Q32L52

PR
Gene name
GID8
Protein name
Glucose-induced degradation protein 8 homolog
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:505570
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-42 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32L52

Entry ID Method Resolution Chain Position Source
AF-Q32L52-F1 Predicted AlphaFoldDB

9 variants for Q32L52

Variant ID(s) Position Change Description Diseaes Association Provenance
rs456176606 22 L>F No EVA
rs434756755 107 Q>P No EVA
rs446154598 111 E>D No EVA
rs464696703 111 E>G No EVA
rs452541999 172 V>G No EVA
rs437163666 174 S>R No EVA
rs476757874 190 P>H No EVA
rs454999048 194 K>N No EVA
rs465976625 229 K>W No EVA

No associated diseases with Q32L52

1 regional properties for Q32L52

Type Name Position InterPro Accession
domain AIG1-type guanine nucleotide-binding (G) domain 25 - 230 IPR006703

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

1 GO annotations of molecular function

Name Definition
protein homodimerization activity Binding to an identical protein to form a homodimer.

4 GO annotations of biological process

Name Definition
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZKQ7 GID8 Glucose-induced degradation protein 8 homolog Gallus gallus (Chicken) PR
Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog Homo sapiens (Human) PR
Q9D7M1 Gid8 Glucose-induced degradation protein 8 homolog Mus musculus (Mouse) PR
Q6PC55 gid8a Glucose-induced degradation protein 8-A homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSYTEKPDEI TKDEWMEKLN NLHVQRADMN RLIMNYLVTE GFKEAAEKFR MESGIEPSVD
70 80 90 100 110 120
LETLDERIKI REMILKGQIQ EAIALINSLH PELLDTNRYL YFHLQQQHLI ELIRQRETEA
130 140 150 160 170 180
ALEFAQTQLA EQGEESRECL TEMERTLALL AFDNPEDSPF GDLLNMMQRQ KVWSEVNQAV
190 200 210 220
LDYENRESTP KLAKLLKLLL WAQNELDQKK VKYPKMTDLS KGVIEEPK