P41567

PR
Gene name
EIF1 (SUI1)
Protein name
Eukaryotic translation initiation factor 1
Names
eIF1, A121, Protein translation factor SUI1 homolog, Sui1iso1
Species
Homo sapiens (Human)
KEGG Pathway
hsa:10209
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for P41567

Entry ID Method Resolution Chain Position Source
2IF1 NMR - A 1-113 PDB
4KZX X-ray 781 A l 1-113 PDB
4KZY X-ray 701 A l 1-113 PDB
6YBW EM 310 A p 1-113 PDB
6ZMW EM 370 A p 1-113 PDB
6ZP4 EM 290 A Z 1-113 PDB
6ZVJ EM 380 A N 23-113 PDB
7A09 EM 350 A Z 1-113 PDB
7QP6 EM 470 A p 1-113 PDB
8PPK EM 298 A p 1-113 PDB
8PPL EM 265 A Ip 1-113 PDB
AF-P41567-F1 Predicted AlphaFoldDB

50 variants for P41567

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1329636873
CA399486921
 6 N>S No ClinGen
TOPMed
gnomAD
CA399486943
rs1567766158
 7 L>F No ClinGen
Ensembl
CA8563922
rs766705600
 9 S>F No ClinGen
ExAC
gnomAD
CA399486998
rs1441863765
 10 F>V No ClinGen
TOPMed
CA399487023
rs1200585423
 11 D>N No ClinGen
gnomAD
TCGA novel 12 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA8563958
rs748378272
 14 A>V No ClinGen
ExAC
TOPMed
CA399488376
rs1290137210
 20 D>N No ClinGen
gnomAD
rs1002623230
CA399488391
 21 D>E No ClinGen
gnomAD
TCGA novel 21 D>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1281929196
CA399488408
 24 P>L No ClinGen
TOPMed
rs1281929196
CA399488407
 24 P>R No ClinGen
TOPMed
CA290695568
rs778774928
 25 A>S No ClinGen
Ensembl
CA8563959
rs772205834
 25 A>V No ClinGen
ExAC
gnomAD
rs773595308
CA290695572
 26 G>A No ClinGen
Ensembl
TCGA novel 26 G>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs760745427
CA8563961
 27 T>I No ClinGen
ExAC
TOPMed
gnomAD
CA8563963
rs777106913
 28 E>D No ClinGen
ExAC
gnomAD
rs771365370
CA8563962
 28 E>Q No ClinGen
ExAC
gnomAD
rs765615616
CA8563965
 33 I>V No ClinGen
ExAC
gnomAD
CA290695603
rs4911
 36 Q>K No ClinGen
Ensembl
TCGA novel 40 G>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA290695627
rs11550324
 41 R>K No ClinGen
Ensembl
rs1308187782
CA399488526
 42 K>E No ClinGen
gnomAD
rs1597718365
CA399488537
 43 T>N No ClinGen
Ensembl
rs1349353489
CA399488550
 45 T>I No ClinGen
gnomAD
rs1218411070
CA399488554
 46 T>A No ClinGen
gnomAD
TCGA novel 57 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA290695657
rs1141310
 57 K>R No ClinGen
Ensembl
VAR_052505
rs3390
CA290695669
 59 L>P No ClinGen
UniProt
Ensembl
dbSNP
rs1264037897
CA399488655
 60 V>L No ClinGen
gnomAD
TCGA novel 68 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA399488759
rs1301636424
 73 V>I No ClinGen
gnomAD
rs767112766
CA8563994
 74 I>V No ClinGen
ExAC
gnomAD
rs1320286011
CA399488795
 78 E>K No ClinGen
gnomAD
TCGA novel 80 G>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs3387
CA290695921
VAR_052506
 90 R>G No ClinGen
UniProt
Ensembl
dbSNP
rs756038029
CA8563996
 91 K>R No ClinGen
ExAC
TOPMed
gnomAD
CA8563998
rs753608806
 94 C>R No ClinGen
ExAC
TOPMed
gnomAD
CA399488940
rs1567766790
 98 V>I No ClinGen
Ensembl
rs931075058
CA290695950
 99 E>G No ClinGen
Ensembl
rs748527284
CA8564030
 100 I>T No ClinGen
ExAC
gnomAD
CA8564029
rs774814551
 100 I>V No ClinGen
ExAC
TOPMed
gnomAD
CA290696508
rs1804483
 102 L>P No ClinGen
Ensembl
CA8564032
rs772722219
 103 A>T No ClinGen
ExAC
gnomAD
CA8564033
rs760439466
 104 K>R No ClinGen
ExAC
gnomAD
rs1474052133
CA399489043
 106 D>N No ClinGen
gnomAD
TCGA novel 108 L>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs3391
CA290696524
 110 V>I No ClinGen
Ensembl
CA399489096
rs1597718812
 113 F>V No ClinGen
Ensembl

No associated diseases with P41567

1 regional properties for P41567

Type Name Position InterPro Accession
domain SUI1 domain 29 - 101 IPR001950

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ribosomal small subunit binding Binding to a small ribosomal subunit.
RNA binding Binding to an RNA molecule or a portion thereof.
translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P48024 Eif1 Eukaryotic translation initiation factor 1 Mus musculus (Mouse) PR
Q9LSZ0 APO4 APO protein 4, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIR4 APO1 APO protein 1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
70 80 90 100 110
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLVEI GLAKDDQLKV HGF