Q9MYZ3

PR
Gene name
TFRC
Protein name
Transferrin receptor protein 1
Names
Species
Felis catus (Cat) (Felis silvestris catus)
KEGG Pathway
fca:493880
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-196 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9MYZ3

Entry ID Method Resolution Chain Position Source
AF-Q9MYZ3-F1 Predicted AlphaFoldDB

No variants for Q9MYZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9MYZ3

No associated diseases with Q9MYZ3

4 regional properties for Q9MYZ3

Type Name Position InterPro Accession
domain PA domain 237 - 354 IPR003137
domain Transferrin receptor-like, dimerisation domain 647 - 758 IPR007365
domain Peptidase M28 397 - 585 IPR007484
domain Transferrin receptor protein 1/2, PA domain 211 - 386 IPR037324

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.

1 GO annotations of molecular function

Name Definition
transferrin receptor activity Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.

7 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
iron ion transport The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of isotype switching Any process that activates or increases the frequency, rate or extent of isotype switching.
positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation.
receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
transferrin transport The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9GLD3 TFRC Transferrin receptor protein 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q2V905 TFRC Transferrin receptor protein 1 Equus caballus (Horse) PR
Q62351 Tfrc Transferrin receptor protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MMDQARSAFS TLFGGEPLSY TRFSLARQVD GDNSHVEMKL AADEEENVDN NMRDNGASVT
70 80 90 100 110 120
KPKRFNGFIC YGTIAIILFF LIGFMIGYLG YCKRVEAKSE CERPAGTESL EVEGTEPSET
130 140 150 160 170 180
EEYFPEAPSH LFWSDLKTML SEKLSNTEFT STIRQLNENS YFPREAGSQK DESLAFFIEN
190 200 210 220 230 240
RFRELQLSKA WHDEHFVKVQ VKGSASNSVT IVGTNSGMVY LVESPEGYVA YSKAATVTGR
250 260 270 280 290 300
LVHANFGTKK DFENLNSPVN GSLVIVRAGK ITFAEKVANA ESFNAIGVLI YMDQAKFPIT
310 320 330 340 350 360
NAEIPFFGHA HLGTGDPYTP GFPSFNHTQF PPSQSSGLPN IPVQTISRAN AEKLFGNMEG
370 380 390 400 410 420
DCPSAWETDS SCRLETSRNW NVKLSVNNVL KEIRIFNVFG VIKGFEEPDH YVVVGAQRDA
430 440 450 460 470 480
WGPGAAKSSV GTALLLELAR ILSDMVLKGG FKPSRSIVFA SWSAGDFGAV GATEWLEGYL
490 500 510 520 530 540
SSLHLKAFTY INLDKAVLGT SNFKVSASPL LYSLIEKVMK DVKHPVTGQS LYRDSNWINK
550 560 570 580 590 600
VEKFSLDNAA FPFLAYSGIP AVSFCFCEDT DYPYLGTTMD VYEKLIQKVP QLNKMARAAA
610 620 630 640 650 660
EVAGQLIMKL TYDLELNLNY EMYNDKILSF VRDVSRFRAD IKEMGLNLQW LYSARGDFFR
670 680 690 700 710 720
ATSRLTTDYR NAERTNRFIM RDINDRIMRV EYHFLSPYVS PRESPFRHIF WGTGSHTLSA
730 740 750 760
LLEHLKLRQE NISAFNETLF RNQLALTTWT IQGAANALSG DIWDIDNEF