Q2HJ53

PR
Gene name
CISH
Protein name
Cytokine-inducible SH2-containing protein
Names
CIS
Species
Bos taurus (Bovine)
KEGG Pathway
bta:616753
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HJ53

Entry ID Method Resolution Chain Position Source
AF-Q2HJ53-F1 Predicted AlphaFoldDB

134 variants for Q2HJ53

Variant ID(s) Position Change Description Diseaes Association Provenance
rs442952307 9 C>W No EVA
rs459927367 10 P>L No EVA
rs444938011 11 L>F No EVA
rs481772448 15 E>* No EVA
rs467641417 15 E>D No EVA
rs450530887 15 E>V No EVA
rs436303890 16 Q>K No EVA
rs453065478 17 I>M No EVA
rs209463645 19 Q>R No EVA
rs471718203 20 R>P No EVA
rs451661122 20 R>W No EVA
rs443555861 22 L>P No EVA
rs474290097 23 W>L No EVA
rs443121024 24 A>P No EVA
rs438994564 25 Q>H No EVA
rs473544109 25 Q>K No EVA
rs481937156 29 L>R No EVA
rs460977175 30 P>A No EVA
rs481303759 31 Q>R No EVA
rs466893813 37 L>* No EVA
rs465272521 42 F>S No EVA
rs437288635 43 L>R No EVA
rs134059616 44 E>D No EVA
rs474047072 47 V>I No EVA
rs436393362 50 S>T No EVA
rs453496275 51 P>T No EVA
rs438954311 59 K>Q No EVA
rs459172189 60 V>A No EVA
rs475481953 62 D>V No EVA
rs444185948 65 E>D No EVA
rs460940473 68 L>V No EVA
rs480968885 69 C>F No EVA
rs477363706 71 A>D No EVA
rs460368632 71 A>T No EVA
rs445772816 72 K>R No EVA
rs476059489 84 W>* No EVA
rs435156820 88 T>R No EVA
rs455581414 90 S>R No EVA
rs472496798 97 Q>E No EVA
rs440964547 103 T>P No EVA
rs457894461 104 F>L No EVA
rs471070488 106 V>G No EVA
rs462952490 110 T>N No EVA
rs439774285 110 T>P No EVA
rs482972058 111 H>L No EVA
rs482972058 111 H>P No EVA
rs462420454 114 Y>* No EVA
rs448398107 114 Y>S No EVA
rs479378708 119 S>A No EVA
rs447838852 120 V>I No EVA
rs464632852 122 T>P No EVA
rs449645465 123 T>N No EVA
rs432842752 123 T>P No EVA
rs469717043 125 G>W No EVA
rs435119899 126 P>T No EVA
rs455269041 128 N>Y No EVA
rs434714327 129 V>G No EVA
rs471642087 131 I>V No EVA
rs443451247 133 Y>D No EVA
rs456589762 140 L>P No EVA
rs133317693 143 N>T No EVA
rs462152895 150 I>T No EVA
rs479347601 154 P>Q No EVA
rs458277963 157 V>G No EVA
rs441538427 157 V>L No EVA
rs386056528 164 V>M No EVA
rs478169427 170 D>N No EVA
rs450211300 171 T>P No EVA
rs480403054 173 S>R No EVA
rs434677153 176 P>L No EVA
rs465276947 177 D>A No EVA
rs451450842 177 D>N No EVA
rs457151924 179 A>G No EVA
rs436958637 179 A>P No EVA
rs476684670 180 T>P No EVA
rs476684670 180 T>S No EVA
rs442129543 181 T>P No EVA
rs472531854 183 A>V No EVA
rs441206317 184 L>P No EVA
rs441206317 184 L>R No EVA
rs478333135 185 P>T No EVA
rs443771714 186 T>P No EVA
rs443771714 186 T>S No EVA
rs876395553 187 P>L No EVA
rs463826243 190 D>E No EVA
rs480341199 191 A>P No EVA
rs479415539 193 G>V No EVA
rs437126653 194 D>A No EVA
rs465238481 194 D>H No EVA
rs450708282 195 P>Q No EVA
rs455713268 196 A>D No EVA
rs436193121 196 A>P No EVA
rs455713268 196 A>V No EVA
rs434750870 198 P>T No EVA
rs451624774 200 T>P No EVA
rs443939670 203 H>L No EVA
rs463787697 205 K>N No EVA
rs443023505 208 Q>H No EVA
rs459347060 209 P>A No EVA
rs444830432 213 R>G No EVA
rs458567863 213 R>S No EVA
rs482111158 215 S>C No EVA
rs482111158 215 S>R No EVA
rs450771685 216 T>P No EVA
rs467699749 217 R>G No EVA
rs436150986 218 S>R No EVA
rs434813615 220 Q>L No EVA
rs451604451 221 H>P No EVA
rs451604451 221 H>R No EVA
rs474503715 223 C>G No EVA
rs443020719 223 C>S No EVA
rs443020719 223 C>Y No EVA
rs459917759 224 R>H No EVA
rs473088505 225 L>M No EVA
rs438472947 226 V>A No EVA
rs458629045 227 I>F No EVA
rs481858840 227 I>T No EVA
rs137311656 228 N>T No EVA
rs461233647 229 R>L No EVA
rs481334028 231 V>G No EVA
rs466745005 233 D>A No EVA
rs466745005 233 D>G No EVA
rs479718954 234 V>L No EVA
rs465286963 236 C>S No EVA
rs876507632 238 P>R No EVA
rs437190722 239 L>P No EVA
rs468065952 241 R>G No EVA
rs436651478 241 R>Q No EVA
rs439016330 243 M>I No EVA
rs473640919 243 M>K No EVA
rs452261589 248 R>G No EVA
rs475477913 249 Q>K No EVA
rs460916629 255 L>C No EVA
rs460916629 255 L>W No EVA

No associated diseases with Q2HJ53

3 regional properties for Q2HJ53

Type Name Position InterPro Accession
domain SH2 domain 80 - 188 IPR000980
domain SOCS box domain 205 - 253 IPR001496
domain CIS, SH2 domain 77 - 164 IPR035887

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-kinase regulator activity Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.

5 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9PW70 CISH Cytokine-inducible SH2-containing protein Gallus gallus (Chicken) PR
Q9NSE2 CISH Cytokine-inducible SH2-containing protein Homo sapiens (Human) PR
Q62225 Cish Cytokine-inducible SH2-containing protein Mus musculus (Mouse) PR
O70512 Cish Cytokine-inducible SH2-containing protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVLCVQGLCP LLAVEQIGQR PLWAQSLELP QQVMQPLSAG AFLEEAVEES PAQPEREPKV
70 80 90 100 110 120
VDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV
130 140 150 160 170 180
KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCAAD TRSDSPDLAT
190 200 210 220 230 240
TPALPTPKED APGDPALPAT AVHLKLVQPF VRRSSTRSLQ HLCRLVINRL VVDVDCLPLP
250
RRMADYLRQY PFQL