P48024

PR
Gene name
Eif1 (Sui1, Sui1-rs1)
Protein name
Eukaryotic translation initiation factor 1
Names
Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, eIF1, Protein translation factor SUI1 homolog
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20918
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48024

Entry ID Method Resolution Chain Position Source
AF-P48024-F1 Predicted AlphaFoldDB

2 variants for P48024

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389200107 104 K>M No EVA
rs3389196338 113 F>L No EVA

No associated diseases with P48024

1 regional properties for P48024

Type Name Position InterPro Accession
conserved_site Actin/actin-like conserved site 149 - 161 IPR020902

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ribosomal small subunit binding Binding to a small ribosomal subunit.
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
dosage compensation by inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.
regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41567 EIF1 Eukaryotic translation initiation factor 1 Homo sapiens (Human) PR
Q9LSZ0 APO4 APO protein 4, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIR4 APO1 APO protein 1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
70 80 90 100 110
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLIEI GLAKDDQLKV HGF