Q9LD55
PR
Gene name |
TIF3A1 (At4g11420, F25E4.40) |
Protein name |
Eukaryotic translation initiation factor 3 subunit A |
Names |
eIF3a, Eukaryotic translation initiation factor 3 large subunit, Eukaryotic translation initiation factor 3 subunit 10, eIF-3-theta, p114 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G11420 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LD55
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LD55-F1 | Predicted | AlphaFoldDB |
48 variants for Q9LD55
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_6951175_G_C | 229 | L>V | No | 1000Genomes | |
| tmp_4_6951144_T_C | 239 | K>R | No | 1000Genomes | |
| ENSVATH14136986 | 288 | S>F | No | 1000Genomes | |
| tmp_4_6950848_A_C | 293 | H>Q | No | 1000Genomes | |
| tmp_4_6950361_G_A | 397 | L>F | No | 1000Genomes | |
| ENSVATH06618500 | 415 | Q>R | No | 1000Genomes | |
| tmp_4_6950238_G_T | 438 | Q>K | No | 1000Genomes | |
| tmp_4_6950232_A_C | 440 | S>A | No | 1000Genomes | |
| ENSVATH11507819 | 461 | I>T | No | 1000Genomes | |
| ENSVATH11507817 | 474 | V>I | No | 1000Genomes | |
| tmp_4_6950002_T_C | 478 | Q>R | No | 1000Genomes | |
| tmp_4_6949966_A_C | 490 | V>G | No | 1000Genomes | |
| tmp_4_6949929_C_T | 502 | M>I | No | 1000Genomes | |
| tmp_4_6949916_T_A | 507 | I>F | No | 1000Genomes | |
| tmp_4_6949915_A_G | 507 | I>T | No | 1000Genomes | |
| tmp_4_6949761_C_T | 520 | D>N | No | 1000Genomes | |
| ENSVATH06618491 | 529 | L>S | No | 1000Genomes | |
| ENSVATH14136960 | 550 | I>M | No | 1000Genomes | |
| tmp_4_6949665_T_A | 552 | N>Y | No | 1000Genomes | |
| tmp_4_6949449_G_A | 594 | L>F | No | 1000Genomes | |
| ENSVATH06618486 | 677 | M>L | No | 1000Genomes | |
| tmp_4_6949098_G_A | 684 | L>F | No | 1000Genomes | |
| ENSVATH14136957 | 702 | L>M | No | 1000Genomes | |
| ENSVATH00490820 | 717 | F>L | No | 1000Genomes | |
| tmp_4_6948850_A_T | 737 | L>M | No | 1000Genomes | |
| tmp_4_6948819_A_G | 747 | L>S | No | 1000Genomes | |
| ENSVATH00490819 | 748 | G>D | No | 1000Genomes | |
| ENSVATH11507776 | 749 | N>Y | No | 1000Genomes | |
| ENSVATH11507733 | 781 | R>Q | No | 1000Genomes | |
| tmp_4_6948490_T_A | 805 | R>W | No | 1000Genomes | |
| tmp_4_6948337_T_C | 821 | R>G | No | 1000Genomes | |
| ENSVATH11507730 | 836 | A>T | No | 1000Genomes | |
| ENSVATH00490814 | 836 | A>V | No | 1000Genomes | |
| tmp_4_6948207_G_A | 864 | A>V | No | 1000Genomes | |
| ENSVATH06618473 | 868 | R>C | No | 1000Genomes | |
| ENSVATH06618472 | 873 | T>I | No | 1000Genomes | |
| ENSVATH08327636 | 883 | A>T | No | 1000Genomes | |
| ENSVATH11507728 | 883 | A>V | No | 1000Genomes | |
| ENSVATH14136934 | 904 | T>I | No | 1000Genomes | |
| tmp_4_6948080_C_G | 906 | E>D | No | 1000Genomes | |
| ENSVATH06618470 | 909 | G>A | No | 1000Genomes | |
| tmp_4_6948057_G_A | 914 | T>I | No | 1000Genomes | |
| ENSVATH06618469 | 924 | R>H | No | 1000Genomes | |
| ENSVATH00490813 | 926 | P>L | No | 1000Genomes | |
| ENSVATH02788447 | 929 | G>V | No | 1000Genomes | |
| tmp_4_6948004_G_T | 932 | H>N | No | 1000Genomes | |
| tmp_4_6947983_C_T | 939 | A>T | No | 1000Genomes | |
| tmp_4_6947838_C_A | 987 | R>L | No | 1000Genomes |
No associated diseases with Q9LD55
1 regional properties for Q9LD55
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | SsrA-binding protein, conserved site | 31 - 43 | IPR020081 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic 43S preinitiation complex | A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| eukaryotic translation initiation factor 3 complex, eIF3e | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. |
| eukaryotic translation initiation factor 3 complex, eIF3m | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. |
| multi-eIF complex | A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| formation of cytoplasmic translation initiation complex | Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
| translation reinitiation | A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38249 | RPG1 | Eukaryotic translation initiation factor 3 subunit A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | Homo sapiens (Human) | PR |
| Q9XHR2 | TIF3A1 | Eukaryotic translation initiation factor 3 subunit A | Zea mays (Maize) | PR |
| P23116 | Eif3a | Eukaryotic translation initiation factor 3 subunit A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANFAKPENA | LKRADELINV | GQKQDALQAL | HDLITSKRYR | AWQKPLEKIM | FKYLDLCVDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRGRFAKDGL | IQYRIVCQQV | NVSSLEEVIK | HFLHLATDKA | EQARSQADAL | EEALDVDDLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADRKPEDLQL | SIVSGEKGKD | RSDRELVTPW | FKFLWETYRT | VLEILRNNSK | LEALYAMTAH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KAFQFCKQYK | RTTEFRRLCE | IIRNHLANLN | KYRDQRDRPD | LSAPESLQLY | LDTRFDQLKV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ATELGLWQEA | FRSVEDIYGL | MCMVKKTPKS | SLLMVYYSKL | TEIFWISSSH | LYHAYAWFKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSLQKNFNKN | LSQKDLQLIA | SSVVLAALSI | PPFDRAQSAS | HMELENEKER | NLRMANLIGF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLEPKFEGKD | MLSRSALLSE | LVSKGVLSCA | SQEVKDLFHV | LEHEFHPLDL | GSKIQPLLEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ISKSGGKLSS | APSLPEVQLS | QYVPSLEKLA | TLRLLQQVSK | IYQTIRIESL | SQLVPFFQFS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EVEKISVDAV | KNNFVAMKVD | HMKGVVIFGN | LGIESDGLRD | HLAVFAESLS | KVRAMLYPVP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SKASKLAGVI | PNLADTVEKE | HKRLLARKSI | IEKRKEDQER | QQLEMEREEE | QKRLKLQKLT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EEAEQKRLAA | ELAERRKQRI | LREIEEKELE | EAQALLEETE | KRMKKGKKKP | LLDGEKVTKQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SVKERALTEQ | LKERQEMEKK | LQKLAKTMDY | LERAKREEAA | PLIEAAYQRR | LVEEREFYER |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EQQREVELSK | ERHESDLKEK | NRLSRMLGNK | EIFQAQVISR | RQAEFDRIRT | EREERISKII |
| 790 | 800 | 810 | 820 | 830 | 840 |
| REKKQERDIK | RKQIYYLKIE | EERIRKLQEE | EEARKQEEAE | RLKKVEAERK | ANLDKAFEKQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RQREIELEEK | SRREREELLR | GTNAPPARLA | EPTVTPVGTT | APAAAAAAAG | APAAPYVPKW |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KRQTTEVSGP | SAPTSSETDR | RSNRGPPPGD | DHWGSNRGAA | QNTDRWTSNR | ERSGPPAEGG |
| 970 | 980 | ||||
| DRWGSGPRGS | DDRRSTFGSS | RPRPTQR |