Q9MBA1

PR
Gene name
CAO (CHL, At1g44446, T18F15.7)
Protein name
Chlorophyllide a oxygenase, chloroplastic
Names
Chlorophyll a oxygenase, Chlorophyll b synthase, AtCAO
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G44446
EC number
1.14.13.122: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-240 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9MBA1

Entry ID Method Resolution Chain Position Source
AF-Q9MBA1-F1 Predicted AlphaFoldDB

26 variants for Q9MBA1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04865775 8 P>A No 1000Genomes
tmp_1_16851100_G_A 18 S>F No 1000Genomes
ENSVATH04865773 20 T>S No 1000Genomes
tmp_1_16851088_G_T 22 S>Y No 1000Genomes
ENSVATH01288469 52 S>I No 1000Genomes
ENSVATH13359805 75 L>I No 1000Genomes
ENSVATH04865752 135 E>K No 1000Genomes
tmp_1_16850338_G_C 140 A>G No 1000Genomes
ENSVATH04865745 156 D>V No 1000Genomes
tmp_1_16850190_T_G 163 E>D No 1000Genomes
tmp_1_16850158_A_T 174 V>D No 1000Genomes
ENSVATH04865743 185 T>S No 1000Genomes
ENSVATH04865742 187 A>V No 1000Genomes
ENSVATH04865741 197 T>I No 1000Genomes
tmp_1_16850077_G_T 201 A>E No 1000Genomes
ENSVATH01288442 222 Y>F No 1000Genomes
tmp_1_16849991_G_A 230 L>F No 1000Genomes
ENSVATH01288423 315 Q>K No 1000Genomes
ENSVATH04865720 334 S>T No 1000Genomes
ENSVATH14221807 348 V>A No 1000Genomes
tmp_1_16849298_C_T 379 G>D No 1000Genomes
ENSVATH01288405 392 T>S No 1000Genomes
ENSVATH04865705 448 S>C No 1000Genomes
tmp_1_16849006_T_C 451 K>R No 1000Genomes
ENSVATH04865702 479 F>Y No 1000Genomes
tmp_1_16848669_C_T 536 G>S No 1000Genomes

No associated diseases with Q9MBA1

4 regional properties for Q9MBA1

Type Name Position InterPro Accession
domain Pheophorbide a oxygenase 408 - 502 IPR013626
binding_site Aromatic-ring-hydroxylating dioxygenase, 2Fe-2S-binding site 262 - 284 IPR015881
domain Rieske [2Fe-2S] iron-sulphur domain 221 - 321 IPR017941
domain Vanillate O-demethylase oxygenase-like, C-terminal catalytic domain 354 - 378 IPR044043

Functions

Description
EC Number 1.14.13.122 With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Plastid, chloroplast membrane ; Peripheral membrane protein
  • Plastid, chloroplast thylakoid membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma.
chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
thylakoid membrane The pigmented membrane of any thylakoid.

4 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
chlorophyllide a oxygenase [overall] activity Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+.
iron ion binding Binding to an iron (Fe) ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8S7E1 CAO Chlorophyllide a oxygenase, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9FYC2 PAO Pheophorbide a oxygenase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNAAVFSPSA LSLPISFSKT RSSFLSRKKG VKGEFRVFAV FGDESGLVEK KSQWRPLFDV
70 80 90 100 110 120
EDPRSKAPPY KGKFLDVNQA IEVARFDIQY LDWRARQDLL TIMILHDKVV DVLNPLAREY
130 140 150 160 170 180
KSIGTVKKEL AGLQEELSKA HQQVHISEAR VSTALDKLAH MEELVNDRLL PGRVVTELDK
190 200 210 220 230 240
PSSSTTASAV ELDREKTNTG AKSLNVSGPV PPYSPHLKNF WYPVAFTADL KHDTMVPIEC
250 260 270 280 290 300
FEQPWVIFRG EDGKPGCVRN TCAHRACPLD LGTVNEGRIQ CPYHGWEYST DGECKKMPST
310 320 330 340 350 360
KLLKVKIKSL PCLEQEGMIW IWPGDEPPAP ILPSLQPPSG FLIHAELVMD LPVEHGLLLD
370 380 390 400 410 420
NLLDLAHAPF THTSTFAKGW SVPSLVKFLT PTSGLQGYWD PYPIDMEFKP PCIVLSTIGI
430 440 450 460 470 480
SKPGKLEGKS TQQCATHLHQ LHVCLPSSKN KTRLLYRMSL DFAPILKNLP FMEHLWRHFA
490 500 510 520 530
EQVLNEDLRL VLGQQERMLN GANIWNLPVA YDKLGVRYRL WRNAVDRGDD KLPFSG