AiPD: Autoinhibited Protein Database

P19388

Gene name	POLR2E
Protein name	DNA-directed RNA polymerases I, II, and III subunit RPABC1
Names	RNA polymerases I, II, and III subunit ABC1, DNA-directed RNA polymerase II 23 kDa polypeptide, DNA-directed RNA polymerase II subunit E, RPB5 homolog, XAP4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5434
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-98 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

3-98 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

34 structures for P19388

Entry ID	Method	Resolution	Chain	Position	Source
5IY6	EM	720 A	E	1-210	PDB
5IY7	EM	860 A	E	1-210	PDB
5IY8	EM	790 A	E	1-210	PDB
5IY9	EM	630 A	E	1-210	PDB
5IYA	EM	540 A	E	1-210	PDB
5IYB	EM	390 A	E	1-210	PDB
5IYC	EM	390 A	E	1-210	PDB
5IYD	EM	390 A	E	1-210	PDB
6DRD	EM	390 A	E	1-210	PDB
6O9L	EM	720 A	E	1-210	PDB
6XRE	EM	460 A	E	1-210	PDB
7A6H	EM	330 A	E	1-210	PDB
7AE1	EM	280 A	E	1-210	PDB
7AE3	EM	310 A	E	1-210	PDB
7AEA	EM	340 A	E	1-210	PDB
7AST	EM	400 A	F	1-210	PDB
7D58	EM	290 A	E	1-210	PDB
7D59	EM	310 A	E	1-210	PDB
7DN3	EM	350 A	E	1-210	PDB
7DU2	EM	335 A	E	1-210	PDB
7FJI	EM	360 A	E	1-210	PDB
7FJJ	EM	360 A	E	1-210	PDB
7LBM	EM	480 A	E	1-210	PDB
7OB9	EM	270 A	E	1-210	PDB
7OBA	EM	310 A	E	1-210	PDB
7OBB	EM	330 A	E	1-210	PDB
7VBA	EM	289 A	E	1-210	PDB
7VBB	EM	281 A	E	1-210	PDB
7VBC	EM	301 A	E	1-210	PDB
8A43	EM	409 A	E	1-210	PDB
8ITY	EM	390 A	E	1-210	PDB
8IUE	EM	410 A	E	1-210	PDB
8IUH	EM	340 A	E	1-210	PDB
AF-P19388-F1	Predicted				AlphaFoldDB

205 variants for P19388

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA403039726 rs1241827029	2	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs779992371 CA403039700	3	D>A		No	ClinGen ExAC gnomAD
CA304051048 rs372837141	3	D>E		No	ClinGen ESP TOPMed gnomAD
CA9037070 rs779992371	3	D>V		No	ClinGen ExAC gnomAD
rs148531513 CA9037071	3	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1168315618 CA403039677	4	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA403039681 rs1427372746	4	E>G		No	ClinGen TOPMed
rs758201698 CA9037069	6	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	6	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9037068 rs750105802	6	E>D		No	ClinGen ExAC TOPMed gnomAD
CA403039624 rs1456332319	7	T>M		No	ClinGen gnomAD
CA9037067 rs778381561	7	T>P		No	ClinGen ExAC gnomAD
CA403039592 rs531296731	8	Y>*		No	ClinGen TOPMed gnomAD
rs144085491 CA304051025	9	R>Q		No	ClinGen ESP
CA9037065 rs753258227	9	R>W		No	ClinGen ExAC TOPMed gnomAD
rs760026410 CA9037063	10	L>P		No	ClinGen ExAC gnomAD
CA9037061 rs570436933	13	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1362799688 CA403039522	13	I>V		No	ClinGen TOPMed
CA403039474 rs1207334502	14	R>C		No	ClinGen TOPMed gnomAD
rs748732500 CA304051005	15	K>E		No	ClinGen Ensembl
rs748732500 CA403039464	15	K>Q		No	ClinGen Ensembl
CA9037060 rs149504848	15	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9037058 rs376699715	17	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9037056 rs776836766	18	M>L		No	ClinGen ExAC TOPMed gnomAD
CA403038542 rs1225175422	21	C>S		No	ClinGen gnomAD
CA9037025 rs747622772	23	D>E		No	ClinGen ExAC gnomAD
rs138106261 CA9037026	23	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs138106261 CA403038520	23	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs780585471 CA9037024	24	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9037023 rs200794578	24	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA403038414 rs1402555063	28	V>M		No	ClinGen gnomAD
rs765523565 CA9037021	30	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs1017622535 CA304050005	30	Q>R		No	ClinGen TOPMed
rs754136230 CA403038332	31	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9037018 rs764372975	32	E>*		No	ClinGen ExAC gnomAD
CA403038323 rs764372975	32	E>K		No	ClinGen ExAC gnomAD
CA403038249 rs760879470	34	D>A		No	ClinGen ExAC gnomAD
rs1234676505 CA403038256	34	D>H		No	ClinGen gnomAD
CA9037017 rs760879470	34	D>V		No	ClinGen ExAC gnomAD
rs747356975 CA304050000	35	Q>*		No	ClinGen Ensembl
rs752805743 CA9037016	36	T>A		No	ClinGen ExAC gnomAD
CA403038218 rs752805743	36	T>P		No	ClinGen ExAC gnomAD
rs767550886 CA9037015	38	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1267200270 CA403038144	39	E>*		No	ClinGen TOPMed gnomAD
rs914404373 CA304049986	39	E>D		No	ClinGen TOPMed
rs1267200270 CA403038137	39	E>K		No	ClinGen TOPMed gnomAD
rs1280634728 CA403038114	40	F>I		No	ClinGen TOPMed
rs759391950 CA9037014	40	F>L		No	ClinGen ExAC TOPMed gnomAD
CA9037012 rs12459404	44	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9037011 rs12459404 VAR_028259	44	S>F		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA304049947 rs12459404	44	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs953210323 CA304049936	45	G>R		No	ClinGen Ensembl
rs772889135 CA9037010	46	D>E		No	ClinGen ExAC gnomAD
rs769410946 CA9037009	48	P>S		No	ClinGen ExAC gnomAD
CA9037007 rs141821175	49	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs976132861 CA304049922	52	R>Q		No	ClinGen TOPMed gnomAD
rs1406420756 CA403037891	52	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9037004 rs779428291	53	P>L	Variant assessed as Somatic; 4.631e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1185676987 CA403037868	54	R>Q		No	ClinGen gnomAD
rs1385893793 CA403037874	54	R>W		No	ClinGen gnomAD
rs1463669532 CA403037853	55	R>C		No	ClinGen gnomAD
rs1247192486 CA403037852	55	R>H		No	ClinGen TOPMed gnomAD
rs1287704982 CA403037795	60	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs767504005 CA9036998	66	D>N		No	ClinGen ExAC gnomAD
rs767504005 CA304049853	66	D>Y		No	ClinGen ExAC gnomAD
CA403037706 rs1599797438	67	D>A		No	ClinGen Ensembl
rs1023720886 CA304049849	69	T>I		No	ClinGen TOPMed
CA403037668 rs1219492381	70	D>A		No	ClinGen TOPMed
rs1431991339 CA403037663	70	D>E		No	ClinGen TOPMed gnomAD
CA403037671 rs367830828	70	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9036996 rs367830828	70	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs766305951 CA9036995	73	F>L		No	ClinGen ExAC gnomAD
CA9036994 rs762783062	73	F>S		No	ClinGen ExAC gnomAD
CA9036993 rs772976015	74	V>G		No	ClinGen ExAC
CA403037619 rs1309943323	74	V>L		No	ClinGen TOPMed
rs1241615239 CA403037607	75	F>S		No	ClinGen TOPMed
rs1366284293 CA403037583	77	P>A		No	ClinGen gnomAD
CA304049811 rs1043388313	77	P>L		No	ClinGen TOPMed
CA403037575 rs1205375394	78	E>K		No	ClinGen gnomAD
rs140799064 CA9036920	79	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140799064 CA403036655	79	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1303663913 CA403036635	80	P>L		No	ClinGen gnomAD
CA403036632 rs1368117488	81	K>E		No	ClinGen gnomAD
TCGA novel	83	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403036594 COSM3932870 rs1462124845	83	G>D	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA9036917 rs770852587	84	I>T		No	ClinGen ExAC gnomAD
rs1479652332 CA403036159	85	K>R		No	ClinGen TOPMed gnomAD
rs1200746815 CA403036095	88	K>N		No	ClinGen gnomAD
CA9036914 rs377252494	90	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403036060 rs1340238529	90	Y>C		No	ClinGen TOPMed gnomAD
CA403036072 rs1195457733	90	Y>N		No	ClinGen gnomAD
CA403036039 rs1322523360	91	C>F		No	ClinGen gnomAD
rs1230869145 CA403036045	91	C>S		No	ClinGen TOPMed gnomAD
CA304047531 rs371458354	92	Q>*		No	ClinGen ESP TOPMed gnomAD
TCGA novel CA403036013 rs1599794368	93	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA403036008 rs1406642489	93	R>H		No	ClinGen gnomAD
rs1348100349 CA403036002	94	M>L		No	ClinGen gnomAD
CA403035995 rs1235720112	94	M>T		No	ClinGen TOPMed
CA403036000 rs1348100349	94	M>V		No	ClinGen gnomAD
rs767944502	97	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs753673585 CA9036911	98	N>S		No	ClinGen ExAC gnomAD
CA403035903 rs1428982211	99	I>L		No	ClinGen gnomAD
CA9036908 rs143781514	100	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372313949 CA304047515	101	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA9036907 rs148984381	101	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760011436 CA9036906	102	A>S		No	ClinGen ExAC gnomAD
CA403035855 rs1252974003	102	A>V		No	ClinGen TOPMed gnomAD
CA403035851 rs1460721946	103	L>V		No	ClinGen TOPMed gnomAD
CA403035835 rs1225272071	104	I>T		No	ClinGen gnomAD
rs147921895 COSM1221506 CA9036903	105	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs913013040 CA304047460	106	V>A		No	ClinGen TOPMed
CA403035804 rs1568513176	107	Q>E		No	ClinGen Ensembl
rs774004270 CA9036902	108	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs1160814656 CA403035736	109	G>V		No	ClinGen TOPMed
rs762729935 CA9036900	110	M>K		No	ClinGen ExAC gnomAD
rs144928792 CA9036901	110	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA304047448 rs1028649314	112	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1028649314 CA403035675	112	P>T		No	ClinGen TOPMed gnomAD
CA403035646 rs1471158981	113	S>F		No	ClinGen gnomAD
rs1337729311 CA403035659	113	S>P		No	ClinGen gnomAD
rs1599794193 CA403035630	114	A>D		No	ClinGen Ensembl
CA9036897 rs11541898	114	A>S		No	ClinGen ExAC TOPMed gnomAD
rs11541898 CA304047442	114	A>T		No	ClinGen ExAC TOPMed gnomAD
CA304047429 rs963286964	115	K>N		No	ClinGen TOPMed gnomAD
CA403035610 rs1470570762	115	K>R		No	ClinGen gnomAD
rs770934264 CA9036895 CA9036896	116	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs897938139 CA304046390	117	S>F		No	ClinGen gnomAD
rs765020060 CA9036848	119	V>A		No	ClinGen ExAC gnomAD
CA9036845 COSM178112 rs766399285	120	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs985055030 CA304046351	121	M>T		No	ClinGen TOPMed
rs11959 CA304046345	123	P>A		No	ClinGen Ensembl
rs1319472959 CA403035053	126	I>L		No	ClinGen TOPMed
CA9036838 rs749600755	132	Q>*		No	ClinGen ExAC gnomAD
rs752979834 CA304046273	135	L>P		No	ClinGen TOPMed gnomAD
rs780513362 CA9036837	137	I>V		No	ClinGen ExAC TOPMed gnomAD
CA403034784 COSM990700 rs1197571602	138	N>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA9036836 rs770251481	138	N>S		No	ClinGen ExAC gnomAD
rs948584739 CA304046242	140	T>K		No	ClinGen TOPMed
rs948584739 CA304046238	140	T>M		No	ClinGen TOPMed
rs1480683312 CA403034703	142	H>D		No	ClinGen gnomAD
rs61740611 CA304046227	142	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1445652128 CA403033540	146	P>A		No	ClinGen gnomAD
rs779847415 CA403033459	149	V>F		No	ClinGen ExAC gnomAD
rs779847415 CA9036788	149	V>I		No	ClinGen ExAC gnomAD
CA9036785 rs374965254	150	V>I		No	ClinGen ESP ExAC gnomAD
rs374965254 CA9036786	150	V>L		No	ClinGen ESP ExAC gnomAD
CA403033393 rs1246920956	151	M>T		No	ClinGen gnomAD
rs757099189 CA9036784	151	M>V		No	ClinGen ExAC TOPMed gnomAD
CA9036783 rs751535306	152	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1381438320 CA403033276	155	E>D		No	ClinGen gnomAD
CA403033295 rs1293095773	155	E>K		No	ClinGen gnomAD
rs1183728535 CA403033281	155	E>V		No	ClinGen TOPMed
rs1364101114 CA403033272	156	V>M		No	ClinGen TOPMed
CA9036782 rs764019574	159	L>P		No	ClinGen ExAC TOPMed gnomAD
CA9036781 rs758504093	160	L>P		No	ClinGen ExAC gnomAD
CA9036779 rs759797327	162	R>*		No	ClinGen ExAC gnomAD
CA9036780 rs759797327	162	R>G		No	ClinGen ExAC gnomAD
CA9036777 rs369309356	162	R>P		No	ClinGen ESP ExAC gnomAD
rs369309356 CA403033143	162	R>Q		No	ClinGen ESP ExAC gnomAD
rs1158509033 CA403032626	165	L>R		No	ClinGen gnomAD
CA9036704 rs200525559	165	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs201275503 CA9036703	166	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA304044822 rs1055376064	166	R>P		No	ClinGen TOPMed
CA304044821 rs972569097	169	Q>*		No	ClinGen TOPMed
rs150847384 CA9036700	169	Q>H		No	ClinGen ESP ExAC gnomAD
rs1239129584 CA403032316	173	I>T		No	ClinGen gnomAD
rs939539104 CA304044804	175	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs769774420 CA9036697	177	D>N		No	ClinGen ExAC gnomAD
CA9036696 rs746033391	177	D>V		No	ClinGen ExAC
CA403032182 rs769774420	177	D>Y		No	ClinGen ExAC gnomAD
rs1416603100 CA403032121	178	P>R		No	ClinGen gnomAD
CA9036695 rs781556560	178	P>S		No	ClinGen ExAC TOPMed gnomAD
rs781556560 CA403032134	178	P>T		No	ClinGen ExAC TOPMed gnomAD
CA403032108 rs1382890907	179	V>L		No	ClinGen TOPMed gnomAD
rs757607222 CA9036694	180	A>S		No	ClinGen ExAC gnomAD
rs906660666 CA304044801	180	A>V		No	ClinGen gnomAD
rs778316755 CA9036692	181	R>C		No	ClinGen ExAC TOPMed gnomAD
CA403032039 rs1443797421	181	R>P		No	ClinGen gnomAD
rs1189540314 CA403032015	182	Y>H		No	ClinGen TOPMed gnomAD
rs1261855355 CA403032011	182	Y>S		No	ClinGen TOPMed gnomAD
rs1015048713 CA304044771	184	G>W		No	ClinGen TOPMed
rs1445278539 CA403031852	185	I>M		No	ClinGen gnomAD
rs142308779 CA9036690	187	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA304044765 rs945424553	187	R>H		No	ClinGen TOPMed gnomAD
rs945424553 CA403031784	187	R>P		No	ClinGen TOPMed gnomAD
CA9036689 rs139328030	188	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9036687 rs749995612	189	Q>K		No	ClinGen ExAC gnomAD
rs748440861 CA9036651	191	V>A		No	ClinGen ExAC gnomAD
rs370150594 CA9036650	195	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1281904434 CA403030649	195	R>W	Variant assessed as Somatic; 9.241e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9036649 rs769002822	196	P>S		No	ClinGen ExAC gnomAD
rs780622181 CA9036647	199	T>M		No	ClinGen ExAC TOPMed gnomAD
CA403030493 rs1331871882	201	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9036645 rs375882249	203	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs758116915 CA9036643	205	T>I		No	ClinGen ExAC gnomAD
CA403030412 rs1599790547	205	T>P		No	ClinGen Ensembl
CA403030346 rs759491281	207	R>L		No	ClinGen ExAC TOPMed gnomAD
rs759491281 CA9036640	207	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA304044115 rs372881876	207	R>W		No	ClinGen ESP TOPMed gnomAD
rs753834886 CA9036639	209	V>G		No	ClinGen ExAC gnomAD
CA9036638 rs766492286	210	Q>E		No	ClinGen ExAC
rs773392791 CA9036636	210	Q>H		No	ClinGen ExAC gnomAD
rs760824411 CA9036637	210	Q>R		No	ClinGen ExAC gnomAD
CA304044075 rs967342267	211	Q>Q		No	ClinGen TOPMed gnomAD
rs772154822 CA9036635	211	Q>Y		No	ClinGen ExAC gnomAD

No associated diseases with P19388

3 regional properties for P19388

Type	Name	Position	InterPro Accession
domain	RNA polymerase, subunit H/Rpb5 C-terminal	137 - 209	IPR000783
domain	RNA polymerase, Rpb5, N-terminal	4 - 94	IPR005571
conserved_site	RNA polymerase, subunit H/Rpb5, conserved site	142 - 155	IPR020608

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase I complex	RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase II, core complex	RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase III complex	RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RPAP3/R2TP/prefoldin-like complex	A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.

2 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity	Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

2 GO annotations of biological process

Name	Definition
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9T3	POLR2E	DNA-directed RNA polymerases I, II, and III subunit RPABC1	Bos taurus (Bovine)	PR
Q80UW8	Polr2e	DNA-directed RNA polymerases I, II, and III subunit RPABC1	Mus musculus (Mouse)	PR
B0BNE2	Polr2e	DNA-directed RNA polymerases I, II, and III subunit RPABC1	Rattus norvegicus (Rat)	PR
Q9N5K2	rpb-5	DNA-directed RNA polymerases I, II, and III subunit RPABC1	Caenorhabditis elegans	PR

10	20	30	40	50	60
MDDEEETYRL	WKIRKTIMQL	CHDRGYLVTQ	DELDQTLEEF	KAQSGDKPSE	GRPRRTDLTV
70	80	90	100	110	120
LVAHNDDPTD	QMFVFFPEEP	KVGIKTIKVY	CQRMQEENIT	RALIVVQQGM	TPSAKQSLVD
130	140	150	160	170	180
MAPKYILEQF	LQQELLINIT	EHELVPEHVV	MTKEEVTELL	ARYKLRENQL	PRIQAGDPVA
190	200
RYFGIKRGQV	VKIIRPSETA	GRYITYRLVQ