Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9LSZ0

Entry ID Method Resolution Chain Position Source
AF-Q9LSZ0-F1 Predicted AlphaFoldDB

43 variants for Q9LSZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_7663620_T_G 7 K>Q No 1000Genomes
ENSVATH10836281 8 L>V No 1000Genomes
ENSVATH10836280 11 K>N No 1000Genomes
ENSVATH10836278 17 R>G No 1000Genomes
ENSVATH10836277 24 S>P No 1000Genomes
ENSVATH10836276 27 N>T No 1000Genomes
tmp_3_7663552_T_A 29 K>N No 1000Genomes
ENSVATH05880397 32 L>F No 1000Genomes
ENSVATH05880396 41 M>L No 1000Genomes
ENSVATH13962229 60 P>S No 1000Genomes
tmp_3_7663454_G_C 62 A>G No 1000Genomes
tmp_3_7663449_C_T 64 E>K No 1000Genomes
tmp_3_7663439_A_G 67 I>T No 1000Genomes
ENSVATH10836224 73 I>T No 1000Genomes
ENSVATH10836223 77 A>T No 1000Genomes
tmp_3_7663392_A_G 83 F>L No 1000Genomes
ENSVATH05880392 94 V>L No 1000Genomes
tmp_3_7663251_A_G 102 L>S No 1000Genomes
tmp_3_7663206_A_C 117 L>R No 1000Genomes
tmp_3_7663192_G_T 122 P>T No 1000Genomes
ENSVATH02174841 125 I>R No 1000Genomes
ENSVATH10836222 125 I>V No 1000Genomes
tmp_3_7663159_C_T 133 E>K No 1000Genomes
tmp_3_7663134_G_C 141 S>C No 1000Genomes
tmp_3_7663081_T_G 159 I>L No 1000Genomes
ENSVATH05880391 169 I>L No 1000Genomes
ENSVATH10836221 181 H>Y No 1000Genomes
ENSVATH02174840 182 D>N No 1000Genomes
tmp_3_7662981_C_A 192 R>M No 1000Genomes
ENSVATH05880388 198 D>G No 1000Genomes
tmp_3_7662910_C_T 216 G>S No 1000Genomes
ENSVATH05880387 231 R>L No 1000Genomes
ENSVATH05880387 231 R>Q No 1000Genomes
tmp_3_7662790_G_C,A 256 R>C No 1000Genomes
tmp_3_7662790_G_C,A 256 R>G No 1000Genomes
ENSVATH13962227 265 G>S No 1000Genomes
ENSVATH00338716 267 N>D No 1000Genomes
ENSVATH05880386 278 R>Q No 1000Genomes
tmp_3_7662679_A_G 293 Y>H No 1000Genomes
tmp_3_7662652_T_C 302 S>G No 1000Genomes
ENSVATH00338714 313 V>L No 1000Genomes
ENSVATH05880385 325 S>P No 1000Genomes
tmp_3_7662577_A_T 327 S>T No 1000Genomes

No associated diseases with Q9LSZ0

6 regional properties for Q9LSZ0

Type Name Position InterPro Accession
domain Activin types I and II receptor domain 26 - 95 IPR000472
domain Protein kinase domain 195 - 487 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 196 - 478 IPR001245
domain GS domain 165 - 195 IPR003605
active_site Serine/threonine-protein kinase, active site 319 - 331 IPR008271
binding_site Protein kinase, ATP binding site 201 - 222 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41567 EIF1 Eukaryotic translation initiation factor 1 Homo sapiens (Human) PR
P48024 Eif1 Eukaryotic translation initiation factor 1 Mus musculus (Mouse) PR
Q9XIR4 APO1 APO protein 1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSNWRHKLWR KLSSFQRASY STTSSRNNKL KLDDLRKLRP MILKRIENRA KDYPVKEIVP
70 80 90 100 110 120
VAEEILIARK NLISNIAALL KVFPVLTCKF CSEVFVGKEG HLIETCRSYI RRGNNRLHEW
130 140 150 160 170 180
VPGSINDILV PVESYHLHNI SQGVIRHQER FDYDRVPAIL ELCCQAGAIH PEEILQYSEI
190 200 210 220 230 240
HDNPQISEED IRSLPAGDLK YVGANALMAW EKVRAGVKKL LLVYPSKVCK RCKEVHVGPS
250 260 270 280 290 300
GHKARLCGVF KYESWRGTHY WEKAGVNDLV PEKMVWHRRP QDPVVLVDEG RSYYGHAPAI
310 320 330
VSLCSHTGAI VPVKYACKMK PQGLSFSFTN PVPNLET