P23116
PR
Gene name |
Eif3a (Csma, Eif3, Eif3s10) |
Protein name |
Eukaryotic translation initiation factor 3 subunit A |
Names |
eIF3a, Centrosomin, Eukaryotic translation initiation factor 3 subunit 10, eIF-3-theta, eIF3 p167, eIF3 p180, eIF3 p185, p162 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13669 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P23116
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P23116-F1 | Predicted | AlphaFoldDB |
40 variants for P23116
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3409270680 | 4 | Y>S | No | EVA | |
| rs3389458127 | 138 | Q>H | No | EVA | |
| rs3389566057 | 172 | R>H | No | EVA | |
| rs3389529273 | 175 | H>L | No | EVA | |
| rs3389549173 | 189 | T>I | No | EVA | |
| rs3389506353 | 212 | H>D | No | EVA | |
| rs3389543670 | 221 | N>K | No | EVA | |
| rs3389549107 | 232 | T>N | No | EVA | |
| rs3389458084 | 243 | M>L | No | EVA | |
| rs3411748321 | 245 | L>* | No | EVA | |
| rs3389458099 | 380 | L>I | No | EVA | |
| rs3413058813 | 397 | E>K | No | EVA | |
| rs3411152957 | 432 | Q>H | No | EVA | |
| rs3389545265 | 442 | Q>* | No | EVA | |
| rs234673126 | 507 | V>I | No | EVA | |
| rs48187008 | 514 | M>K | No | EVA | |
| rs260526781 | 538 | R>K | No | EVA | |
| rs13475271 | 545 | E>* | No | EVA | |
| rs3389549180 | 559 | K>* | No | EVA | |
| rs3389543605 | 573 | Q>* | No | EVA | |
| rs3389497932 | 574 | T>R | No | EVA | |
| rs3389497977 | 576 | E>G | No | EVA | |
| rs3408382272 | 602 | Q>K | No | EVA | |
| rs3389516243 | 603 | K>R | No | EVA | |
| rs3389565975 | 606 | K>E | No | EVA | |
| rs3389543597 | 636 | V>D | No | EVA | |
| rs3389550124 | 762 | M>I | No | EVA | |
| rs3389562081 | 806 | Y>H | No | EVA | |
| rs3389559840 | 815 | Q>* | No | EVA | |
| rs3389561995 | 816 | R>G | No | EVA | |
| rs3389543594 | 817 | R>W | No | EVA | |
| rs3389550117 | 826 | R>Q | No | EVA | |
| rs3389566040 | 847 | R>* | No | EVA | |
| rs3389543654 | 885 | R>T | No | EVA | |
| rs3389529196 | 1011 | H>Q | No | EVA | |
| rs3389529219 | 1084 | D>E | No | EVA | |
| rs3389544981 | 1110 | W>* | No | EVA | |
| rs252389008 | 1118 | V>I | No | EVA | |
| rs3389544990 | 1126 | R>I | No | EVA | |
| rs265876353 | 1239 | D>E | No | EVA |
No associated diseases with P23116
1 regional properties for P23116
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Proteasome component (PCI) domain | 315 - 506 | IPR000717 |
Functions
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic 43S preinitiation complex | A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| eukaryotic translation initiation factor 3 complex, eIF3e | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. |
| eukaryotic translation initiation factor 3 complex, eIF3m | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| multi-eIF complex | A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| receptor tyrosine kinase binding | Binding to a receptor that possesses protein tyrosine kinase activity. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| formation of cytoplasmic translation initiation complex | Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
| IRES-dependent viral translational initiation | Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. |
| negative regulation of ERK1 and ERK2 cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| translation reinitiation | A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon. |
| viral translational termination-reinitiation | A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38249 | RPG1 | Eukaryotic translation initiation factor 3 subunit A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | Homo sapiens (Human) | PR |
| Q9XHR2 | TIF3A1 | Eukaryotic translation initiation factor 3 subunit A | Zea mays (Maize) | PR |
| Q9LD55 | TIF3A1 | Eukaryotic translation initiation factor 3 subunit A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPAYFQRPEN | ALKRANEFLE | VGKKQPALDV | LYDVMKSKKH | RTWQKIHEPI | MLKYLELCVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRKSHLAKEG | LYQYKNICQQ | VNIKSLEDVV | RAYLKLAEEK | TEAAKEESQQ | MVLDIEDLDN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQTPESVLLS | AVSGEDTQDR | TDRLLLTPWV | KFLWESYRQC | LDLLRNNSRV | ERLYHDIAQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AFKFCLQYTR | KAEFRKLCDN | LRMHLSQIQR | HHNQSTAINL | NNPESQSMHL | ETRLVQLDSA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISMELWQEAF | KAVEDIHGLF | SLSKKPPKPQ | LMANYYNKVS | TVFWKSGNAL | FHASTLHRLY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HLSREMRKNL | TQEEMQRMST | RVLLATLSIP | ITPERTDIAR | LLDMDGIIVE | KQRRLATLLG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQAPPTRIGL | INDMVRFSVL | QYVVPEVKDL | YNWLEVEFNP | LKLCERVTKV | LNWVREQPEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EPELQQYVPQ | LQNNTILRLL | QQVAQIYQSI | EFSRLTSLVP | FVDAFQLERA | IVDAARHCDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QVRIDHTSRT | LSFGSDLNYA | TREDAPVGPH | LQSMPSEQIR | NQLTAMSSVL | AKALEVIRPA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HILQEKEEQH | QLAVNAYLKN | SRKEHQRILA | RRQTIEERKE | RLESLNIQRE | KEELEQREAE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQKVRKAEEE | RLRQEAKERE | KERILQEHEQ | IKKKTVRERL | EQIKKTELGA | KAFKDIDIED |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LEELDPDFIM | AKQVEQLEKE | KKELQERLKN | QEKKIDYFER | AKRLEEIPLI | KSAYEEQRVK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DMDLWEQQEE | ERITTMQLER | EKALEHKNRM | SRMLEDRDLF | VMRLKAARQS | VYEEKLKQFE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ERLAEERHSR | LEDRKRQRKE | ERKITYYREK | EEEEQRRAEE | QMLKEREERE | RAERAKREEE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LREYQERVKK | LEEVERKKRQ | RELEIEERER | RREEERRLGD | DPLSRKDSRW | GDRDSEGTWR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KGPEADSEWR | RGPPEKEWRR | ETRDDERPHR | RDEDRLRRLG | GDDEERESSL | RPDDDRIPRR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GLDDDRGPRR | GPDEDRFSRR | GTDDDRPSWR | NADDDRPPRR | IGDDDRGSWR | HTDDDRPPRR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GLDDERGSWR | TADEDRGPRR | GMDDDRGPRR | GGADDERSSW | RNADDDRGPR | RGMDDDRGPR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RGLDDDRGPW | RNAAEDRISR | RGADDDRGPW | RNMDDDRVPR | RGDDARPGPW | RPFVKPGGWR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| EKEKAREESW | GPPRESRPSE | EREWDRDKEK | DRDNQDREEN | DKDLERDRDR | ERDGDREDRF |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| RRPRDEGGWR | RGPAEESSSW | RDSSRRDDRD | REDRRRDRDD | RRDLRDLRDR | RDLRDDRDRR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GPPLRSEREE | ASSWRRTDDR | KDDRTEERDP | PRRVPPPALS | RDRERERERE | GEKEKASWRA |
| 1330 | 1340 | ||||
| EKDRESLRRT | KNETDEDGWT | TVRR |