AiPD: Autoinhibited Protein Database

Q9NSE2

Gene name	CISH (G18)
Protein name	Cytokine-inducible SH2-containing protein
Names	CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCS
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1154
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-84 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NSE2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NSE2-F1	Predicted				AlphaFoldDB

227 variants for Q9NSE2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA352960774 rs1417143612	2	V>I		No	ClinGen gnomAD
CA352960768 rs1167039251	3	L>I		No	ClinGen gnomAD
rs1167039251 CA352960767	3	L>V		No	ClinGen gnomAD
TCGA novel	6	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1472655919 CA352960741	6	Q>H		No	ClinGen gnomAD
rs1185678890 CA352960745	6	Q>R		No	ClinGen TOPMed gnomAD
CA352960740 rs1485407475	7	G>R		No	ClinGen gnomAD
rs773008803 CA74646036	8	P>T		No	ClinGen Ensembl
rs371618307 CA2420087	9	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs764969120 CA2420086	9	R>H		No	ClinGen ExAC TOPMed gnomAD
rs764969120 CA352959442	9	R>P		No	ClinGen ExAC TOPMed gnomAD
CA2420085 rs368039402	13	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA74646012 rs1034128799	14	V>M		No	ClinGen TOPMed gnomAD
rs1185329985 CA352959374	15	E>G		No	ClinGen gnomAD
rs561018699 CA352959364	16	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2420083 rs561018699	16	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531354952 CA2420084	16	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM3781840 CA2420081 rs780324307 COSM3781839	20	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2420082 rs375035387	20	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2420079 rs746100479	23	W>*		No	ClinGen ExAC gnomAD
rs758499932 CA74645944	23	W>R		No	ClinGen Ensembl
CA2420078 rs371205890	25	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754311338 CA2420076	26	S>F		No	ClinGen ExAC gnomAD
rs1311242120 CA352959265	26	S>P		No	ClinGen TOPMed
rs1410557075 CA352959228	29	L>P		No	ClinGen TOPMed
rs752881452 CA74645920	33	V>L		No	ClinGen Ensembl
rs1356741514 CA352957778	34	M>V		No	ClinGen TOPMed gnomAD
CA352957752 rs1168693701	35	Q>H		No	ClinGen gnomAD
rs756680989 CA2420073	36	P>A		No	ClinGen ExAC
rs1428477665 CA352957725	37	L>F		No	ClinGen gnomAD
CA2420072 rs751038035	39	A>T		No	ClinGen ExAC TOPMed gnomAD
CA74645903 rs923598427	40	G>E		No	ClinGen TOPMed gnomAD
CA74645893 rs191032931	41	A>D		No	ClinGen 1000Genomes TOPMed gnomAD
rs762538997 CA2420070	44	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	45	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201896056 CA2420069	45	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201896056 CA2420068	45	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2420067 rs761502849	46	V>E		No	ClinGen ExAC gnomAD
rs768686842 CA2420065	48	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA352957598 rs1353703124	48	E>G		No	ClinGen gnomAD
rs776559824 CA2420066	48	E>K		No	ClinGen ExAC gnomAD
rs1453261848 CA352957589	49	G>C		No	ClinGen TOPMed
rs765416701 CA2420064	50	T>A		No	ClinGen ExAC gnomAD
rs796627241 CA74645850	51	P>Q		No	ClinGen Ensembl
rs1377464891 CA352957567	51	P>S		No	ClinGen gnomAD
CA2420062 rs562587305	54	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA2420063 rs562587305	54	T>R		No	ClinGen 1000Genomes ExAC gnomAD
CA352957530 rs1296833352	54	T>S		No	ClinGen gnomAD
CA352957514 rs1199440919	55	E>D		No	ClinGen TOPMed
CA352957517 rs1373965039	55	E>G		No	ClinGen gnomAD
TCGA novel	55	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746037457 CA2420061	56	S>G		No	ClinGen ExAC gnomAD
rs1474507293 CA352957484	57	E>D		No	ClinGen TOPMed gnomAD
CA352957455 rs1415044413	59	K>N		No	ClinGen gnomAD
rs916821029 CA74645827	60	V>M		No	ClinGen Ensembl
rs749611185 CA2420058	66	D>V		No	ClinGen ExAC gnomAD
CA74645797 rs761635256	68	L>P		No	ClinGen gnomAD
rs991020460 CA74645794	70	I>V		No	ClinGen gnomAD
CA352957353 rs1292779152	71	A>V		No	ClinGen gnomAD
CA352957337 COSM1046540 COSM1046539 rs1233924693	74	F>L	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	75	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1392329502 CA352957316	77	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs148162012 CA352957305	78	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148162012 RCV000896832 CA2420054	78	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2420055 rs141046429	78	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs929428092 CA74645417	83	Y>C		No	ClinGen Ensembl
rs368792354 CA74645401	85	G>D		No	ClinGen ESP TOPMed gnomAD
CA2420030 rs755987753	86	S>A		No	ClinGen ExAC gnomAD
rs1188765915 CA352957081	87	I>V		No	ClinGen TOPMed
rs767350636 CA2420028	88	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	88	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259753387 CA352957021	89	A>G		No	ClinGen TOPMed gnomAD
CA352957011 rs1204593424	90	S>G		No	ClinGen gnomAD
rs766498255 CA2420025	91	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1232361040 CA352956942	92	A>V		No	ClinGen gnomAD
rs373552550 CA2420024	93	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs200588661 CA2420023	93	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA352956911 rs770083611	94	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA2420022 rs770083611	94	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA352956866 rs1325156710	96	L>P		No	ClinGen gnomAD
CA352956873 rs1396191507	96	L>V		No	ClinGen TOPMed
CA2420021 rs762164564	97	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA2420020 rs376687415	103	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs144012341 CA2420019	103	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs747577229 CA2420018	106	V>G		No	ClinGen ExAC gnomAD
CA2420017 rs145632110	107	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs377401159 CA352956588	107	R>H		No	ClinGen TOPMed gnomAD
rs377401159 CA74645311	107	R>P		No	ClinGen TOPMed gnomAD
rs1371222048 CA352956564	108	D>G		No	ClinGen gnomAD
CA2420015 rs748893210	110	T>M		No	ClinGen ExAC TOPMed gnomAD
CA352956481 rs1575984299	111	H>P		No	ClinGen Ensembl
CA2420012 rs752507448	115	L>Q		No	ClinGen ExAC gnomAD
rs781089685 CA2420011	117	T>M		No	ClinGen ExAC TOPMed gnomAD
rs369545796 CA2420008	122	T>N		No	ClinGen ESP ExAC gnomAD
CA2420006 rs750557678	123	T>A		No	ClinGen ExAC gnomAD
rs140032833 CA2420005	124	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2420004 rs762076085	124	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	128	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	128	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761020637 CA2420001	130	R>C		No	ClinGen ExAC TOPMed gnomAD
CA74645192 rs201825038	130	R>H		No	ClinGen TOPMed
rs201825038 CA74645191	130	R>L		No	ClinGen TOPMed
rs761020637 CA352956227	130	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1394057671 CA352956223	131	I>V		No	ClinGen gnomAD
rs748801053 CA2419998	133	Y>H		No	ClinGen ExAC gnomAD
CA74645182 rs929825606	134	A>T		No	ClinGen TOPMed
CA74645174 rs866100406	134	A>V		No	ClinGen TOPMed
CA2419995 rs143405439	135	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA352956197 rs143405439	135	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	137	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1475015141 CA352956182	137	S>N		No	ClinGen gnomAD
rs747825441 CA2419993	138	F>C		No	ClinGen ExAC gnomAD
CA2419992 rs780805211	139	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1436502044 CA352956168	139	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA352956162 rs1196900431	140	L>P		No	ClinGen TOPMed gnomAD
CA352956163 rs1196900431	140	L>Q		No	ClinGen TOPMed gnomAD
CA2419990 rs145827559	143	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2419988 rs368519911	145	L>M		No	ClinGen ESP ExAC gnomAD
CA2419987 rs750482467	148	P>T		No	ClinGen ExAC gnomAD
rs375441453 CA2419985	149	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs375441453 CA2419986	149	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs750398759 CA2419984	149	R>H		No	ClinGen ExAC TOPMed gnomAD
rs750398759 CA2419983	149	R>L		No	ClinGen ExAC TOPMed gnomAD
rs372377941 CA2419982	150	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs775787307 CA2419981	154	P>L		No	ClinGen ExAC TOPMed gnomAD
rs760168237 CA2419979	155	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1173367715 CA352956068	156	V>M		No	ClinGen TOPMed
CA352956034 rs1247980200	161	Q>*		No	ClinGen gnomAD
CA74644963 rs419160 CA2419978	162	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	162	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1431193711 CA352955993	167	C>Y		No	ClinGen TOPMed
rs769459339 CA2419977	168	T>A		No	ClinGen ExAC gnomAD
CA352955964 rs1183878287	171	T>I		No	ClinGen gnomAD
CA352955968 rs1575983964	171	T>P		No	ClinGen Ensembl
CA2419976 rs151134438	172	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2419975 rs151134438	172	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374472627 CA352955963	172	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs374472627 CA2419973	172	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs779764644 CA2419972	173	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs920731874 CA74644934	174	D>H		No	ClinGen TOPMed
CA352955954 rs920731874	174	D>N		No	ClinGen TOPMed
rs1221665399 CA352955946	175	S>G		No	ClinGen TOPMed gnomAD
TCGA novel	175	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201615384 CA2419969	177	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201615384 CA352955929 COSM361244 COSM361243	177	D>Y	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs419202 CA74644913	178	P>R		No	ClinGen Ensembl
COSM213645 CA2419968 rs757344255	178	P>S	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs753924515 CA352955892	179	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753924515 CA2419967	179	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2419966 rs368081240	180	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA352955865 rs1575983857	181	T>P		No	ClinGen Ensembl
CA2419963 rs768014875	182	P>L		No	ClinGen ExAC TOPMed gnomAD
CA2419964 rs768014875	182	P>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	183	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs419346 CA74644850	185	P>H		No	ClinGen Ensembl
CA352955752 rs1186697471	187	P>S		No	ClinGen TOPMed
rs1378795531 CA352955708	189	E>G		No	ClinGen gnomAD
rs764779412 CA352955662	191	A>E		No	ClinGen ExAC TOPMed gnomAD
rs764779412 CA2419960	191	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA74644825 rs371715	192	P>H		No	ClinGen gnomAD
rs371715 CA352955643	192	P>L		No	ClinGen gnomAD
rs776069534 CA2419958	192	P>S		No	ClinGen ExAC gnomAD
CA352955628 rs1399211736	193	S>I		No	ClinGen gnomAD
rs1575983788 CA352955608	194	D>A		No	ClinGen Ensembl
rs768335850 CA2419957	195	P>L		No	ClinGen ExAC gnomAD
rs746666602 CA2419956	196	A>S		No	ClinGen ExAC gnomAD
rs141201807 CA2419953	197	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2419954 rs371586881	197	L>V		No	ClinGen ExAC gnomAD
rs1575983764 CA352955534	199	A>P		No	ClinGen Ensembl
rs1489052279 CA352955506	200	P>R		No	ClinGen gnomAD
rs749359011 CA2419950	201	P>L		No	ClinGen ExAC gnomAD
rs1460802884 CA352955459	203	A>P		No	ClinGen TOPMed
rs756310030 CA2419948	203	A>V		No	ClinGen ExAC gnomAD
CA2419946 rs767926742	204	T>S		No	ClinGen ExAC gnomAD
CA74644718 rs966907414	206	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA74644727 rs755402867	206	V>I		No	ClinGen ExAC gnomAD
CA2419945 rs755402867	206	V>L		No	ClinGen ExAC gnomAD
CA352955377 rs1233479737	207	H>Q		No	ClinGen TOPMed gnomAD
CA352955311 rs1336621874	211	V>L		No	ClinGen gnomAD
rs898325233 CA74644703	212	Q>*		No	ClinGen TOPMed gnomAD
rs1361491141 CA352955290	212	Q>R		No	ClinGen TOPMed
CA2419941 rs753342365	216	R>C		No	ClinGen ExAC TOPMed gnomAD
rs145267067 CA2419940	216	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2419942 rs753342365	216	R>S		No	ClinGen ExAC TOPMed gnomAD
rs760312690 CA352955163	219	S>G		No	ClinGen ExAC TOPMed gnomAD
rs760312690 CA2419939	219	S>R		No	ClinGen ExAC TOPMed gnomAD
CA352955142 rs1159165798	220	A>T		No	ClinGen TOPMed gnomAD
CA2419937 rs771770192 COSM3767478 COSM3767479	221	R>C	Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs139699451 CA2419935	221	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2419936 rs139699451	221	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA352955109 rs1185255986	222	S>G		No	ClinGen gnomAD
rs1575983609 CA352955055	224	Q>H		No	ClinGen Ensembl
CA2419932 rs777867992	225	H>N		No	ClinGen ExAC gnomAD
CA352955042 rs769768271	225	H>P		No	ClinGen ExAC gnomAD
CA2419931 rs769768271	225	H>R		No	ClinGen ExAC gnomAD
rs199577641 CA74644594	228	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA352954910 rs1209105769	232	N>S		No	ClinGen gnomAD
CA352954912 rs1209105769	232	N>T		No	ClinGen gnomAD
CA74644571 rs371376746	233	R>C		No	ClinGen ESP TOPMed gnomAD
CA2419929 rs544358335	233	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	236	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201634298 CA2419927	237	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA352954797 rs1575983534	238	V>G		No	ClinGen Ensembl
CA352954808 rs1373811515	238	V>M		No	ClinGen TOPMed gnomAD
rs1575983532 CA352954773	240	C>R		No	ClinGen Ensembl
rs780590017 CA2419925	240	C>W		No	ClinGen ExAC gnomAD
CA352954769 rs1312474325	240	C>Y		No	ClinGen gnomAD
CA352954740 rs1190049671	242	P>S		No	ClinGen Ensembl
CA352954703 rs1169026456	244	P>L		No	ClinGen gnomAD
CA2419924 rs376743036	245	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs138916184 CA2419923	245	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA352954695 rs376743036	245	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs763606547 CA2419922	246	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2419920 rs752271815	247	M>V		No	ClinGen ExAC gnomAD
rs943434425 CA74644504	248	A>T		No	ClinGen TOPMed gnomAD
CA2419918 rs189244040	249	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2419917 rs774081733	250	Y>H		No	ClinGen ExAC gnomAD
rs1575983419 CA352954608	250	Y>S		No	ClinGen Ensembl
rs770662400 CA2419916	252	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762880342 CA2419915	252	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2419914 rs769823296	253	Q>L		No	ClinGen ExAC gnomAD
rs769823296 CA2419913	253	Q>R		No	ClinGen ExAC gnomAD
CA2419910 rs768974999	256	F>C		No	ClinGen ExAC TOPMed gnomAD
CA352954507 rs1396813925	256	F>L		No	ClinGen gnomAD
rs747268233 CA352954483	257	Q>L		No	ClinGen ExAC gnomAD
rs747268233 CA2419909	257	Q>P		No	ClinGen ExAC gnomAD
rs747268233 CA352954480	257	Q>R		No	ClinGen ExAC gnomAD

No associated diseases with Q9NSE2

3 regional properties for Q9NSE2

Type	Name	Position	InterPro Accession
domain	SH2 domain	80 - 188	IPR000980
domain	SOCS box domain	209 - 257	IPR001496
domain	CIS, SH2 domain	77 - 164	IPR035887

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phosphatidylinositol 3-kinase complex	A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
1-phosphatidylinositol-3-kinase regulator activity	Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.

6 GO annotations of biological process

Name	Definition
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of signal transduction	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
phosphatidylinositol phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
protein kinase C-activating G protein-coupled receptor signaling pathway	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2HJ53	CISH	Cytokine-inducible SH2-containing protein	Bos taurus (Bovine)	PR
Q9PW70	CISH	Cytokine-inducible SH2-containing protein	Gallus gallus (Chicken)	PR
Q62225	Cish	Cytokine-inducible SH2-containing protein	Mus musculus (Mouse)	PR
O70512	Cish	Cytokine-inducible SH2-containing protein	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MVLCVQGPRP	LLAVERTGQR	PLWAPSLELP	KPVMQPLPAG	AFLEEVAEGT	PAQTESEPKV
70	80	90	100	110	120
LDPEEDLLCI	AKTFSYLRES	GWYWGSITAS	EARQHLQKMP	EGTFLVRDST	HPSYLFTLSV
130	140	150	160	170	180
KTTRGPTNVR	IEYADSSFRL	DSNCLSRPRI	LAFPDVVSLV	QHYVASCTAD	TRSDSPDPAP
190	200	210	220	230	240
TPALPMPKED	APSDPALPAP	PPATAVHLKL	VQPFVRRSSA	RSLQHLCRLV	INRLVADVDC
250
LPLPRRMADY	LRQYPFQL