Q9MYZ9

PR
Gene name
EPOR
Protein name
Erythropoietin receptor
Names
TR, TfR, TfR1, Trfr, EPO-R
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397554
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

442-509 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9MYZ9

Entry ID Method Resolution Chain Position Source
AF-Q9MYZ9-F1 Predicted AlphaFoldDB

5 variants for Q9MYZ9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs790765758 20 A>S No EVA
rs321721168 92 H>R No EVA
rs787672563 136 R>L No EVA
rs706999943 300 T>N No EVA
rs697020881 438 R>H No EVA

No associated diseases with Q9MYZ9

3 regional properties for Q9MYZ9

Type Name Position InterPro Accession
conserved_site Long hematopoietin receptor, single chain, conserved site 163 - 243 IPR003528
domain Fibronectin type III 146 - 248 IPR003961
domain Growth hormone/erythropoietin receptor, ligand binding 37 - 141 IPR015152

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

3 GO annotations of molecular function

Name Definition
cytokine receptor activity Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
erythropoietin receptor activity Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
identical protein binding Binding to an identical protein or proteins.

6 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
decidualization The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19235 EPOR Erythropoietin receptor Homo sapiens (Human) PR
Q08351 Mpl Thrombopoietin receptor Mus musculus (Mouse) PR
P14753 Epor Erythropoietin receptor Mus musculus (Mouse) PR
10 20 30 40 50 60
MYHFGATLWP GVGSLCLLLA GATWAPSPNS PDAKFESKAA LLAARGPEEL LCFTERLEDL
70 80 90 100 110 120
VCFWEEAGSA GVGPEDYSFS YQLEGEPWKP CHLHQGPTAR GSVRFWCSLP TADTSSFVPL
130 140 150 160 170 180
ELRVTEVSSG APRYHRIIHI NEVVLLDPPA GLLARRAEES GHVVLRWLPP PGAPMASLIR
190 200 210 220 230 240
YEVNISTENA AGGVQRVEIL DGRTECVLSN LRGGTRYTFM VRARMAEPSF GGFWSAWSEP
250 260 270 280 290 300
ASLLTASDLD PLILTLSLIL VLILLLLAVL ALLSHRRTLK QKIWPGIPSP EGEFEGLFTT
310 320 330 340 350 360
HKGNFQLWLY QTDGCLWWSP CTPFAEDPPA PLEVLSERCW GVTQAVEPAA DDEGSLLEPV
370 380 390 400 410 420
GSEHARDTYL VLDKWLLPRR PASEDLPQPG GDLDMAAMDE ASEASFCSSA LALKPGPEGA
430 440 450 460 470 480
SAASFEYTIL DPSSQLLRPR ALPAELPPTP PHLKYLYLVV SDSGISTDYS SGGSQETQGG
490 500
SSSGPYSNPY ENSLVPAPEP SPPNYVTCS