Q9N5K2

PR
Gene name
rpb-5 (H27M09.2)
Protein name
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Names
RNA polymerases I, II, and III subunit ABC1, RPB5 homolog
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_H27M09.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9N5K2

Entry ID Method Resolution Chain Position Source
AF-Q9N5K2-F1 Predicted AlphaFoldDB

No variants for Q9N5K2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9N5K2

No associated diseases with Q9N5K2

3 regional properties for Q9N5K2

Type Name Position InterPro Accession
domain RNA polymerase, subunit H/Rpb5 C-terminal 138 - 210 IPR000783
domain RNA polymerase, Rpb5, N-terminal 6 - 95 IPR005571
conserved_site RNA polymerase, subunit H/Rpb5, conserved site 143 - 156 IPR020608

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2T9T3 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 Bos taurus (Bovine) PR
P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 Homo sapiens (Human) PR
Q80UW8 Polr2e DNA-directed RNA polymerases I, II, and III subunit RPABC1 Mus musculus (Mouse) PR
B0BNE2 Polr2e DNA-directed RNA polymerases I, II, and III subunit RPABC1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MADDELETYR LWRIRKTVLQ MVHDRGYLVA QDELDQPLET FKVQYGDRPS EKKPARSDLT
70 80 90 100 110 120
ILVAHNDDPA DQMFVFFPED AKIGIKTIKA ICQQMQEQNI SRAIIVVQTG MTPSAKQSIG
130 140 150 160 170 180
DMAPKYMLEH FLEAELMVNI TEHELVPEHV VMTAEEKAEL LARYKLKDSQ LPRIQQCDPV
190 200 210
ARYFGLRRGQ VVKIIRPSET AGRYITYRLV V