Q9LE59
Gene name |
GAUT1 (JS36, LGT1, At3g61130, T20K12.30) |
Protein name |
Polygalacturonate 4-alpha-galacturonosyltransferase |
Names |
Alpha-1,4-galacturonosyltransferase 1, Galacturonosyltransferase 1, Like glycosyl transferase 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G61130 |
EC number |
2.4.1.43: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LE59
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LE59-F1 | Predicted | AlphaFoldDB |
32 variants for Q9LE59
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_22622426_G_T | 10 | V>F | No | 1000Genomes | |
| ENSVATH06353434 | 15 | G>A | No | 1000Genomes | |
| ENSVATH06353435 | 25 | V>G | No | 1000Genomes | |
| tmp_3_22622886_T_A | 54 | I>N | No | 1000Genomes | |
| tmp_3_22623174_G_A | 87 | S>N | No | 1000Genomes | |
| ENSVATH00430430 | 124 | A>T | No | 1000Genomes | |
| ENSVATH12865241 | 142 | K>I | No | 1000Genomes | |
| ENSVATH12865242 | 145 | I>V | No | 1000Genomes | |
| ENSVATH06353460 | 163 | K>R | No | 1000Genomes | |
| ENSVATH00430435 | 189 | E>A | No | 1000Genomes | |
| tmp_3_22623834_T_G | 214 | S>A | No | 1000Genomes | |
| ENSVATH06353462 | 253 | D>E | No | 1000Genomes | |
| tmp_3_22623951_G_C | 253 | D>H | No | 1000Genomes | |
| tmp_3_22623984_G_A | 264 | D>N | No | 1000Genomes | |
| tmp_3_22624111_C_A | 275 | L>I | No | 1000Genomes | |
| ENSVATH14464274 | 277 | A>T | No | 1000Genomes | |
| tmp_3_22624205_C_G | 306 | A>G | No | 1000Genomes | |
| ENSVATH06353467 | 312 | S>N | No | 1000Genomes | |
| ENSVATH02533238 | 313 | L>S | No | 1000Genomes | |
| ENSVATH00430443 | 345 | L>F | No | 1000Genomes | |
| ENSVATH00430443 | 345 | L>I | No | 1000Genomes | |
| ENSVATH06353468 | 348 | P>S | No | 1000Genomes | |
| ENSVATH00430444 | 351 | R>K | No | 1000Genomes | |
| ENSVATH12865267 | 448 | A>T | No | 1000Genomes | |
| ENSVATH12865268 | 542 | P>T | No | 1000Genomes | |
| ENSVATH14464297 | 547 | N>K | No | 1000Genomes | |
| tmp_3_22625044_A_T | 549 | N>I | No | 1000Genomes | |
| ENSVATH14464299 | 569 | K>T | No | 1000Genomes | |
| ENSVATH06353475 | 575 | I>M | No | 1000Genomes | |
| ENSVATH12865269 | 581 | N>T | No | 1000Genomes | |
| ENSVATH14464300 | 663 | H>P | No | 1000Genomes | |
| ENSVATH14464301 | 664 | P>Q | No | 1000Genomes |
No associated diseases with Q9LE59
No regional properties for Q9LE59
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9LE59 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.43 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi medial cisterna | The middle Golgi cisterna (or cisternae). |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| polygalacturonate 4-alpha-galacturonosyltransferase activity | Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| homogalacturonan biosynthetic process | The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H1C3 | GLT8D2 | Glycosyltransferase 8 domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q9FH36 | GAUT12 | Probable galacturonosyltransferase 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FWY9 | GATL5 | Probable galacturonosyltransferase-like 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALKRGLSGV | NRIRGSGGGS | RSVLVLLIFF | CVFAPLCFFV | GRGVYIDSSN | DYSIVSVKQN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDWRERLAMQ | SVRSLFSKEI | LDVIATSTAD | LGPLSLDSFK | KNNLSASWRG | TGVDPSFRHS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENPATPDVKS | NNLNEKRDSI | SKDSIHQKVE | TPTKIHRRQL | REKRREMRAN | ELVQHNDDTI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKLENAAIER | SKSVDSAVLG | KYSIWRRENE | NDNSDSNIRL | MRDQVIMARV | YSGIAKLKNK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NDLLQELQAR | LKDSQRVLGE | ATSDADLPRS | AHEKLRAMGQ | VLAKAKMQLY | DCKLVTGKLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AMLQTADEQV | RSLKKQSTFL | AQLAAKTIPN | PIHCLSMRLT | IDYYLLSPEK | RKFPRSENLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NPNLYHYALF | SDNVLAASVV | VNSTIMNAKD | PSKHVFHLVT | DKLNFGAMNM | WFLLNPPGKA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIHVENVDEF | KWLNSSYCPV | LRQLESAAMR | EYYFKADHPT | SGSSNLKYRN | PKYLSMLNHL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFYLPEVYPK | LNKILFLDDD | IIVQKDLTPL | WEVNLNGKVN | GAVETCGESF | HRFDKYLNFS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NPHIARNFNP | NACGWAYGMN | MFDLKEWKKR | DITGIYHKWQ | NMNENRTLWK | LGTLPPGLIT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FYGLTHPLNK | AWHVLGLGYN | PSIDKKDIEN | AAVVHYNGNM | KPWLELAMSK | YRPYWTKYIK |
| 670 | |||||
| FDHPYLRRCN | LHE |