Q9GLD3

PR
Gene name
TFRC
Protein name
Transferrin receptor protein 1
Names
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403703
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9GLD3

Entry ID Method Resolution Chain Position Source
AF-Q9GLD3-F1 Predicted AlphaFoldDB

No variants for Q9GLD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9GLD3

No associated diseases with Q9GLD3

4 regional properties for Q9GLD3

Type Name Position InterPro Accession
domain PA domain 238 - 355 IPR003137
domain Transferrin receptor-like, dimerisation domain 648 - 759 IPR007365
domain Peptidase M28 398 - 589 IPR007484
domain Transferrin receptor protein 1/2, PA domain 212 - 387 IPR037324

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transferrin receptor activity Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.

6 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of isotype switching Any process that activates or increases the frequency, rate or extent of isotype switching.
positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation.
receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
transferrin transport The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9MYZ3 TFRC Transferrin receptor protein 1 Felis catus (Cat) (Felis silvestris catus) PR
Q2V905 TFRC Transferrin receptor protein 1 Equus caballus (Horse) PR
Q62351 Tfrc Transferrin receptor protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MMDQARSAFS TLFGGEPLSY TRFSLARQVD GDNSHVEMKL AADEEENVDN NMRGNHASVP
70 80 90 100 110 120
KPKRCNGFIC YGTIAVVLFF LIGFMIGYLG YCKRVEPKAG CERPTGTEAL GTERTEPSET
130 140 150 160 170 180
EEYFPETPSR LFWTDLKTML SERLSNTDFT NTMRWLNENS YVPREAGSQK DESLALLIEN
190 200 210 220 230 240
RFREFQLSKS WRDEHFVEIQ VKSSNAQNTV TIVDMESDLV YLAESPEGYV AYSKATTVTG
250 260 270 280 290 300
RLVHVNFGTK KDFENLKSPV NGSLVIARAG KITFAEKVAN AQSYNALGVL IYMDQARFPI
310 320 330 340 350 360
VNARIPFFGH AHLGTGDPYT PGFPSFNHTQ FPPSQSSGLP SIPVQTISRA AAEKLFENME
370 380 390 400 410 420
GDCPSAWEID PSCRLETSSN KNVNLTVNNV LKEIRIFNVF GVIKGFEEPD RYVVIGAQRD
430 440 450 460 470 480
AWGPGAAKSS VGTALLLELA RIFSDMVLKG GFKPSRSIVF ASWSAGDFGA IGATEWLEGY
490 500 510 520 530 540
LSSLHLKAFT YINLDKAILG TSNFKVSASP LLYSLLEKTM KDVKHPITGQ SLYRDSNWIN
550 560 570 580 590 600
KVEKLSLDNA AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DLYENLNQKI PQLNKMARGA
610 620 630 640 650 660
AEVAGQLIMK LTYDLELNLN YEMYNDRILS FVRDMNQFRT DIKEMGLNLQ WLYSARGDFF
670 680 690 700 710 720
RATSRLTTDY KNAERTNRFV MREINDRIMK VEHNFLSPYV SPRDSPFRHI FWGSGSHTLP
730 740 750 760
ALVEHLKLRQ KNKSAFNETL LRNQLALATW TIQGAANALS GDIWDIDNEF