AiPD: Autoinhibited Protein Database

Gene name	BETA-OHASE (2, B2, CHY2, At5g52570, F6N7.5)
Protein name	Beta-carotene 3-hydroxylase 2, chloroplastic
Names	AtB2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G52570
EC number	1.14.15.24: With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-118 (Predicted disordered autoinhibitory region) PR

1-118 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LTG0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_21336845_G_T	15	L>I	No	1000Genomes
ENSVATH07402678	18	S>F	No	1000Genomes
ENSVATH07402679	18	S>P	No	1000Genomes
ENSVATH07402675	28	T>A	No	1000Genomes
ENSVATH07402674	32	P>R	No	1000Genomes
ENSVATH03415315	34	S>F	No	1000Genomes
ENSVATH12720553	34	S>P	No	1000Genomes
ENSVATH07402671	45	I>T	No	1000Genomes
ENSVATH07402667	55	R>Q	No	1000Genomes
ENSVATH07402666	57	Q>E	No	1000Genomes
tmp_5_21336680_T_G	70	T>P	No	1000Genomes
ENSVATH00729657	72	S>N	No	1000Genomes
ENSVATH12720552	72	S>R	No	1000Genomes
ENSVATH00729656	79	T>A	No	1000Genomes
ENSVATH03415313	82	L>H	No	1000Genomes
ENSVATH07402663	89	K>E	No	1000Genomes
ENSVATH12720550	90	K>T	No	1000Genomes
ENSVATH14628288	112	I>T	No	1000Genomes
tmp_5_21336551_T_C	113	M>V	No	1000Genomes
ENSVATH12720546	131	L>V	No	1000Genomes
ENSVATH12720545	138	A>T	No	1000Genomes
tmp_5_21336036_C_A	151	A>S	No	1000Genomes
tmp_5_21335817_T_C	193	I>V	No	1000Genomes
ENSVATH03415298	201	L>F	No	1000Genomes
ENSVATH07402640	202	N>S	No	1000Genomes
ENSVATH07402639	205	L>F	No	1000Genomes
tmp_5_21335778_C_T	206	V>I	No	1000Genomes
ENSVATH00729648	243	N>D	No	1000Genomes
tmp_5_21335325_G_A	247	L>F	No	1000Genomes
ENSVATH03415273	267	Y>H	No	1000Genomes

Type	Name	Position	InterPro Accession
conserved_site	Sugar transporter, conserved site	141 - 157	IPR005829
domain	Major facilitator superfamily domain	83 - 498	IPR020846

		Description
EC Number	1.14.15.24	With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Plastid, chloroplast membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast membrane	Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
iron ion binding	Binding to an iron (Fe) ion.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Name	Definition
xanthophyll biosynthetic process	The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O49814	CA2	Beta-carotene hydroxylase 2, chloroplastic	Capsicum annuum (Capsicum pepper)	PR
Q9SZZ8	BETA-OHASE	Beta-carotene 3-hydroxylase 1, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR