Q9FYC2
PR
Gene name |
PAO (ACD1, At3g44880, F28D10_70) |
Protein name |
Pheophorbide a oxygenase, chloroplastic |
Names |
AtPaO, Pheide a oxygenase, Accelerated cell death 1, Lethal leaf-spot 1 homolog, Lls1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G44880 |
EC number |
1.14.15.17: With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FYC2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FYC2-F1 | Predicted | AlphaFoldDB |
73 variants for Q9FYC2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_16383895_T_C | 13 | I>T | No | 1000Genomes | |
| ENSVATH12466654 | 19 | K>T | No | 1000Genomes | |
| ENSVATH12466665 | 25 | S>F | No | 1000Genomes | |
| ENSVATH06218116 | 26 | P>H | No | 1000Genomes | |
| ENSVATH06218117 | 29 | K>N | No | 1000Genomes | |
| ENSVATH12466667 | 41 | S>P | No | 1000Genomes | |
| ENSVATH00398702 | 45 | H>N | No | 1000Genomes | |
| tmp_3_16383996_C_T | 47 | P>S | No | 1000Genomes | |
| ENSVATH06218118 | 49 | R>H | No | 1000Genomes | |
| ENSVATH06218119 | 52 | A>P | No | 1000Genomes | |
| tmp_3_16384024_T_C | 56 | V>A | No | 1000Genomes | |
| ENSVATH02424653 | 56 | V>I | No | 1000Genomes | |
| tmp_3_16384038_T_A | 61 | S>T | No | 1000Genomes | |
| ENSVATH00398703 | 62 | T>A | No | 1000Genomes | |
| tmp_3_16384049_G_C | 64 | E>D | No | 1000Genomes | |
| ENSVATH06218121 | 65 | K>N | No | 1000Genomes | |
| ENSVATH02424654 | 69 | E>D | No | 1000Genomes | |
| ENSVATH06218122 | 70 | E>G | No | 1000Genomes | |
| tmp_3_16384092_G_T | 79 | G>W | No | 1000Genomes | |
| ENSVATH06218124 | 85 | R>K | No | 1000Genomes | |
| ENSVATH14357609 | 94 | V>L | No | 1000Genomes | |
| ENSVATH12466668 | 109 | G>A | No | 1000Genomes | |
| ENSVATH14357610 | 114 | L>I | No | 1000Genomes | |
| ENSVATH14357611 | 137 | L>F | No | 1000Genomes | |
| ENSVATH02424676 | 158 | G>S | No | 1000Genomes | |
| ENSVATH06218140 | 160 | C>Y | No | 1000Genomes | |
| tmp_3_16384671_A_G | 171 | T>A | No | 1000Genomes | |
| tmp_3_16384672_C_A | 171 | T>N | No | 1000Genomes | |
| ENSVATH12466745 | 176 | A>T | No | 1000Genomes | |
| ENSVATH12466746 | 187 | I>M | No | 1000Genomes | |
| tmp_3_16384738_T_C | 193 | V>A | No | 1000Genomes | |
| ENSVATH02424679 | 199 | F>L | No | 1000Genomes | |
| ENSVATH12466747 | 201 | W>L | No | 1000Genomes | |
| ENSVATH12466748 | 203 | D>E | No | 1000Genomes | |
| tmp_3_16384767_G_A | 203 | D>N | No | 1000Genomes | |
| ENSVATH06218149 | 226 | E>Q | No | 1000Genomes | |
| ENSVATH12466769 | 229 | T>M | No | 1000Genomes | |
| ENSVATH06218151 | 271 | P>A | No | 1000Genomes | |
| tmp_3_16385160_A_C | 273 | K>T | No | 1000Genomes | |
| ENSVATH06218152 | 283 | Q>L | No | 1000Genomes | |
| ENSVATH12466788 | 291 | R>K | No | 1000Genomes | |
| tmp_3_16385220_C_T | 293 | T>I | No | 1000Genomes | |
| tmp_3_16385349_A_C | 308 | L>F | No | 1000Genomes | |
| ENSVATH06218156 | 310 | A>V | No | 1000Genomes | |
| tmp_3_16385371_G_A | 316 | G>S | No | 1000Genomes | |
| tmp_3_16385375_A_G | 317 | N>S | No | 1000Genomes | |
| ENSVATH06218157 | 318 | Q>K | No | 1000Genomes | |
| ENSVATH12466829 | 348 | Q>P | No | 1000Genomes | |
| tmp_3_16385641_G_A | 382 | G>R | No | 1000Genomes | |
| ENSVATH02424712 | 389 | A>S | No | 1000Genomes | |
| ENSVATH02424713 | 391 | S>A | No | 1000Genomes | |
| ENSVATH00398720 | 396 | D>G | No | 1000Genomes | |
| ENSVATH12466833 | 398 | D>N | No | 1000Genomes | |
| ENSVATH06218159 | 402 | Q>L | No | 1000Genomes | |
| ENSVATH02424714 | 438 | T>N | No | 1000Genomes | |
| ENSVATH06218165 | 439 | P>L | No | 1000Genomes | |
| ENSVATH06218165 | 439 | P>R | No | 1000Genomes | |
| ENSVATH06218164 | 439 | P>T | No | 1000Genomes | |
| ENSVATH06218166 | 440 | S>T | No | 1000Genomes | |
| tmp_3_16385837_C_T | 447 | T>I | No | 1000Genomes | |
| tmp_3_16385839_G_A | 448 | V>I | No | 1000Genomes | |
| ENSVATH00398725 | 470 | G>E | No | 1000Genomes | |
| tmp_3_16386043_G_A | 485 | A>T | No | 1000Genomes | |
| ENSVATH06218171 | 492 | T>R | No | 1000Genomes | |
| tmp_3_16386067_G_A | 493 | A>T | No | 1000Genomes | |
| ENSVATH12466925 | 495 | V>L | No | 1000Genomes | |
| ENSVATH12466926 | 507 | G>S | No | 1000Genomes | |
| ENSVATH14357630 | 508 | L>I | No | 1000Genomes | |
| ENSVATH02424718 | 511 | I>L | No | 1000Genomes | |
| ENSVATH02424718 | 511 | I>V | No | 1000Genomes | |
| ENSVATH02424719 | 518 | A>T | No | 1000Genomes | |
| ENSVATH12466927 | 520 | H>Y | No | 1000Genomes | |
| ENSVATH12466928 | 522 | Q>K | No | 1000Genomes |
No associated diseases with Q9FYC2
3 regional properties for Q9FYC2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Calreticulin/calnexin, conserved site | 108 - 123 | IPR018124-1 |
| conserved_site | Calreticulin/calnexin, conserved site | 140 - 148 | IPR018124-2 |
| conserved_site | Calreticulin/calnexin, conserved site | 253 - 265 | IPR018124-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.15.17 | With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. |
| chloroplast thylakoid | Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana. |
| chloroplast thylakoid membrane | The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2 iron, 2 sulfur cluster binding | Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| chlorophyllide a oxygenase [overall] activity | Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. |
| iron-sulfur cluster binding | Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| pheophorbide a oxygenase activity | Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell death | Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). |
| chlorophyll catabolic process | The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| flower development | The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. |
| fruit development | The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9MBA1 | CAO | Chlorophyllide a oxygenase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVVLLSSTS | ATITKSQSKK | IPFLSPTTKF | PLKVSISPSR | SKLFHNPLRV | AAPPSVPTSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STEEKRIEEE | YGGDKEEEGS | EFKWRDHWYP | VSLVEDLDPN | VPTPFQLLGR | DLVLWFDRND |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QKWAAFDDLC | PHRLAPLSEG | RLDENGHLQC | SYHGWSFGGC | GSCTRIPQAA | TSGPEARAVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPRACAIKFP | TMVSQGLLFV | WPDENGWDRA | NSIEPPRLPD | DFDKPEFSTV | TIQRDLFYGY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DTLMENVSDP | SHIDFAHHKV | TGRRDRAKPL | PFKVESSGPW | GFQGANDDSP | RITAKFVAPC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YSMNKIELDA | KLPIVGNQKW | VIWICSFNIP | MAPGKTRSIV | CSARNFFQFS | VPGPAWWQVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PRWYEHWTSN | LVYDGDMIVL | QGQEKVFLAK | SMESPDYDVN | KQYTKLTFTP | TQADRFVLAF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RNWLRRHGKS | QPEWFGSTPS | NQPLPSTVLT | KRQMLDRFDQ | HTQVCSSCKG | AYNSFQILKK |
| 490 | 500 | 510 | 520 | 530 | |
| FLVGATVFWA | ATAGVPSDVQ | IRLVLAGLSL | ISAASAYALH | EQEKNFVFRD | YVHSEIE |