550 CA409591619	218	D>N		No	ClinGen TOPMed
rs868747280 CA317315188	219	L>F		No	ClinGen Ensembl
CA409591691 rs1247498582	224	I>L		No	ClinGen gnomAD
CA409591696 rs1294700565	224	I>N		No	ClinGen gnomAD
CA409591714 rs1417339067	225	E>D		No	ClinGen TOPMed
rs982318719 CA317315200	225	E>Q		No	ClinGen Ensembl

No associated diseases with Q9NWU2

No regional properties for Q9NWU2

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NWU2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ubiquitin ligase complex	A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

1 GO annotations of molecular function

Name	Definition
protein homodimerization activity	Binding to an identical protein to form a homodimer.

4 GO annotations of biological process

Name	Definition
positive regulation of canonical Wnt signaling pathway	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q32L52	GID8	Glucose-induced degradation protein 8 homolog	Bos taurus (Bovine)	PR
Q5ZKQ7	GID8	Glucose-induced degradation protein 8 homolog	Gallus gallus (Chicken)	PR
Q9D7M1	Gid8	Glucose-induced degradation protein 8 homolog	Mus musculus (Mouse)	PR
Q6PC55	gid8a	Glucose-induced degradation protein 8-A homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSYAEKPDEI	TKDEWMEKLN	NLHVQRADMN	RLIMNYLVTE	GFKEAAEKFR	MESGIEPSVD
70	80	90	100	110	120
LETLDERIKI	REMILKGQIQ	EAIALINSLH	PELLDTNRYL	YFHLQQQHLI	ELIRQRETEA
130	140	150	160	170	180
ALEFAQTQLA	EQGEESRECL	TEMERTLALL	AFDSPEESPF	GDLLHTMQRQ	KVWSEVNQAV
190	200	210	220
LDYENRESTP	KLAKLLKLLL	WAQNELDQKK	VKYPKMTDLS	KGVIEEPK