AiPD: Autoinhibited Protein Database

Q9NQZ7

Gene name	ENTPD7 (LALP1)
Protein name	Ectonucleoside triphosphate diphosphohydrolase 7
Names	NTPDase 7, Lysosomal apyrase-like protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57089
EC number	3.6.1.15: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-162 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

22-162 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NQZ7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NQZ7-F1	Predicted				AlphaFoldDB

473 variants for Q9NQZ7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs550879549 CA5641465	2	A>T		No	ClinGen ExAC gnomAD
CA5641466 rs768540983	3	R>G		No	ClinGen ExAC gnomAD
rs1195847902 CA378084344	3	R>K		No	ClinGen TOPMed gnomAD
CA5641496 rs772305050	5	S>G		No	ClinGen ExAC TOPMed gnomAD
CA5641495 rs772305050	5	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	6	F>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5641497 rs201964022	8	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs368414215 CA212790896	10	C>R		No	ClinGen Ensembl
CA5641500 rs759820848	14	W>L		No	ClinGen ExAC gnomAD
rs1325261360 CA378086988	16	F>L		No	ClinGen gnomAD
rs1204367405 CA378087004	17	T>P		No	ClinGen TOPMed
rs765731958 CA5641501	17	T>S		No	ClinGen ExAC gnomAD
CA212790929 rs936575752	18	V>A		No	ClinGen gnomAD
CA5641503 rs763499616	19	P>R		No	ClinGen ExAC gnomAD
rs1484743292 CA378087035	20	T>A		No	ClinGen TOPMed
rs376539042 CA5641504	20	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1314828676 CA378087075	21	V>A		No	ClinGen gnomAD
rs755748626 CA5641506	22	S>N		No	ClinGen ExAC TOPMed gnomAD
CA5641508 rs753602972	26	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs143637078 CA5641509	26	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5641510 rs143637078	26	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM913771 rs748017544 CA5641511	28	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1024519460 CA212790964	28	R>W		No	ClinGen TOPMed
rs35229854 CA5641513	29	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1416634918 CA378087212	30	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5641515 rs147747082	32	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378087268 rs147747082	32	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA212791006 rs930137089	35	F>Y		No	ClinGen Ensembl
CA5641519 rs770032562	44	M>T		No	ClinGen ExAC TOPMed gnomAD
CA5641518 rs150267092	44	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378087591 rs775962695	47	I>L		No	ClinGen ExAC TOPMed gnomAD
CA378087595 COSM1716982 rs1373596700	47	I>T	NS [Cosmic]	No	ClinGen cosmic curated TOPMed
CA5641520 rs775962695	47	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM913772 CA378087653 rs1319466916	50	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA378087685 rs1214083170	51	H>R		No	ClinGen TOPMed
rs139286607 CA5641524	51	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1442605450 CA378087716	52	W>C		No	ClinGen gnomAD
rs1211296721 CA378087731	53	S>N		No	ClinGen gnomAD
CA5641526 rs766015292	57	P>R		No	ClinGen ExAC
rs370286436 CA5641527	58	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA5641528 rs370286436	58	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5641529 rs61729539	58	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758400449 CA5641531	61	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs777855779 CA5641532	61	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA5641534 rs756362966	63	E>K	Variant assessed as Somatic; 4.672e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1177981868 CA378087953	64	R>K		No	ClinGen gnomAD
CA378091080 rs1286958548	64	R>S		No	ClinGen gnomAD
CA5641549 rs764070287	65	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA5641550 rs751516229	68	R>*		No	ClinGen ExAC gnomAD
rs751516229 CA378091140	68	R>G		No	ClinGen ExAC gnomAD
rs757258139 CA5641551	68	R>Q		No	ClinGen ExAC gnomAD
CA378091146 rs1362406037	69	V>I		No	ClinGen TOPMed gnomAD
rs1398826044 CA378091191	74	A>S		No	ClinGen TOPMed gnomAD
rs1398826044 CA378091190	74	A>T		No	ClinGen TOPMed gnomAD
CA5641554 rs756231191	77	T>P		No	ClinGen ExAC gnomAD
CA378091232 rs1300869156	77	T>S		No	ClinGen gnomAD
CA378091236 rs1234061955	78	E>K		No	ClinGen gnomAD
CA378091304 rs1442187370	82	L>V		No	ClinGen TOPMed
rs780260445 CA5641555	85	G>A		No	ClinGen ExAC gnomAD
CA212801900 rs372561364	87	V>A		No	ClinGen ESP gnomAD
TCGA novel	88	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1203832221	88	V>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1223831549 CA378091429	90	C>R		No	ClinGen gnomAD
rs749614688 CA5641556	90	C>Y		No	ClinGen ExAC gnomAD
rs1590043456 CA378091455	93	S>R		No	ClinGen Ensembl
CA378091452 rs1179042193	93	S>T		No	ClinGen gnomAD
rs775993892 CA5641561	96	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs199591970 CA5641560	96	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1590043504 TCGA novel CA378091472	97	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs200759032 CA212801942	99	V>L		No	ClinGen gnomAD
CA5641564 CA378091557 COSM74520 rs764753437	108	N>K	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC TOPMed gnomAD NCI-TCGA
CA5641565 rs775301582	110	H>Q		No	ClinGen ExAC gnomAD
CA212801958 rs1004447088	111	D>N		No	ClinGen Ensembl
rs1480297817 CA378091588	113	L>P		No	ClinGen TOPMed
rs763947377 CA5641567	115	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5641568 rs751466685	116	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5641570 rs767501634	121	R>C		No	ClinGen ExAC TOPMed gnomAD
rs767501634 CA378091644	121	R>G		No	ClinGen ExAC TOPMed gnomAD
rs368620286 CA5641571	121	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs368620286 CA5641572	121	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs780203334 CA5641573	125	P>S		No	ClinGen ExAC gnomAD
rs1307142921 CA378091698	126	V>M		No	ClinGen TOPMed
CA378091730 rs1240250312	128	K>E		No	ClinGen gnomAD
rs1305138457 CA378091792	132	P>T		No	ClinGen TOPMed
rs562711164 CA212802013	133	G>*		No	ClinGen Ensembl
rs761468163 CA5641605	133	G>A		No	ClinGen ExAC gnomAD
rs1564630192 CA378092053	136	A>V		No	ClinGen Ensembl
CA378092132 rs1324923427	140	T>A		No	ClinGen gnomAD
CA212802270 rs1014921447	141	P>T		No	ClinGen TOPMed
rs772921610 CA5641607	143	H>R		No	ClinGen ExAC gnomAD
CA5641608 rs760658234	145	S>G		No	ClinGen ExAC gnomAD
rs61742499 CA212802300	145	S>R		No	ClinGen Ensembl
rs1440297930 CA378092269	146	D>N		No	ClinGen TOPMed
rs759251122 CA5641609	146	D>V		No	ClinGen ExAC TOPMed gnomAD
rs759619517 CA5641611	147	Y>*		No	ClinGen ExAC gnomAD
CA5641610 rs776636403	147	Y>H		No	ClinGen ExAC gnomAD
CA5641612 rs765391236	148	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1187782502 CA378092352	149	R>C		No	ClinGen TOPMed gnomAD
rs765221261 CA5641613 COSM913773	149	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA378092396 rs1426420430	150	P>L		No	ClinGen TOPMed
rs1268985332 CA378092503	153	S>R		No	ClinGen TOPMed
rs1028414398 CA212802332	155	A>T		No	ClinGen Ensembl
CA378092605 rs1317011908	156	A>V		No	ClinGen TOPMed gnomAD
rs1199205503 CA378092650	158	H>P		No	ClinGen gnomAD
CA378092669 rs1437015705	159	V>M		No	ClinGen gnomAD
rs757780814 CA5641617	160	P>L		No	ClinGen ExAC gnomAD
CA5641616 rs751925424	160	P>S		No	ClinGen ExAC gnomAD
rs748766209 CA5641619	161	V>E		No	ClinGen ExAC gnomAD
CA378092857 rs1201145553	164	H>Q		No	ClinGen TOPMed
CA5641620 rs754559411	165	K>R		No	ClinGen ExAC gnomAD
rs1340659907 CA378092895	166	E>D		No	ClinGen TOPMed
rs778338201 CA5641621	167	T>N		No	ClinGen ExAC gnomAD
rs1251154639 CA378092917	169	L>F		No	ClinGen TOPMed
CA5641622 rs747805629	170	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1590043827 CA378092963	176	G>S		No	ClinGen Ensembl
CA5641624 rs773050855	177	M>L		No	ClinGen ExAC TOPMed gnomAD
CA378092967 rs773050855	177	M>V		No	ClinGen ExAC TOPMed gnomAD
CA378092977 rs1233767551	178	R>K		No	ClinGen TOPMed
CA5641625 rs139519525	179	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA212802427 rs267602335	181	P>S		No	ClinGen Ensembl
rs1481191608 CA378094399	185	Q>*		No	ClinGen gnomAD
CA378094456 rs370666357	188	I>L		No	ClinGen ESP gnomAD
CA212805600 rs370666357	188	I>V		No	ClinGen ESP gnomAD
rs1418951146 CA378094491	190	A>T		No	ClinGen gnomAD
CA5641648 rs770686860	191	D>N	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378094521 rs1420026688	192	L>I		No	ClinGen gnomAD
rs928190238 CA212805639	192	L>Q		No	ClinGen TOPMed
rs776446713 CA5641649	195	D>G		No	ClinGen ExAC gnomAD
rs1164546473 CA378094579	196	L>I		No	ClinGen TOPMed gnomAD
CA378094599 rs1355307487	197	P>L		No	ClinGen gnomAD
rs991002328 CA212805648	198	L>M		No	ClinGen TOPMed
CA5641652 rs775580618	199	E>D		No	ClinGen ExAC gnomAD
rs1372544199 CA378094621	199	E>K		No	ClinGen gnomAD
CA378094641 rs201287793	200	F>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201287793 CA5641653	200	F>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1332107844 CA378094650	201	D>N		No	ClinGen gnomAD
CA212805695 rs200454165	203	L>F		No	ClinGen 1000Genomes gnomAD
CA378094682 rs200454165	203	L>V		No	ClinGen 1000Genomes gnomAD
TCGA novel	206	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1409638737 CA378094730	206	Q>P		No	ClinGen TOPMed
CA378094744 rs1207090942	207	S>Y		No	ClinGen gnomAD
rs1564631619 CA378094774	209	A>V		No	ClinGen Ensembl
rs1231473196 CA378094778	210	E>Q		No	ClinGen gnomAD
CA5641656 rs756734808	211	V>L		No	ClinGen ExAC gnomAD
CA5641655 rs756734808	211	V>M		No	ClinGen ExAC gnomAD
rs1189350097 CA378094835	214	G>E		No	ClinGen gnomAD
rs767963453 CA5641657	217	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1310163276 CA378095057	218	G>V		No	ClinGen TOPMed gnomAD
CA5641670 rs749339786	219	V>I		No	ClinGen ExAC TOPMed gnomAD
rs762122699 CA5641673	221	A>S		No	ClinGen ExAC gnomAD
rs772483140 CA5641674	221	A>V		No	ClinGen ExAC gnomAD
rs1433961243 CA378095108	222	W>L		No	ClinGen gnomAD
rs773655463 CA5641675	222	W>R		No	ClinGen ExAC TOPMed gnomAD
rs760954750 CA5641676	223	I>T		No	ClinGen ExAC gnomAD
rs766872009 CA5641677	224	G>A		No	ClinGen ExAC gnomAD
rs562789603 CA5641679	226	N>K		No	ClinGen ExAC TOPMed gnomAD
CA5641678 rs754327990	226	N>S		No	ClinGen ExAC TOPMed gnomAD
CA5641680 rs763586639	231	R>T		No	ClinGen ExAC TOPMed gnomAD
rs751125972 CA5641681	232	F>L		No	ClinGen ExAC gnomAD
CA5641682 rs756842180	233	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1421340165 CA378096320	234	H>Y		No	ClinGen TOPMed
rs1285562150 CA378096355	235	E>G		No	ClinGen gnomAD
rs1158052179 CA378096377	236	D>V		No	ClinGen TOPMed
CA212806998 rs756817450	237	E>K		No	ClinGen Ensembl
CA378096422 rs1267520706	238	S>L		No	ClinGen TOPMed gnomAD
rs1590049356 CA378096418	238	S>T		No	ClinGen Ensembl
CA378096433 rs1167033345	240	A>D		No	ClinGen TOPMed
rs555177484 CA5641698	240	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1182213173 CA378096489	248	A>G		No	ClinGen gnomAD
TCGA novel	248	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378096494 rs1196342307	249	G>E		No	ClinGen gnomAD
CA5641703 rs767106170	250	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5641702 rs761342650	250	R>W		No	ClinGen ExAC gnomAD
rs1590049398 CA378096500	251	R>G		No	ClinGen Ensembl
rs1418033504	252	R>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs755830723 CA212808266	253	T>I		No	ClinGen ExAC TOPMed gnomAD
CA5641705 rs755830723	253	T>K		No	ClinGen ExAC TOPMed gnomAD
CA378096523 rs1590049418	254	V>G		No	ClinGen Ensembl
rs753724661 CA5641707	256	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1329904442 CA378096548	258	D>E		No	ClinGen gnomAD
CA378096545 rs1483302579	258	D>G		No	ClinGen TOPMed
CA5641708 rs754816498	259	M>R		No	ClinGen ExAC gnomAD
rs748202130 CA5641710	261	G>R		No	ClinGen ExAC gnomAD
CA378096572 rs758575613	262	A>G		No	ClinGen ExAC gnomAD
CA5641711 rs758575613	262	A>V		No	ClinGen ExAC gnomAD
rs778053103 CA5641712	263	S>F		No	ClinGen ExAC gnomAD
CA5641713 rs747188963	264	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1435866095 CA378096603	267	A>V		No	ClinGen gnomAD
CA212808303 rs1041614029	268	Y>C		No	ClinGen TOPMed
rs369321164 CA5641716	269	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA378096659 rs1328874098	271	P>L		No	ClinGen TOPMed
rs770245006 CA5641717	271	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5641719 rs763499551	272	T>A		No	ClinGen ExAC gnomAD
CA378096706 rs1462127474	274	T>N		No	ClinGen gnomAD
CA5641721 VAR_030287 rs11190245	276	V>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA378096736 rs1331939448	276	V>I		No	ClinGen gnomAD
rs771682518 CA212808310	277	L>F		No	ClinGen Ensembl
rs1408556136 CA378096781	279	A>T		No	ClinGen gnomAD
rs772845848 CA5641722	279	A>V		No	ClinGen ExAC gnomAD
TCGA novel	283	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760237478 CA5641743	284	A>G		No	ClinGen ExAC gnomAD
rs772540029 CA5641742	284	A>S		No	ClinGen ExAC gnomAD
CA5641744 rs770452082	286	K>Q		No	ClinGen ExAC gnomAD
rs1349967872 CA378097294	287	I>T		No	ClinGen gnomAD
rs776370975 CA5641746	289	L>R		No	ClinGen ExAC TOPMed gnomAD
CA378097345 rs1205442940	291	E>D		No	ClinGen TOPMed
CA5641747 rs759313528	292	F>I		No	ClinGen ExAC TOPMed gnomAD
CA5641749 rs752609712	297	D>G		No	ClinGen ExAC gnomAD
rs1018738513 CA212813229	299	Q>*		No	ClinGen Ensembl
rs369563076 CA5641750	300	H>L		No	ClinGen ESP ExAC gnomAD
CA378097473 rs764094290	301	T>I		No	ClinGen ExAC gnomAD
CA5641751 rs764094290	301	T>N		No	ClinGen ExAC gnomAD
rs1352393566 CA378097534	304	V>G		No	ClinGen TOPMed
rs987855333 CA212813237	304	V>M		No	ClinGen gnomAD
TCGA novel	306	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174634561 CA378097581	306	R>S		No	ClinGen gnomAD
rs757378688 CA5641753	307	V>I		No	ClinGen ExAC gnomAD
rs1021265840 CA212813260	311	T>I		No	ClinGen TOPMed
CA378097681 rs1021265840	311	T>N		No	ClinGen TOPMed
rs1590054413 CA378097723	314	G>R		No	ClinGen Ensembl
CA378097774 rs1300551269	316	G>E		No	ClinGen gnomAD
CA5641759 rs139305536	316	G>R		No	ClinGen ESP ExAC gnomAD
rs1240586164 CA378097849	320	A>P		No	ClinGen TOPMed gnomAD
rs1240586164 CA378097855	320	A>T		No	ClinGen TOPMed gnomAD
rs746457576 CA5641762	321	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5641761 rs202230145	321	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5641763 rs770456537	323	R>C		No	ClinGen ExAC TOPMed gnomAD
rs200492698 CA5641764	323	R>H		No	ClinGen ExAC gnomAD
rs769580214 CA5641766 COSM199803	325	E>K	Variant assessed as Somatic; 0.0 impact. oesophagus large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5641767 rs775354653	328	V>A		No	ClinGen ExAC gnomAD
CA212813355 rs112158716	329	L>P		No	ClinGen Ensembl
CA5641768 rs762868906	330	N>H		No	ClinGen ExAC gnomAD
rs763886692 CA5641769	331	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1011275865 CA212813372	333	L>F		No	ClinGen TOPMed
rs1438479522 CA378098050	333	L>P		No	ClinGen gnomAD
rs761695011 CA5641771	334	N>S		No	ClinGen ExAC gnomAD
rs146820785 CA212813390	337	R>G		No	ClinGen ESP TOPMed gnomAD
CA378098120 rs1393139221	337	R>K		No	ClinGen gnomAD
CA212814372 rs74152718 CA5641790	338	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	339	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	340	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378098419 rs1207022289	341	Q>E		No	ClinGen gnomAD
CA5641791 rs768465011	341	Q>H		No	ClinGen ExAC gnomAD
CA5641792 rs375306396	343	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5641793 rs761796742	346	S>C		No	ClinGen ExAC gnomAD
CA5641794 rs187682149	346	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs922426015 CA212814398	346	S>R		No	ClinGen Ensembl
CA5641795 rs771551376	347	P>S		No	ClinGen ExAC gnomAD
rs766541754 CA378098459	348	D>H		No	ClinGen ExAC TOPMed gnomAD
rs766541754 CA5641797	348	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1166435382 CA378098502	354	P>A		No	ClinGen gnomAD
TCGA novel	354	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1298123332 CA378098531	358	V>G		No	ClinGen TOPMed gnomAD
rs903292723 CA212814412	359	G>E		No	ClinGen Ensembl
rs61738505 CA5641799	360	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378098549 rs765633795	362	D>H		No	ClinGen ExAC gnomAD
CA5641800 rs765633795	362	D>Y		No	ClinGen ExAC gnomAD
CA212814429 rs78883140	363	V>G		No	ClinGen Ensembl
rs1356984913 CA378098555	363	V>M		No	ClinGen TOPMed gnomAD
CA378098563 rs1446618805	364	V>G		No	ClinGen TOPMed gnomAD
CA5641802 rs753065700	365	E>D		No	ClinGen ExAC gnomAD
CA5641804 rs778451819	366	R>S		No	ClinGen ExAC TOPMed gnomAD
CA212814472 COSM536877 rs972834758	367	N>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1402054677 CA378098587	368	S>G		No	ClinGen TOPMed
CA5641805 rs200556307	371	L>S		No	ClinGen 1000Genomes ExAC gnomAD
CA5641806 rs760320524	372	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs768250675 CA5641808	374	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1209459742 COSM1504288 CA378098628	374	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	376	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1242942064 CA378098647	377	G>E		No	ClinGen gnomAD
rs1013589692 CA212814495	378	D>H		No	ClinGen Ensembl
TCGA novel	379	W>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378098679 rs1389401722	382	C>G		No	ClinGen gnomAD
rs1564635515 CA378098687	383	G>R		No	ClinGen Ensembl
CA5641811 CA5641810 rs747900647	385	M>I		No	ClinGen ExAC TOPMed
rs774137952 CA5641809	385	M>T		No	ClinGen ExAC TOPMed gnomAD
CA378098699 rs1454538091	385	M>V		No	ClinGen gnomAD
TCGA novel	387	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378098715 rs773157675 CA5641813	387	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1413438647 CA378098716	388	P>T		No	ClinGen gnomAD
rs1185449007 CA378098740	392	R>C		No	ClinGen TOPMed
rs759793937 CA5641816 COSM3686465	392	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs986723325 CA212814533	393	S>C		No	ClinGen TOPMed
CA378098752 rs1364988564	394	N>S		No	ClinGen TOPMed gnomAD
CA378098751 rs1364988564	394	N>T		No	ClinGen TOPMed gnomAD
CA5641819 rs372846468	395	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1590058456 CA378098756	395	T>P		No	ClinGen Ensembl
CA5641818 rs372846468	395	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1343436492 CA378098762	396	S>C		No	ClinGen gnomAD
CA5641820 rs557257815	399	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752079975 CA5641821	401	N>S		No	ClinGen ExAC gnomAD
rs754592693 CA5641825	403	I>K		No	ClinGen ExAC gnomAD
rs778461277 CA5641826	403	I>M		No	ClinGen ExAC TOPMed gnomAD
rs753300933 CA5641824	403	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1195217552 CA378098866	404	Y>*		No	ClinGen gnomAD
rs747927998 CA5641827	404	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA378098855 rs747927998	404	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs368809171 CA5641828	406	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA378098886 rs1244932933	406	S>T		No	ClinGen gnomAD
rs776719484 CA378098921	408	I>M		No	ClinGen ExAC TOPMed gnomAD
CA5641831 rs770917437	408	I>T		No	ClinGen ExAC gnomAD
rs146917199 CA5641830	408	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA378098925 rs1394716596	409	D>N		No	ClinGen gnomAD
CA378098984 rs1325881704	412	N>K		No	ClinGen gnomAD
TCGA novel	413	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM913778 rs759561702 CA5641833	414	E>K	endometrium Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5641836 rs141762300	417	G>S		No	ClinGen ESP ExAC gnomAD
CA5641838 rs764542399	419	S>C		No	ClinGen ExAC TOPMed gnomAD
CA5641840 rs762345381	420	E>K		No	ClinGen ExAC gnomAD
CA378099117 rs1590058657	421	F>V		No	ClinGen Ensembl
CA378099140 rs1590058678	423	Y>F		No	ClinGen Ensembl
rs753340088 CA5641842	424	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1182506905 CA378099172	428	V>M		No	ClinGen gnomAD
rs555052941 CA5641845	430	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5641846 rs778524683	430	R>H		No	ClinGen ExAC TOPMed gnomAD
rs752266858 CA5641847	432	G>V		No	ClinGen ExAC gnomAD
CA5641848 rs758101413	434	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5641849 rs374494342 COSM913779	434	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA378099260 rs1197931722	435	Y>C		No	ClinGen TOPMed
rs770792937 CA5641851	435	Y>H		No	ClinGen ExAC gnomAD
rs1250990140 CA378099301	437	G>E		No	ClinGen TOPMed
rs879255416 RCV000239159	438	P>missing		No	ClinVar dbSNP
TCGA novel	442	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA212814684 rs781507848	443	A>T		No	ClinGen Ensembl
rs781027538 CA5641853	443	A>V		No	ClinGen ExAC gnomAD
CA5641854 rs183633106	444	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769743709 CA5641855	445	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	445	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751195367 CA5641887	448	C>*		No	ClinGen ExAC TOPMed gnomAD
CA378099539 rs1564636535	448	C>G		No	ClinGen Ensembl
CA378099565 rs1247572317	451	A>V		No	ClinGen gnomAD
rs1362830144 CA378099569	452	W>*		No	ClinGen TOPMed gnomAD
rs1362830144 CA378099571	452	W>L		No	ClinGen TOPMed gnomAD
TCGA novel	453	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs182321152 CA5641889	453	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs182321152 CA5641890	453	S>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378099584 rs1590062270	454	V>G		No	ClinGen Ensembl
rs1313831605 CA378099579	454	V>I		No	ClinGen gnomAD
rs1230451286 CA378099588	455	L>P		No	ClinGen gnomAD
rs147079897 CA212815834	457	Q>*		No	ClinGen ESP TOPMed
rs1254834466 COSM3806242 CA378099617	459	F>L	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1350759097 CA378099636	462	G>C		No	ClinGen gnomAD
CA378099634 rs1350759097	462	G>S		No	ClinGen gnomAD
rs1463853923 CA378099663	466	S>*		No	ClinGen gnomAD
rs1370606547 CA378099673	467	H>Q		No	ClinGen TOPMed
rs749340512 CA5641893	469	D>Y		No	ClinGen ExAC gnomAD
CA378099687 rs1308033746	470	E>K		No	ClinGen TOPMed
rs572960933 CA5641894	471	H>P		No	ClinGen 1000Genomes ExAC gnomAD
CA5641896 rs138037225	472	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA5641895 rs138037225	472	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA378099702 rs1197367688	472	R>Q		No	ClinGen TOPMed gnomAD
rs779129729 CA5641915	475	Y>H		No	ClinGen ExAC gnomAD
CA5641917 rs758489093	480	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5641920 rs771309093	482	W>*		No	ClinGen ExAC gnomAD
rs747292114 CA5641919	482	W>L		No	ClinGen ExAC gnomAD
rs1219778509 CA378099789	483	M>V		No	ClinGen gnomAD
CA5641921 rs781598552	485	Q>*		No	ClinGen ExAC gnomAD
CA378099817 rs1483632428	486	V>D		No	ClinGen gnomAD
CA5641922 rs746373610	487	L>S		No	ClinGen ExAC gnomAD
CA378099829 rs1372200616	488	H>Q		No	ClinGen TOPMed
CA5641923 rs538030904	488	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA5641924 rs773795882	492	H>Y		No	ClinGen ExAC gnomAD
rs771584461 CA5641926	494	P>A		No	ClinGen ExAC gnomAD
rs1230933537 CA378099870	494	P>H		No	ClinGen TOPMed
CA5641927 rs772888761	495	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA5641928 rs760293342	496	D>H		No	ClinGen ExAC gnomAD
CA212816865 rs1027956125	501	R>G		No	ClinGen gnomAD
rs1465827116 CA378099915	501	R>Q		No	ClinGen TOPMed gnomAD
CA378099914 rs1027956125	501	R>W		No	ClinGen gnomAD
CA5641930 rs556343062	502	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5641929 rs556343062	502	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378099935 rs1431624299	504	Q>H		No	ClinGen gnomAD
rs759476991 CA5641931	505	L>V		No	ClinGen ExAC TOPMed gnomAD
CA378099942 rs1369457717	506	V>L		No	ClinGen TOPMed gnomAD
CA378099940 rs1369457717	506	V>M		No	ClinGen TOPMed gnomAD
CA5641933 rs373982470	507	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	507	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758532534 CA5641934	508	D>H		No	ClinGen ExAC gnomAD
TCGA novel	508	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777769000 CA5641935	508	D>V		No	ClinGen ExAC gnomAD
rs751797515 CA5641936	509	R>*		No	ClinGen ExAC gnomAD
CA5641937 rs377697566	509	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA378099985 rs1235689604	513	W>R		No	ClinGen TOPMed
rs138413355 COSM1345231 CA5641938	514	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1590064929 CA378100002	515	L>R		No	ClinGen Ensembl
rs770239059 CA5641940	518	I>T		No	ClinGen ExAC gnomAD
rs1014848301 CA212816937	520	Y>C		No	ClinGen TOPMed
rs749800930 CA5641943	523	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5641944 rs201017032	523	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378100053 rs1395505713	524	F>S		No	ClinGen TOPMed
rs1248477072 CA378100052	524	F>V		No	ClinGen gnomAD
CA5641946 rs377604794	526	P>T		No	ClinGen ESP ExAC gnomAD
CA5641965 rs746528122	531	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs374555068 CA5641963	531	R>W		No	ClinGen ESP ExAC gnomAD
CA378100210 rs1439222277	533	E>D		No	ClinGen TOPMed
CA378100215 rs1237709425	534	G>D		No	ClinGen gnomAD
rs553461931 CA5641967	536	R>*		No	ClinGen 1000Genomes ExAC gnomAD
rs553461931 CA5641966	536	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA5641969 rs745552200	536	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5641968 rs745552200	536	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775220542 CA5641970	537	Q>E		No	ClinGen ExAC gnomAD
rs146275364 CA5641971	539	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1437880447 CA378100247	540	G>D		No	ClinGen TOPMed gnomAD
rs368485625 CA5641972	540	G>S		No	ClinGen ESP ExAC TOPMed
CA378100250 rs1423361028	541	S>G		No	ClinGen gnomAD
CA5641973 rs774442084	543	F>Y		No	ClinGen ExAC gnomAD
rs200282153 CA5641974	544	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM239711 rs767625155 CA5641975	544	R>H	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA378100280 rs1289247058	545	L>F		No	ClinGen TOPMed gnomAD
rs1331419393 CA378100282	545	L>P		No	ClinGen gnomAD
rs1289247058 CA378100279	545	L>V		No	ClinGen TOPMed gnomAD
CA378100298 rs1267339709	548	V>I		No	ClinGen gnomAD
CA378100306 rs1451950847	549	Y>H		No	ClinGen TOPMed gnomAD
CA5641978 rs756384852	552	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs756384852 CA5641977	552	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA5641979 rs754156188	553	L>V		No	ClinGen ExAC gnomAD
rs755454118 CA5641980	554	F>V		No	ClinGen ExAC gnomAD
rs779307564 CA5641981	556	A>S		No	ClinGen ExAC gnomAD
rs746475001 CA5641982	558	I>V		No	ClinGen ExAC TOPMed gnomAD
rs745515190 CA5641985	560	V>A		No	ClinGen ExAC gnomAD
CA5641984 rs371471210	560	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5641983 rs371471210	560	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5641986 rs769340182	561	V>L		No	ClinGen ExAC gnomAD
CA378100390 rs1564638138	562	L>P		No	ClinGen Ensembl
rs749062328 CA5641988	563	L>P		No	ClinGen ExAC gnomAD
CA5641991 rs761788182	565	I>N		No	ClinGen ExAC gnomAD
rs774126376 CA5641990	565	I>V		No	ClinGen ExAC
rs772125485 CA5641992	566	F>L		No	ClinGen ExAC gnomAD
CA5641993 rs773346573	568	Y>H		No	ClinGen ExAC gnomAD
CA378100421 rs1590067658	568	Y>S		No	ClinGen Ensembl
rs1456133920 CA378100432	570	L>V		No	ClinGen TOPMed
rs183766876 CA378100438	571	R>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA212817900 rs183766876	571	R>Q		No	ClinGen 1000Genomes TOPMed gnomAD
rs760817453 CA5641994	571	R>W		No	ClinGen ExAC gnomAD
CA378100439 rs766522075	572	L>I		No	ClinGen ExAC gnomAD
CA5641997 rs754180109	573	R>C		No	ClinGen ExAC TOPMed gnomAD
rs754180109 CA5641996	573	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5641998 rs61738520 COSM536874	573	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA212817903 rs61738520	573	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1181065342 CA378100447	574	R>*		No	ClinGen gnomAD
CA212817909 rs1013401025	574	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA378100458 rs1165308056	576	H>D		No	ClinGen gnomAD
rs1412273073 CA378100460	576	H>P		No	ClinGen TOPMed gnomAD
CA378100463 rs1590067748	576	H>Q		No	ClinGen Ensembl
rs1412273073 CA378100462	576	H>R		No	ClinGen TOPMed gnomAD
rs753230686 CA5641999	578	R>*		No	ClinGen ExAC TOPMed gnomAD
CA378100475 rs200214468	578	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5642000 rs200214468	578	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA212817923 rs200382880	579	Q>*		No	ClinGen TOPMed gnomAD
rs780786120 CA5642001	581	R>*		No	ClinGen ExAC TOPMed gnomAD
rs780786120 CA378100489	581	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5642002 rs150584095	581	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378100509 rs1380703981	584	A>V		No	ClinGen TOPMed
rs1037673510 CA212817946	587	D>N		No	ClinGen TOPMed gnomAD
CA378100537 rs1229116834	589	L>M		No	ClinGen TOPMed gnomAD
CA378100538 rs1229116834	589	L>V		No	ClinGen TOPMed gnomAD
CA378100555 rs1276652517	591	L>P		No	ClinGen gnomAD
CA212817961 rs200840103	592	E>*		No	ClinGen TOPMed
rs200840103 CA378100557 COSM3790393	592	E>K	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA378100560 rs1590067866	592	E>V		No	ClinGen Ensembl
CA378100575 rs1262029724	594	V>G		No	ClinGen Ensembl
rs1590067875 CA378100583	595	V>G		No	ClinGen Ensembl
CA378100595 rs1256442141	597	M>I		No	ClinGen gnomAD
CA5642005 rs201253967	597	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA378100591 rs1482637651	597	M>V		No	ClinGen TOPMed
rs768314051 CA5642006	598	M>V		No	ClinGen ExAC gnomAD
CA378100606 rs1184961124	599	G>R		No	ClinGen gnomAD
CA5642007 rs778738545	600	V>A		No	ClinGen ExAC gnomAD
rs778738545 CA5642008	600	V>G		No	ClinGen ExAC gnomAD
CA5642010 rs773217072	603	G>R		No	ClinGen ExAC gnomAD
CA5642011 rs760691867	604	P>L		No	ClinGen ExAC TOPMed gnomAD
rs760691867 CA5642012	604	P>Q		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q9NQZ7

No regional properties for Q9NQZ7

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NQZ7

Functions

		Description
EC Number	3.6.1.15	In phosphorus-containing anhydrides
Subcellular Localization	Cytoplasmic vesicle membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.
endocytic vesicle membrane	The lipid bilayer surrounding an endocytic vesicle.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

7 GO annotations of molecular function

Name	Definition
CTPase activity	Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction.
GDP phosphatase activity	Catalysis of the reaction: GDP + H2O = GMP + phosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding	Binding to a metal ion.
nucleoside diphosphate phosphatase activity	Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate.
ribonucleoside triphosphate phosphatase activity	Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
UDP phosphatase activity	Catalysis of the reaction: UDP + H2O = UMP + phosphate.

8 GO annotations of biological process

Name	Definition
CTP catabolic process	The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate.
GTP metabolic process	The chemical reactions and pathways involving GTP, guanosine triphosphate.
nucleobase-containing small molecule catabolic process	The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
nucleoside diphosphate catabolic process	The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.
regulation of immune response	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
T-helper 17 cell differentiation	The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
UDP catabolic process	The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate.
UTP catabolic process	The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P55772	Entpd1	Ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus (Mouse)	PR
Q3TCT4	Entpd7	Ectonucleoside triphosphate diphosphohydrolase 7	Mus musculus (Mouse)	PR
P97687	Entpd1	Ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MARISFSYLC	PASWYFTVPT	VSPFLRQRVA	FLGLFFISCL	LLLMLIIDFR	HWSASLPRDR
70	80	90	100	110	120
QYERYLARVG	ELEATDTEDP	NLNYGLVVDC	GSSGSRIFVY	FWPRHNGNPH	DLLDIKQMRD
130	140	150	160	170	180
RNSQPVVKKI	KPGISAMADT	PEHASDYLRP	LLSFAAAHVP	VKKHKETPLY	ILCTAGMRLL
190	200	210	220	230	240
PERKQLAILA	DLVKDLPLEF	DFLFSQSQAE	VISGKQEGVY	AWIGINFVLG	RFDHEDESDA
250	260	270	280	290	300
EATQELAAGR	RRTVGILDMG	GASLQIAYEV	PTSTSVLPAK	QEEAAKILLA	EFNLGCDVQH
310	320	330	340	350	360
TEHVYRVYVT	TFLGFGGNFA	RQRYEDLVLN	ETLNKNRLLG	QKTGLSPDNP	FLDPCLPVGL
370	380	390	400	410	420
TDVVERNSQV	LHVRGRGDWV	SCGAMLSPLL	ARSNTSQASL	NGIYQSPIDF	NNSEFYGFSE
430	440	450	460	470	480
FFYCTEDVLR	IGGRYHGPTF	AKAAQDYCGM	AWSVLTQRFK	NGLFSSHADE	HRLKYQCFKS
490	500	510	520	530	540
AWMYQVLHEG	FHFPYDYPNL	RTAQLVYDRE	VQWTLGAILY	KTRFLPLRDL	RQEGVRQAHG
550	560	570	580	590	600
SWFRLSFVYN	HYLFFACILV	VLLAIFLYLL	RLRRIHHRQT	RASAPLDLLW	LEEVVPMMGV

QVGP