AiPD: Autoinhibited Protein Database

Q14152

Gene name	EIF3A
Protein name	Eukaryotic translation initiation factor 3 subunit A
Names	eIF3a, Eukaryotic translation initiation factor 3 subunit 10, eIF-3-theta, eIF3 p167, eIF3 p180, eIF3 p185
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8661
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

845-932 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

845-932 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

14 structures for Q14152

Entry ID	Method	Resolution	Chain	Position	Source
3J8B	EM	-	A	1-494	PDB
3J8C	EM	-	A	1-494	PDB
6YBD	EM	330 A	u	1-1382	PDB
6YBT	EM	600 A	u	33-1382	PDB
6ZMW	EM	370 A	u	1-1382	PDB
6ZON	EM	300 A	A	1-601	PDB
6ZP4	EM	290 A	A	1-1382	PDB
6ZVJ	EM	380 A	A	4-725	PDB
7A09	EM	350 A	A	1-1382	PDB
7QP6	EM	470 A	u	1-1382	PDB
7QP7	EM	370 A	u	1-1382	PDB
8OZ0	EM	350 A	A	1-1382	PDB
8PPL	EM	265 A	Iu	1-1382	PDB
AF-Q14152-F1	Predicted				AlphaFoldDB

923 variants for Q14152

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA214173655 rs868376985	3	A>T		No	ClinGen gnomAD
rs758355282 CA5713944	3	A>V		No	ClinGen ExAC gnomAD
rs1310674203 CA378290612	8	P>S		No	ClinGen TOPMed gnomAD
rs1310674203 CA378290613	8	P>T		No	ClinGen TOPMed gnomAD
CA378290508 rs1312170235	14	R>H		No	ClinGen gnomAD
CA214173600 rs879136390	15	A>V		No	ClinGen Ensembl
CA214173599 rs953799485	17	E>Q		No	ClinGen TOPMed
TCGA novel	18	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378288098 rs1203836596	19	L>I		No	ClinGen gnomAD
rs867685192 CA214165964	22	G>D		No	ClinGen Ensembl
CA214165959 rs905376695	24	K>Q		No	ClinGen Ensembl
TCGA novel	25	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378287963 rs1456760727	30	V>I		No	ClinGen TOPMed
TCGA novel	31	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751940205 CA5713914	32	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA378287947 rs751940205	32	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA5713913 rs764414930	38	K>R		No	ClinGen ExAC gnomAD
TCGA novel	45	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378287696 rs1381223131	48	E>G		No	ClinGen gnomAD
CA378287704 rs1295812845	48	E>K		No	ClinGen gnomAD
CA5713911 rs776056546	49	P>A		No	ClinGen ExAC gnomAD
rs1428372791 CA378287549	59	V>M		No	ClinGen gnomAD
rs1013759865 CA214165882	60	D>E		No	ClinGen Ensembl
TCGA novel	61	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA214165871 rs575800176	62	R>H		No	ClinGen 1000Genomes gnomAD
rs892218354 CA214165867	63	K>R		No	ClinGen Ensembl
rs1426132886 CA378287476	64	S>T		No	ClinGen gnomAD
CA5713907 rs770731243	67	A>T		No	ClinGen ExAC
TCGA novel	68	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	68	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	69	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA214165863 rs267602388	70	G>R		No	ClinGen Ensembl
TCGA novel	71	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777749675 CA5713905	76	N>S		No	ClinGen ExAC gnomAD
rs776807662 CA214165842	77	I>V		No	ClinGen Ensembl
TCGA novel	84	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713873 rs758492981	88	D>V		No	ClinGen ExAC gnomAD
rs765480516 CA5713871	90	V>A		No	ClinGen ExAC gnomAD
rs185929392 CA5713870	96	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766042926 CA5713868	99	E>*		No	ClinGen ExAC gnomAD
rs772781682 CA5713867	99	E>G		No	ClinGen ExAC gnomAD
rs772781682 CA5713866	99	E>V		No	ClinGen ExAC gnomAD
rs892249524 CA214165463	105	K>E		No	ClinGen gnomAD
CA378286703 rs1179861261	109	Q>H		No	ClinGen gnomAD
rs1231548427 CA378286662	111	M>I		No	ClinGen gnomAD
CA378286674 rs1441887078	111	M>L		No	ClinGen gnomAD
CA5713864 rs761319152	112	V>I		No	ClinGen ExAC gnomAD
rs868631352 CA214165449	114	D>N		No	ClinGen gnomAD
rs1451818237 CA378286598	115	I>T		No	ClinGen gnomAD
TCGA novel	119	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378286507 rs1358158637	120	N>D		No	ClinGen TOPMed gnomAD
CA378286417 COSM465336 rs1299009750	124	P>L	kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA378286277 rs953652867	127	V>F		No	ClinGen TOPMed gnomAD
CA214165135 rs953652867	127	V>I		No	ClinGen TOPMed gnomAD
CA214165120 rs929870787	128	L>I		No	ClinGen gnomAD
TCGA novel	129	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378285461 rs1173745561	131	A>G		No	ClinGen gnomAD
CA378285457 rs1173745561	131	A>V		No	ClinGen gnomAD
rs1479911111 CA378285451	132	V>I		No	ClinGen gnomAD
rs1195191818 CA378285376	137	T>A		No	ClinGen gnomAD
CA378285369 rs1176544461	137	T>S		No	ClinGen gnomAD
rs1241413917 CA378285309	141	T>A		No	ClinGen gnomAD
TCGA novel	143	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261037126 CA378285136	153	L>M		No	ClinGen gnomAD
CA5713840 rs762744395	161	L>S		No	ClinGen ExAC TOPMed gnomAD
CA378285033 rs1471314610	163	L>V		No	ClinGen TOPMed
TCGA novel	164	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1359995703 CA378285002	167	N>S		No	ClinGen gnomAD
rs769746367 CA5713838	169	R>G		No	ClinGen ExAC gnomAD
TCGA novel	169	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1192479957 CA378284991	169	R>K		No	ClinGen TOPMed
rs1408676010 CA378284972	172	R>C		No	ClinGen gnomAD
rs942122392 CA214165042 COSM1346102	172	R>H	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA5713837 rs745767039	173	L>P		No	ClinGen ExAC gnomAD
CA5713835 rs746358454	177	I>M		No	ClinGen ExAC gnomAD
rs773321968 CA5713836	177	I>T		No	ClinGen ExAC gnomAD
rs760766102 CA214163129	181	A>G		No	ClinGen TOPMed
CA5713817 rs764986538	186	L>F		No	ClinGen ExAC TOPMed gnomAD
CA5713816 rs759521093	187	Q>R		No	ClinGen ExAC gnomAD
CA378284851 rs1257163017	188	Y>H		No	ClinGen TOPMed gnomAD
rs1470372936 CA378284840	189	T>A		No	ClinGen TOPMed
rs182093925 CA5713815 COSM915334	189	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5713813 rs761801638	190	R>H		No	ClinGen ExAC gnomAD
CA214163109 rs201828136	195	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5713811 rs769021856	200	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1390093037 CA378284597	202	R>K		No	ClinGen gnomAD
TCGA novel	204	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378284463 rs1293794819	209	Q>E		No	ClinGen gnomAD
CA378283881 rs1406204567	210	R>C		No	ClinGen gnomAD
CA378283880 rs1363194440	210	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs990171320 CA214163084	212	H>R		No	ClinGen TOPMed
CA5713808 rs770258900	215	S>T		No	ClinGen ExAC gnomAD
CA378283812 rs1418339157	216	T>A		No	ClinGen gnomAD
CA5713807 rs746446445	216	T>M		No	ClinGen ExAC gnomAD
TCGA novel	217	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713806 rs141344937	218	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1490846075 CA378283758	219	N>T		No	ClinGen gnomAD
rs1266878030 CA378283692	223	P>R		No	ClinGen gnomAD
rs1263075905 CA378283599	228	M>I		No	ClinGen gnomAD
rs1488900317 CA378283610	228	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs148280465 CA214163028	229	H>L		No	ClinGen ESP
CA378283536 rs1355216530	232	T>A		No	ClinGen gnomAD
rs751057698 CA5713804	232	T>S		No	ClinGen ExAC gnomAD
CA378283521 rs1301476769	233	R>G		No	ClinGen gnomAD
rs1224981199 CA378283491	234	L>R		No	ClinGen gnomAD
CA5713801 rs752325040	235	V>A		No	ClinGen ExAC gnomAD
CA5713802 rs758087075	235	V>L		No	ClinGen ExAC
CA378283434 rs1589695582	238	D>A		No	ClinGen Ensembl
rs759319190 CA5713799	239	S>G		No	ClinGen ExAC gnomAD
TCGA novel	242	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1196035001 CA378283015	252	A>V		No	ClinGen gnomAD
rs1487714045 CA378282918	258	G>R		No	ClinGen TOPMed
rs1249115341 CA378282848	263	S>P		No	ClinGen gnomAD
rs1258935321 CA378282834	264	K>E		No	ClinGen TOPMed
rs34481774	265	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1226141213 CA378282801	265	K>N		No	ClinGen TOPMed gnomAD
TCGA novel	266	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA214161837 rs952254	267	P>L		No	ClinGen Ensembl
CA378282747 rs1340975562	269	P>S		No	ClinGen gnomAD
rs901768155 CA378282713	270	Q>H		No	ClinGen gnomAD
CA378282661 CA378282657 rs1336258163	272	M>I		No	ClinGen TOPMed gnomAD
rs1040220007 CA214161831	272	M>L		No	ClinGen gnomAD
CA378282668 rs1564759858	272	M>T		No	ClinGen Ensembl
rs1004662565 CA378282573	276	Y>C		No	ClinGen TOPMed gnomAD
rs1004662565 CA214161814	276	Y>F		No	ClinGen TOPMed gnomAD
rs1166219857 CA378282330	287	G>A		No	ClinGen gnomAD
rs747531147 CA5713769	293	A>S		No	ClinGen ExAC gnomAD
CA378282151 rs1443107580	296	L>F		No	ClinGen TOPMed gnomAD
CA5713766 rs776219979	298	R>C		No	ClinGen ExAC TOPMed gnomAD
CA214161787 rs931360270	298	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA378282080 rs1333195910	301	H>L		No	ClinGen TOPMed
CA378282070 rs1439187661	302	L>F		No	ClinGen gnomAD
TCGA novel	302	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748938713 CA5713763	308	K>R		No	ClinGen ExAC gnomAD
CA378281939 rs1243702155	310	L>F		No	ClinGen gnomAD
CA5713762 rs7908387	313	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1444190826 CA378281834 CA378281840	315	M>I		No	ClinGen gnomAD
rs1279921168 CA378281853	315	M>V		No	ClinGen gnomAD
rs1418833809 CA378279646	318	M>V		No	ClinGen TOPMed
CA378279619 rs1392153459	319	S>A		No	ClinGen gnomAD
rs748949956 CA5713744	319	S>C		No	ClinGen ExAC TOPMed gnomAD
rs779751574 CA5713743	320	T>A		No	ClinGen ExAC gnomAD
rs146445105 CA214156752	321	R>G		No	ClinGen ESP gnomAD
CA378279562 rs1162849712	322	V>I		No	ClinGen TOPMed
CA5713742 rs769274847	323	L>F		No	ClinGen ExAC TOPMed
rs1157562469 CA378279463	327	L>F		No	ClinGen gnomAD
rs971645475 CA214156721	328	S>C		No	ClinGen TOPMed
rs1480556514 CA378279433	329	I>V		No	ClinGen TOPMed gnomAD
rs745681119 CA5713741	330	P>A		No	ClinGen ExAC gnomAD
CA5713740 rs545176741	331	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1023161184 CA378279291	334	E>D		No	ClinGen TOPMed gnomAD
rs199796475 COSM915332 CA5713738	335	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs199796475 CA378279283	335	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777221269 CA5713737	336	T>A		No	ClinGen ExAC gnomAD
rs755084308 CA5713736 COSM244228	336	T>M	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs777221269 CA214156680	336	T>S		No	ClinGen ExAC gnomAD
rs542911129 CA5713735	340	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA378279085 rs1318157300	344	M>T		No	ClinGen TOPMed
rs766634954 CA5713734	347	I>V		No	ClinGen ExAC TOPMed gnomAD
CA214156659 rs554219927	348	I>T		No	ClinGen TOPMed
rs750814731 CA5713732	349	V>G		No	ClinGen ExAC TOPMed gnomAD
CA5713733 rs375817409	349	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713730 rs762356806	354	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5713728 rs768116056	357	T>A		No	ClinGen ExAC gnomAD
rs977034204 CA214156636	359	L>V		No	ClinGen gnomAD
rs1407804417 CA378278784	360	G>S		No	ClinGen gnomAD
rs1173848289 CA378278776	361	L>I		No	ClinGen gnomAD
TCGA novel	362	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs886164216 CA214156620	365	P>L		No	ClinGen TOPMed gnomAD
CA214156621 rs539066982	365	P>S		No	ClinGen Ensembl
CA5713725 rs116978322	366	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5713724 rs745485737	366	T>R		No	ClinGen ExAC TOPMed
CA5713723 rs372394395	368	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs145348629 CA5713722	369	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA214156576 rs374269813	371	I>V		No	ClinGen ESP TOPMed
rs997335180 CA378278455	372	N>D		No	ClinGen TOPMed gnomAD
rs997335180 CA214156572	372	N>H		No	ClinGen TOPMed gnomAD
rs747014383 CA5713721	374	M>T		No	ClinGen ExAC gnomAD
CA214156557 rs901793271	374	M>V		No	ClinGen TOPMed gnomAD
CA378276457 rs1181907488	376	R>G		No	ClinGen gnomAD
rs764686771 CA5713710	377	F>L		No	ClinGen ExAC gnomAD
rs1024136470 CA214152972	378	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	379	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713709 rs763331092	379	V>I		No	ClinGen ExAC TOPMed gnomAD
CA378276324 rs1454409358	381	Q>L		No	ClinGen TOPMed
rs149836727 CA214152952	382	Y>C		No	ClinGen ESP TOPMed gnomAD
CA5713706 rs759323743	385	P>A		No	ClinGen ExAC TOPMed gnomAD
rs967185 VAR_024438 CA214152910	386	E>K		No	ClinGen UniProt Ensembl dbSNP
rs746816340 CA5713703	387	V>L		No	ClinGen ExAC TOPMed gnomAD
CA378276009 rs1439346338	392	N>S	Variant assessed as Somatic; 4.64e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs772075341 CA5713701	393	W>G		No	ClinGen ExAC gnomAD
CA5713700 rs748001196	394	L>I		No	ClinGen ExAC gnomAD
rs1419494565 CA378275558	404	C>G		No	ClinGen gnomAD
rs1419494565 CA378275563	404	C>R		No	ClinGen gnomAD
CA378275430 rs1311348617	406	R>Q		No	ClinGen gnomAD
rs1246770220 CA378275400	407	V>I		No	ClinGen TOPMed
CA378275371 rs1251172647	408	T>A		No	ClinGen TOPMed gnomAD
rs778259276 CA5713673	410	V>G		No	ClinGen ExAC
CA378274921 rs1300430536	412	N>S		No	ClinGen TOPMed gnomAD
TCGA novel rs755496726 CA5713669	413	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
CA5713670 CA5713671 rs773165564	413	W>R		No	ClinGen ExAC gnomAD
CA378274794 rs1286882153	415	R>T		No	ClinGen gnomAD
rs947968887 CA214152364	418	P>L		No	ClinGen TOPMed
CA378274649 rs1388146467	420	K>Q		No	ClinGen gnomAD
CA214152363 rs200274500	421	E>D		No	ClinGen 1000Genomes TOPMed gnomAD
rs765953832 CA5713667	421	E>V		No	ClinGen ExAC gnomAD
CA5713665 rs750027021	422	P>L		No	ClinGen ExAC TOPMed gnomAD
CA378274591 rs750027021	422	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA5713666 rs750027021	422	P>R		No	ClinGen ExAC TOPMed gnomAD
CA5713663 rs774135968	426	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs537661767 CA5713660	429	P>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA5713661 rs768601430	429	P>S		No	ClinGen ExAC
CA378274454 rs1263322442	432	Q>R		No	ClinGen gnomAD
CA378274437 rs1342173195	433	N>S		No	ClinGen gnomAD
CA5713658 rs770985156	434	N>T		No	ClinGen ExAC gnomAD
rs1227587491 CA378274412	435	T>A		No	ClinGen gnomAD
rs1309165203 CA378274389	437	L>F		No	ClinGen TOPMed gnomAD
CA5713657 rs139877301	438	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1434040878 CA378274070 COSM356688	438	R>H	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1159649806 CA378274051	441	Q>L		No	ClinGen TOPMed
rs1589691402 CA378273798	443	V>G		No	ClinGen Ensembl
CA5713583 rs543975402	448	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA5713582 rs777200290	449	S>C		No	ClinGen ExAC TOPMed gnomAD
CA214147042 rs1027319681	449	S>N		No	ClinGen gnomAD
rs777229449 CA5713579	451	E>A		No	ClinGen ExAC gnomAD
rs746547732 CA5713580	451	E>K		No	ClinGen ExAC gnomAD
CA214147004 rs761268231	452	F>L		No	ClinGen Ensembl
rs1230125116 CA378273518	453	S>C		No	ClinGen TOPMed
rs747779644 CA5713577	454	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1340748038 CA378273501	454	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs778628557 CA5713576	456	T>I		No	ClinGen ExAC
rs1297302670 CA378273450	457	S>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	457	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs958821857 CA214146980	459	V>I		No	ClinGen Ensembl
rs1380842080 CA378273382	460	P>L		No	ClinGen gnomAD
CA214146978 rs1035484405	460	P>S		No	ClinGen Ensembl
rs1446584438 CA378273294	464	A>T		No	ClinGen gnomAD
rs1354629287 CA378273274	464	A>V		No	ClinGen gnomAD
CA5713573 rs780050368	466	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA5713571 rs751720763	469	R>Q		No	ClinGen ExAC gnomAD
COSM202531 rs770069171 CA5713572	469	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA378273167 rs1564755188	471	I>T		No	ClinGen Ensembl
CA378273173 rs1163958582	471	I>V		No	ClinGen TOPMed gnomAD
CA214146943 rs866281059	474	A>S		No	ClinGen Ensembl
CA5713569 rs763315303	474	A>V		No	ClinGen ExAC TOPMed gnomAD
rs574995777 CA5713568	475	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs574995777 CA214146937	475	A>T		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	479	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	481	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	482	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758556287 CA5713552	483	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378272906 rs1386065055	484	I>V		No	ClinGen TOPMed
rs1349363557 CA378272888	485	D>N		No	ClinGen TOPMed gnomAD
rs752664993 CA5713551	487	T>N		No	ClinGen ExAC gnomAD
rs372799903 CA378272827	488	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5713550 rs372799903	488	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368536646 CA214146721	489	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs147473317 CA5713548	489	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713549 rs368536646	489	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713546 rs761232172	490	T>A		No	ClinGen ExAC gnomAD
CA5713545 rs549355028	492	S>G		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	494	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1266613051 CA378272723	495	S>F		No	ClinGen TOPMed
rs1192078295 CA378272621	500	A>V		No	ClinGen TOPMed
CA378272606 rs1265946910	502	R>G		No	ClinGen gnomAD
CA378272601 rs1190946752	502	R>Q		No	ClinGen gnomAD
rs893210167 CA214146684	503	E>D		No	ClinGen TOPMed gnomAD
rs1469711052 CA378272546	505	A>V		No	ClinGen Ensembl
rs535803217 CA5713540	506	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs535803217 CA378272532	506	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769698715 CA5713538	510	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs143103280 CA214146633	514	M>I		No	ClinGen ESP
rs991852930 CA214146628	517	E>G		No	ClinGen Ensembl
rs1382524267 CA378272283	519	I>M		No	ClinGen gnomAD
CA5713535 rs757095199	521	N>S		No	ClinGen ExAC gnomAD
TCGA novel	522	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748292540 CA5713534	524	T>S		No	ClinGen ExAC gnomAD
rs1433167655 CA378272200	525	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA378272151 rs1193340684	528	S>L		No	ClinGen gnomAD
rs150218827 CA5713531	531	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150218827 CA214146596	531	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA214146573 rs752035689	532	K>E		No	ClinGen Ensembl
rs924745335 CA214146567	533	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs756470845 CA5713529	536	V>I		No	ClinGen ExAC gnomAD
rs775937350 CA214146537	539	P>L		No	ClinGen Ensembl
CA378271981 rs1187128061	540	A>S		No	ClinGen gnomAD
rs768032312 CA5713527	540	A>V		No	ClinGen ExAC TOPMed gnomAD
rs778146712 CA5713525	541	H>R		No	ClinGen ExAC gnomAD
rs1255276164 CA378271933	542	I>T		No	ClinGen TOPMed gnomAD
rs149307032 CA5713524	542	I>V		No	ClinGen ESP ExAC gnomAD
CA378290579 rs1272127385	544	Q>H		No	ClinGen gnomAD
rs1366723510 CA378290584	544	Q>R		No	ClinGen TOPMed
TCGA novel	545	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368983014 CA378290539	548	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs368983014 CA5713511	548	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA378290527 rs1306232289	549	Q>E		No	ClinGen TOPMed
rs1456050795 CA378290523	549	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA378290515 rs1182234064	550	H>Y		No	ClinGen gnomAD
CA378290503 rs1473306979	551	Q>*		No	ClinGen gnomAD
CA5713509 rs750814876	551	Q>H		No	ClinGen ExAC gnomAD
CA214180671 rs202223201	556	A>T		No	ClinGen 1000Genomes gnomAD
CA378290445 rs1207890993	557	Y>N		No	ClinGen TOPMed gnomAD
CA378290437 rs1354468578	558	L>I		No	ClinGen gnomAD
TCGA novel	561	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378290407 rs1352419006	562	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1286924574 CA378290398	564	E>K		No	ClinGen gnomAD
rs751996758 CA5713506	567	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5713507 rs757829140	567	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	568	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763725528 CA5713505	568	I>N		No	ClinGen ExAC gnomAD
rs1159479377 CA378290355	570	A>V		No	ClinGen gnomAD
CA378290345 rs1458309418	572	R>H		No	ClinGen gnomAD
CA378290339 rs1589690845	573	Q>P		No	ClinGen Ensembl
rs1589690844 CA378290333	574	T>A		No	ClinGen Ensembl
CA5713503 rs775092336	577	E>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	580	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713502 rs765014742	581	R>C		No	ClinGen ExAC gnomAD
CA5713501 rs375953429	581	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1450840543 CA378290264	584	S>G		No	ClinGen gnomAD
rs142475279 CA5713499	584	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747038167 CA378290249	586	N>I		No	ClinGen ExAC gnomAD
rs747038167 CA5713498	586	N>T		No	ClinGen ExAC gnomAD
TCGA novel	588	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713496 rs533743806	596	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1231462271 CA378290116	604	V>A		No	ClinGen gnomAD
rs770042179 CA5713493	605	R>Q	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378290072 rs1398275673	610	E>D		No	ClinGen TOPMed
CA378290047 rs1386077522	613	R>C		No	ClinGen TOPMed gnomAD
rs1386077522 CA378290048	613	R>G		No	ClinGen TOPMed gnomAD
rs781663151 CA5713491	613	R>H		No	ClinGen ExAC gnomAD
rs1334600633 CA378290001	617	K>R		No	ClinGen TOPMed
rs1370864891 CA378289971	620	E>Q		No	ClinGen gnomAD
TCGA novel	623	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751893874 CA5713489	628	H>R		No	ClinGen ExAC
rs1270426651 CA378289841	630	Q>R		No	ClinGen TOPMed
rs1477536131 CA378289759	636	V>I		No	ClinGen gnomAD
CA5713487 rs758936109	639	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1466403883 CA378289570	647	E>Q		No	ClinGen gnomAD
rs759323330 CA5713484	651	K>R		No	ClinGen ExAC gnomAD
CA5713483 rs753431981	656	I>L		No	ClinGen ExAC gnomAD
rs753431981 CA378289417	656	I>V		No	ClinGen ExAC gnomAD
CA214180518 rs199839032	657	D>H		No	ClinGen Ensembl
CA378289393 rs1217987834	657	D>V		No	ClinGen gnomAD
CA378289377 rs1347880001	658	I>T		No	ClinGen gnomAD
CA378289369 rs1240396815	659	E>K		No	ClinGen TOPMed
rs1350990472 CA378289231	660	D>E		No	ClinGen gnomAD
CA5713465 rs765966923	660	D>G		No	ClinGen ExAC gnomAD
rs1427519256 CA378289128	674	V>F		No	ClinGen gnomAD
TCGA novel	678	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1162336340 CA378289031	687	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
VAR_048921 rs431898 CA214179725	694	K>N		No	ClinGen UniProt Ensembl dbSNP
rs1453783196 CA378288978	694	K>R		No	ClinGen TOPMed
TCGA novel	695	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1394470170 CA378288960	695	I>T		No	ClinGen gnomAD
CA5713437 rs766470835	695	I>V		No	ClinGen ExAC TOPMed gnomAD
CA378288945 rs1564754055	697	Y>C		No	ClinGen Ensembl
CA214179605 rs755417206	701	A>S		No	ClinGen gnomAD
CA378288903 rs1389724057	703	R>H		No	ClinGen TOPMed gnomAD
CA5713435 rs773575888	703	R>S		No	ClinGen ExAC gnomAD
CA5713434 rs772366328	704	L>V		No	ClinGen ExAC gnomAD
CA378288888 rs1451757668	705	E>D		No	ClinGen gnomAD
CA5713433 rs774812566	708	P>A		No	ClinGen ExAC gnomAD
CA5713432 rs774812566	708	P>S		No	ClinGen ExAC gnomAD
CA378288871 rs774812566	708	P>T		No	ClinGen ExAC gnomAD
rs1177445051 CA378288858	710	I>L		No	ClinGen TOPMed gnomAD
rs1177445051 CA378288859	710	I>V		No	ClinGen TOPMed gnomAD
rs780837333 CA5713431	712	S>R		No	ClinGen ExAC TOPMed gnomAD
rs779486167 CA5713429	713	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	715	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs944297632 CA214179543	721	D>V		No	ClinGen TOPMed gnomAD
CA378288769 rs1485265610	722	M>T		No	ClinGen gnomAD
CA5713426 rs555453333	722	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1441777776 CA378288760	723	D>G		No	ClinGen TOPMed
rs1589690434 CA378288696	731	E>D		No	ClinGen Ensembl
CA5713406 rs769049420	733	I>V		No	ClinGen ExAC gnomAD
rs577953155 CA5713405	735	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1205544180 CA378287277	736	M>V		No	ClinGen gnomAD
rs1344055760 CA378287236	739	E>G		No	ClinGen gnomAD
CA214175450 rs866978465	740	R>C		No	ClinGen gnomAD
CA214175445 rs935852797	740	R>H		No	ClinGen TOPMed gnomAD
CA5713404 rs138627360	741	E>A		No	ClinGen ESP ExAC gnomAD
CA5713403 rs770141398	743	A>T		No	ClinGen ExAC gnomAD
rs150172410 CA214175426	744	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs150172410 CA5713402	744	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	752	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1312831663 CA378287063	757	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	758	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713398 rs746652013	761	V>I		No	ClinGen ExAC TOPMed gnomAD
CA378287014 rs1461149831	762	M>V		No	ClinGen gnomAD
CA378286995 rs1368724391	763	R>Q		No	ClinGen gnomAD
rs758219482 CA5713397	765	K>R		No	ClinGen ExAC TOPMed gnomAD
rs758219482 CA5713396	765	K>T		No	ClinGen ExAC TOPMed gnomAD
rs141604213 CA5713395	767	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs141604213 CA378286953	767	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA378286949 rs1182819547	768	R>W		No	ClinGen gnomAD
CA5713393 rs137888308	769	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5713392 rs750567204	770	S>T		No	ClinGen ExAC gnomAD
CA5713391 rs767679172	771	V>I		No	ClinGen ExAC TOPMed gnomAD
CA378286919 rs767679172	771	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5713390 rs762181950	772	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA5713367 rs145288541	777	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs978702708 CA214174982	777	K>T		No	ClinGen Ensembl
CA5713366 rs750837378	782	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs775536640 CA214174970	785	E>Q		No	ClinGen gnomAD
rs577816783 CA5713365	787	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA378286673 rs1393491516	788	H>D		No	ClinGen TOPMed
rs1379136826 CA378286663	789	N>D		No	ClinGen gnomAD
rs867187359 CA214174958	790	R>*		No	ClinGen Ensembl
CA5713363 rs772554138	790	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5713364 COSM915326 rs772554138	790	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs771793248 CA378286640	791	L>S		No	ClinGen ExAC gnomAD
rs771793248 CA5713362	791	L>W		No	ClinGen ExAC gnomAD
rs1168732515 CA378286608	794	R>W		No	ClinGen TOPMed
rs747737267 CA5713361	795	K>T		No	ClinGen ExAC TOPMed gnomAD
CA5713360 rs769916354	796	R>G		No	ClinGen ExAC TOPMed gnomAD
CA378286575 rs1448826806	797	Q>L		No	ClinGen gnomAD
CA5713358 rs749026139	799	K>E		No	ClinGen ExAC gnomAD
CA378286530 rs1249974592	801	E>G		No	ClinGen gnomAD
COSM1638452 rs968700901 CA214174912	802	R>H	Variant assessed as Somatic; 0.0 impact. stomach [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA378286517 rs968700901	802	R>L		No	ClinGen TOPMed gnomAD
RCV000960920 rs77382849 CA5713355	803	R>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA378286506 rs1369738240	803	R>S		No	ClinGen gnomAD
rs1029741037 CA214174909	804	I>R		No	ClinGen Ensembl
rs1297912731 CA378286487	805	T>I		No	ClinGen TOPMed gnomAD
rs1297912731 CA378286489	805	T>K		No	ClinGen TOPMed gnomAD
CA5713353 rs758704628	807	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1275579370 CA378286446	809	E>G		No	ClinGen TOPMed
rs1469357428 CA378286440	810	K>E		No	ClinGen TOPMed
rs111676210 CA214174881	813	E>A		No	ClinGen Ensembl
rs1171476562 CA378286399	813	E>K		No	ClinGen gnomAD
rs770493523	814	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA5713347 rs754149398	817	R>T		No	ClinGen ExAC gnomAD
CA5713346 rs372255299	818	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713345 rs761136012	821	Q>E		No	ClinGen ExAC gnomAD
rs772831549 CA5713344	821	Q>H		No	ClinGen ExAC gnomAD
CA5713343 rs766927615	822	M>I		No	ClinGen ExAC gnomAD
CA5713321 rs762663906	826	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5713320 rs775483372	828	E>K		No	ClinGen ExAC TOPMed gnomAD
rs149195320 CA5713319	830	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713318 rs759307585	831	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5713317 rs776444945	831	R>H		No	ClinGen ExAC TOPMed gnomAD
CA378285960 rs776444945	831	R>L		No	ClinGen ExAC TOPMed gnomAD
CA378285964 rs759307585	831	R>S		No	ClinGen ExAC TOPMed gnomAD
rs200404714 CA214174301	832	A>T		No	ClinGen TOPMed gnomAD
rs1461972897 CA378285951	832	A>V		No	ClinGen gnomAD
rs778928763 CA378285948	833	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778928763 CA5713314	833	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA214174289 rs919153860	834	R>G		No	ClinGen TOPMed gnomAD
rs1475147266 CA378285934	834	R>Q		No	ClinGen TOPMed gnomAD
CA5713313 rs768911727	836	K>R		No	ClinGen ExAC gnomAD
CA5713312 rs749503423	837	R>C		No	ClinGen ExAC TOPMed gnomAD
CA378285905 rs749503423	837	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5713311 rs756443319	837	R>H		No	ClinGen ExAC gnomAD
CA5713310 rs756443319	837	R>L		No	ClinGen ExAC gnomAD
rs781574536 CA5713308	838	E>K		No	ClinGen ExAC TOPMed gnomAD
CA378285880 rs1475918890	839	E>G		No	ClinGen TOPMed
CA5713306 rs751156238	842	R>Q		No	ClinGen ExAC gnomAD
rs763675408 CA5713305	844	Y>C		No	ClinGen ExAC gnomAD
CA214174276 rs897165912	847	R>Q		No	ClinGen TOPMed gnomAD
CA5713304 rs762760258	847	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1397025008 CA378285734	852	E>D		No	ClinGen gnomAD
TCGA novel	852	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	853	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764924492 CA5713302	854	V>A		No	ClinGen ExAC
CA5713301 rs374609913	859	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA378285657 rs1346245231	859	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA214174254 rs573093581	860	Q>E		No	ClinGen 1000Genomes gnomAD
CA5713300 rs776444269	860	Q>R		No	ClinGen ExAC gnomAD
CA378285581 rs1250786645	865	I>T		No	ClinGen gnomAD
CA378285563 rs1212471310	867	E>Q		No	ClinGen gnomAD
CA5713295 rs749303672	870	R>L		No	ClinGen ExAC TOPMed gnomAD
CA214174216 rs749303672	870	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs150064739 CA5713296	870	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5713294 rs780272294	871	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5713293 rs372201993	871	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1301700261 CA378285488	874	E>A		No	ClinGen TOPMed gnomAD
CA378285485 rs1301700261	874	E>G		No	ClinGen TOPMed gnomAD
rs1042818436 CA214174213	875	E>A		No	ClinGen TOPMed
rs970104483 CA214174212	876	R>G		No	ClinGen Ensembl
CA5713291 rs781589940	878	L>R		No	ClinGen ExAC gnomAD
CA378285399 rs1440173236	880	D>N		No	ClinGen gnomAD
CA5713288 rs778357598	882	S>C		No	ClinGen ExAC gnomAD
rs746080611 CA378284196	888	S>C		No	ClinGen ExAC TOPMed gnomAD
rs746080611 CA5713275	888	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs776919253 CA5713274	889	R>C		No	ClinGen ExAC TOPMed gnomAD
CA214169522 rs1014028323	889	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA378284191 rs776919253	889	R>S		No	ClinGen ExAC TOPMed gnomAD
CA378284167 rs1347096024	891	G>E		No	ClinGen TOPMed
rs1418987397 CA378284151	893	R>G		No	ClinGen Ensembl
CA5713272 rs147876651	896	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs771329719 CA5713273	896	E>K		No	ClinGen ExAC gnomAD
CA5713270 rs758932223	898	T>I		No	ClinGen ExAC TOPMed gnomAD
CA378284033 rs1484683027	903	P>S		No	ClinGen gnomAD
rs1256512543 CA378284013	905	A>T		No	ClinGen gnomAD
rs1196198919 CA378283995	906	D>V		No	ClinGen gnomAD
CA378283981 rs1481059367	907	S>F		No	ClinGen TOPMed gnomAD
CA214169452 rs897313650	909	W>R		No	ClinGen TOPMed
TCGA novel	910	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	910	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713268 rs769492560	913	P>L		No	ClinGen ExAC gnomAD
rs1294055850 CA378283906	914	P>L		No	ClinGen gnomAD
CA378283895 rs1235668473	915	E>D		No	ClinGen gnomAD
rs202038940 CA5713265	916	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	917	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780944947 CA5713244	920	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1311948696 CA378283801	920	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs751510944 CA378283784 COSM915321	922	E>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs751510944 CA5713242	922	E>Q		No	ClinGen ExAC gnomAD
CA378283761 rs1206222953	924	R>Q		No	ClinGen TOPMed gnomAD
rs199545338 CA214168213	925	D>H		No	ClinGen 1000Genomes
rs759683732 CA5713240	925	D>V		No	ClinGen ExAC TOPMed gnomAD
rs753819887 CA5713239	926	E>G		No	ClinGen ExAC gnomAD
CA5713238 rs369943865	927	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA378283725 rs369943865	927	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1371226414 CA378283698	930	H>Y		No	ClinGen gnomAD
CA378283679 rs1305182255	931	R>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	932	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773767917 CA5713236	932	R>G		No	ClinGen ExAC gnomAD
CA378283631 rs1318482622	935	E>G		No	ClinGen gnomAD
CA5713235 rs772556791	935	E>K		No	ClinGen ExAC gnomAD
CA378283623 rs774940035 COSM320090	936	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5713233 rs774940035	936	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5713234 rs762013834	936	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1589685475 CA378283616	937	P>S		No	ClinGen Ensembl
CA5713230 rs779403737	938	R>P		No	ClinGen ExAC gnomAD
CA378283606 rs779403737	938	R>Q		No	ClinGen ExAC gnomAD
rs768154603 CA5713231	938	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5713229 rs769486420	939	R>C		No	ClinGen ExAC TOPMed gnomAD
rs186145626 CA5713227	939	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5713228 rs186145626	939	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1449190712 CA378283575	942	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs142152144 CA5713226	942	D>N		No	ClinGen ESP ExAC gnomAD
CA5713225 rs142152144	942	D>Y		No	ClinGen ESP ExAC gnomAD
rs747894931 CA214168146	945	D>H		No	ClinGen Ensembl
rs1260302211 CA378283500	948	P>L		No	ClinGen gnomAD
rs1392725807 CA378283505	948	P>S		No	ClinGen TOPMed
CA5713224 rs777796020	949	S>T		No	ClinGen ExAC TOPMed gnomAD
CA5713223 rs200680965	950	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378283466 rs1343901895	952	P>R		No	ClinGen gnomAD
rs962014575 CA214168115	952	P>S		No	ClinGen TOPMed gnomAD
rs761041318 CA5713220	954	D>N		No	ClinGen ExAC TOPMed gnomAD
CA378283443 rs1225512854	954	D>V		No	ClinGen gnomAD
CA378283423 rs1373174427 COSM915319	956	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5713219 rs144099570	956	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1415390218 CA378283413	957	V>A		No	ClinGen gnomAD
CA5713217 COSM1739668 rs762264416	958	P>S	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5713215 rs558278066	959	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA5713214 rs558278066	959	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA5713216 RCV000882835 rs372977820	959	R>W		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1424754541 CA378283393	960	R>C		No	ClinGen TOPMed gnomAD
COSM1346095 CA5713213 rs775041698	960	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA378283379 rs1476435369	961	G>D		No	ClinGen gnomAD
rs769290054 CA5713212	962	M>L		No	ClinGen ExAC TOPMed gnomAD
CA378283345 rs1456544980	964	D>G		No	ClinGen TOPMed
CA5713211 rs745318119	964	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756368951 CA5713209	966	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1441428483 CA378283309	967	G>V		No	ClinGen gnomAD
rs746859660 CA5713208	968	P>S		No	ClinGen ExAC gnomAD
CA378283283 rs1336870426	970	R>C		No	ClinGen gnomAD
rs555999896 CA5713207	970	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs555999896 CA378283280	970	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758416031 CA5713206	971	G>S		No	ClinGen ExAC TOPMed gnomAD
CA378283260 rs1357346389	972	P>L		No	ClinGen gnomAD
CA378283253 rs1447055905	973	E>G		No	ClinGen TOPMed gnomAD
CA5713205 rs748028122	973	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs376222097 CA5713203	977	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713204 rs778923892	977	F>L		No	ClinGen ExAC TOPMed gnomAD
CA214167958 rs757331563	979	R>C		No	ClinGen Ensembl
CA5713202 rs201081411	979	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5713201 rs767887874	980	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5713200 rs757392562	980	R>H		No	ClinGen ExAC gnomAD
rs763586296 CA5713197	981	G>A		No	ClinGen ExAC TOPMed gnomAD
CA5713199 rs752007958	981	G>R		No	ClinGen ExAC gnomAD
rs763586296 CA5713198	981	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	982	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138166626 CA5713194	984	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs149533913 CA5713195	984	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA214167907 rs141034070	986	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs553684707 CA5713192	986	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs141034070 CA5713193	986	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773122822 CA5713191	987	P>S		No	ClinGen ExAC gnomAD
CA5713190 rs773122822	987	P>T		No	ClinGen ExAC gnomAD
TCGA novel	989	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378283147 rs1336808201	990	R>C		No	ClinGen TOPMed gnomAD
rs771764319 COSM1638451 CA5713189	990	R>H	Variant assessed as Somatic; 0.0 impact. stomach [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA378283135 rs1227473183	992	T>A		No	ClinGen gnomAD
CA5713187 RCV000965864 VAR_048922 rs532138	993	D>E		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs747890771 CA5713188	993	D>N		No	ClinGen ExAC TOPMed gnomAD
CA378283120 rs1468871697	994	D>G		No	ClinGen TOPMed
rs754930416 CA5713186	995	D>N		No	ClinGen ExAC gnomAD
CA378283078 rs1265180345	998	P>R		No	ClinGen TOPMed
CA5713185 rs369661440 COSM3790518	998	P>S	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA378283074 rs1397236426	999	R>G		No	ClinGen gnomAD
COSM271236 CA5713183 rs757558927	1000	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1193607748 CA378283041	1002	A>T		No	ClinGen TOPMed
CA5713180 rs375163326	1006	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713179 rs200447155	1008	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5713178 rs550694488 COSM915318	1010	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1193642105 CA378282943	1010	R>H		No	ClinGen TOPMed gnomAD
CA378282936 COSM915316 rs1292348830	1011	H>R	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA5713177 rs372236521	1012	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1270788974 CA378282910	1013	D>G		No	ClinGen TOPMed gnomAD
CA378282907 rs1270788974	1013	D>V		No	ClinGen TOPMed gnomAD
CA378282902 rs1293993952	1014	D>H		No	ClinGen TOPMed
rs1334351723 CA378282818	1021	G>R		No	ClinGen TOPMed
TCGA novel	1022	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1219449553 CA378282803	1022	L>P		No	ClinGen TOPMed
rs765798154 CA5713173	1023	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1182676002 CA378282771	1025	D>Y		No	ClinGen Ensembl
CA214167868 rs923086240	1028	S>R		No	ClinGen TOPMed gnomAD
rs1291905279 CA378282703	1030	R>*		No	ClinGen gnomAD
COSM172252 CA5713171 rs138563024	1030	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs771703503 CA5713170	1031	T>I		No	ClinGen ExAC gnomAD
CA214167847 rs940397442	1033	D>E		No	ClinGen Ensembl
rs761734463 CA5713169	1033	D>V		No	ClinGen ExAC gnomAD
CA5713167 rs368710619	1040	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1040	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368710619 CA5713168	1040	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000890858 CA5713166 rs113389368	1042	M>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs113389368 CA378282535	1042	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1308934575 CA378282464	1045	D>E		No	ClinGen gnomAD
rs1455360863 CA378282457	1046	R>Q		No	ClinGen gnomAD
rs141022993 RCV000888708 CA5713165	1046	R>W		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs770920278 CA5713164	1047	G>R		No	ClinGen ExAC gnomAD
rs777887330 CA5713162	1048	P>L		No	ClinGen ExAC gnomAD
rs375001473 CA5713160	1050	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	1052	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779235561 CA5713159	1052	G>V		No	ClinGen ExAC TOPMed gnomAD
CA378282372 rs1454714579	1053	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5713156 rs766849461	1055	D>V		No	ClinGen ExAC gnomAD
CA378282291 rs1386316965	1057	R>Q		No	ClinGen TOPMed gnomAD
CA378282262 rs1291160135	1059	S>Y		No	ClinGen gnomAD
CA378282233 COSM1346093 rs1360285001	1061	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1166840 CA5713152 rs761540126	1061	R>H	ovary large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1360285001 CA378282237	1061	R>S		No	ClinGen gnomAD
TCGA novel	1063	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs998310900 CA214167764	1064	D>N		No	ClinGen TOPMed
rs774350369 CA5713151	1065	D>E		No	ClinGen ExAC gnomAD
rs1436171631 CA378281446	1065	D>N		No	ClinGen TOPMed gnomAD
rs768568095 CA5713150	1066	D>G		No	ClinGen ExAC
rs1174695568 CA378281430	1066	D>N		No	ClinGen gnomAD
rs775305152 CA5713148	1067	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1296985 rs762770253 CA5713149	1067	R>W	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs769724773 CA5713147	1068	G>C		No	ClinGen ExAC gnomAD
rs769724773 CA378281415	1068	G>R		No	ClinGen ExAC gnomAD
rs201238784 CA5713146	1068	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5713144 rs777884334	1069	P>S		No	ClinGen ExAC TOPMed
rs1487958304 CA378281393	1070	R>S		No	ClinGen TOPMed gnomAD
CA378281390 rs1257943849	1071	R>*		No	ClinGen TOPMed gnomAD
CA378281381 rs772338128	1071	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5713143 rs772338128	1071	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs748364566 CA214165723	1073	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1158648540 CA378281367	1073	L>M		No	ClinGen TOPMed
rs1158648540 CA378281366	1073	L>V		No	ClinGen TOPMed
rs754180203 CA5713140	1075	D>E		No	ClinGen ExAC TOPMed
rs779036916 CA5713141	1075	D>N		No	ClinGen ExAC
CA214165719 rs367644732	1076	D>H		No	ClinGen ESP TOPMed
rs780453479 CA5713138	1076	D>V		No	ClinGen ExAC
CA214165685 rs375388729	1077	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed
CA378281301 rs1299972532	1078	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1374228102 CA378281276	1080	R>K		No	ClinGen TOPMed
rs564332910 CA214165664	1083	M>I		No	ClinGen 1000Genomes
rs533403831 CA378281249	1083	M>L		No	ClinGen 1000Genomes TOPMed gnomAD
rs533403831 CA214165681	1083	M>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA378281193 rs1589685217	1086	D>G		No	ClinGen Ensembl
rs935515675 CA378281184	1087	R>G		No	ClinGen TOPMed gnomAD
COSM1205116 CA214165652 rs935515675	1087	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs756616657 CA214165624	1088	G>D		No	ClinGen ExAC gnomAD
rs756616657 CA5713135	1088	G>V		No	ClinGen ExAC gnomAD
CA378281163 rs1313816458	1089	P>A		No	ClinGen gnomAD
CA378281164 rs1313816458	1089	P>T		No	ClinGen gnomAD
rs199981646 CA5713134	1091	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA378281113 rs1252698690	1093	M>L		No	ClinGen TOPMed
rs544546288 CA5713130	1097	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201878122 CA5713131	1097	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1251456087 CA378281040	1098	G>C		No	ClinGen gnomAD
rs1462225490 CA378281027	1099	P>L		No	ClinGen gnomAD
CA5713129 rs370630701	1101	R>Q		No	ClinGen ESP ExAC TOPMed
rs370517625 CA5713127	1103	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA378280982 rs763781681 CA5713128	1103	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1564749174 CA378280959	1104	D>V		No	ClinGen Ensembl
CA378280953 rs1486418182	1105	D>Y		No	ClinGen gnomAD
rs1172881357 CA378280922	1106	D>V		No	ClinGen TOPMed
CA5713126 rs775316858	1107	R>W		No	ClinGen ExAC TOPMed gnomAD
rs759503994 CA378280874	1111	R>P		No	ClinGen ExAC TOPMed
CA5713124 rs759503994	1111	R>Q		No	ClinGen ExAC TOPMed
CA214165548 rs1045446907	1112	G>R		No	ClinGen TOPMed
TCGA novel	1112	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713121 rs746516522	1113	L>M		No	ClinGen ExAC TOPMed gnomAD
rs746516522 CA378280863	1113	L>V		No	ClinGen ExAC TOPMed gnomAD
CA5713120 rs143496426	1113	L>W		No	ClinGen 1000Genomes ExAC gnomAD
CA378280849 rs1366733174	1114	D>V		No	ClinGen TOPMed
CA214165522 rs567901745	1117	R>G		No	ClinGen Ensembl
CA214165509 rs768823906	1117	R>L		No	ClinGen ExAC gnomAD
rs768823906 CA5713119 COSM293817	1117	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5713117 rs749657975	1118	G>R		No	ClinGen ExAC TOPMed
rs780445995 CA5713116	1118	G>V		No	ClinGen ExAC TOPMed
rs756641321 CA378280728 CA378280730	1122	N>K		No	ClinGen ExAC TOPMed gnomAD
CA5713114 rs746385539	1123	A>T		No	ClinGen ExAC gnomAD
CA5713110 rs763871929	1124	D>E		No	ClinGen ExAC TOPMed gnomAD
rs756841124 CA5713112	1124	D>N		No	ClinGen ExAC gnomAD
rs1235459385 CA378280668	1125	D>G		No	ClinGen gnomAD
CA378280646 rs1564749117	1126	D>A		No	ClinGen Ensembl
rs758045564 CA5713108	1127	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1312539891 CA378280638	1127	R>K		No	ClinGen TOPMed gnomAD
CA378280618 rs1188622119	1128	I>M		No	ClinGen TOPMed
CA378280604 rs1564749098	1129	P>L		No	ClinGen Ensembl
rs765075620 CA378280571	1131	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs186488697 CA5713105	1131	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765075620 CA5713106	1131	R>S		No	ClinGen ExAC TOPMed gnomAD
rs766251297 CA5713103	1135	D>V		No	ClinGen ExAC gnomAD
rs201036917 CA5713102	1136	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs774380221 CA5713101	1137	R>G		No	ClinGen ExAC TOPMed gnomAD
rs375187185 CA5713100	1138	G>S		No	ClinGen ESP ExAC gnomAD
rs749516209 CA5713099	1139	P>H		No	ClinGen ExAC gnomAD
CA378280411 rs1240295386	1141	R>K		No	ClinGen gnomAD
CA5713097 rs770203283	1141	R>S		No	ClinGen ExAC gnomAD
CA5713095 rs781770355	1143	M>V		No	ClinGen ExAC gnomAD
CA5713094 rs757801252	1145	D>G		No	ClinGen ExAC gnomAD
rs1434085900 CA378280350	1145	D>N		No	ClinGen TOPMed
rs1354908359 CA378280336	1146	D>H		No	ClinGen gnomAD
CA5713092 rs202128409	1147	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5713093 rs202128409	1147	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1340768719 CA378280327 COSM3414737	1147	R>H	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA378280325 rs1408257776	1148	L>F		No	ClinGen gnomAD
CA378280318 rs1217575756	1149	S>P		No	ClinGen TOPMed
rs557261501 CA214165351	1150	R>G		No	ClinGen gnomAD
CA5713091 rs758053186	1151	R>C		No	ClinGen ExAC gnomAD
CA5713090 rs752397968	1151	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378280296 rs1395512633	1153	D>H		No	ClinGen TOPMed gnomAD
rs1395512633 CA378280297	1153	D>N		No	ClinGen TOPMed gnomAD
rs754819756 CA5713088	1156	R>G		No	ClinGen ExAC TOPMed
rs753587192 CA5713087	1156	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5713089 rs754819756	1156	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
rs967872513 CA214165332	1157	F>L		No	ClinGen Ensembl
CA5713083 rs751698823	1160	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs760586367 CA5713084	1160	R>W		No	ClinGen ExAC TOPMed gnomAD
rs764157875 CA5713082	1161	G>R		No	ClinGen ExAC gnomAD
rs1454706308 CA378280244	1161	G>V		No	ClinGen TOPMed gnomAD
rs771565726 CA5713081	1162	D>G		No	ClinGen ExAC TOPMed gnomAD
rs771565726 CA5713080	1162	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1439387846 CA378280183	1166	P>L		No	ClinGen gnomAD
rs769860513 CA5713079	1166	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA378280166 rs1253666293	1168	P>S		No	ClinGen gnomAD
CA378280117 rs373036457	1171	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713076 rs373036457	1171	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5713075 rs373036457	1171	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs777107645 CA5713077	1171	P>T		No	ClinGen ExAC
CA378280112 rs1356283894	1172	L>V		No	ClinGen TOPMed gnomAD
rs996845744 CA214165213	1176	G>R		No	ClinGen TOPMed
rs996845744 CA378280068	1176	G>S		No	ClinGen TOPMed
rs953399459 CA214162359	1183	K>E		No	ClinGen TOPMed
CA214162352 rs867942878	1184	A>D		No	ClinGen gnomAD
CA378279147 rs867942878	1184	A>V		No	ClinGen gnomAD
rs1052843926 CA214162334	1187	E>V		No	ClinGen Ensembl
CA5713057 rs777200105	1188	S>R		No	ClinGen ExAC
CA214162323 rs935426768	1190	G>V		No	ClinGen Ensembl
CA214162307 rs751651440	1192	P>L		No	ClinGen TOPMed
rs1270332963 CA378279049	1193	R>Q		No	ClinGen TOPMed gnomAD
CA5713056 COSM427136 rs771425860	1198	S>L	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5713055 rs538619754	1199	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs773874233 CA5713054	1201	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1181463664 CA378278906	1203	W>C		No	ClinGen TOPMed
rs1336390719 CA378278890	1204	D>G		No	ClinGen gnomAD
rs772415756 CA5713053	1204	D>N		No	ClinGen ExAC gnomAD
CA5713052 rs747731853	1205	R>K		No	ClinGen ExAC gnomAD
rs1401546935 CA378278854	1206	E>G		No	ClinGen gnomAD
CA378278861 rs1411162993	1206	E>K		No	ClinGen TOPMed
CA214162235 rs1000427843	1207	K>E		No	ClinGen TOPMed
CA378278817 rs768415718	1208	E>K		No	ClinGen ExAC gnomAD
CA5713050 rs768415718	1208	E>Q		No	ClinGen ExAC gnomAD
CA5713048 rs748938813	1209	R>S		No	ClinGen ExAC gnomAD
CA5713047 rs779619328	1210	D>E		No	ClinGen ExAC gnomAD
rs904784348 CA214162198	1210	D>H		No	ClinGen TOPMed
CA5713046 rs755920883	1211	R>K		No	ClinGen ExAC gnomAD
rs750170136 CA5713045	1212	D>N		No	ClinGen ExAC TOPMed gnomAD
CA378278679 rs756916885	1216	R>G		No	ClinGen ExAC TOPMed gnomAD
rs979442279 CA378278672	1216	R>L		No	ClinGen TOPMed
rs979442279 CA214162145	1216	R>Q		No	ClinGen TOPMed
CA5713044 rs756916885	1216	R>W		No	ClinGen ExAC TOPMed gnomAD
rs972766859	1218	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1218	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5713041 rs765226054	1220	D>G		No	ClinGen ExAC gnomAD
rs752873980 CA5713042	1220	D>N		No	ClinGen ExAC gnomAD
CA5713040 rs372256456	1223	P>S		No	ClinGen ESP ExAC gnomAD
rs62636533 CA378278489	1227	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs62636533 CA378278486	1227	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1282253553 CA378278404	1230	E>Q		No	ClinGen gnomAD
CA5713037 rs761147859	1232	D>E		No	ClinGen ExAC gnomAD
rs1348087146 CA378278308	1234	D>H		No	ClinGen TOPMed
CA5713035 rs372153021	1235	R>Q		No	ClinGen ESP ExAC gnomAD
CA5713034 rs768115339	1237	D>E		No	ClinGen ExAC TOPMed gnomAD
CA378278192 rs1398665610	1238	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA378278102 rs1406527803	1242	P>A		No	ClinGen gnomAD
CA5712999 rs750616860	1244	D>H		No	ClinGen ExAC TOPMed gnomAD
CA5712997 rs757589056	1246	G>D		No	ClinGen ExAC gnomAD
CA5712998 rs781420362	1246	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1248	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378277468 rs1381458582	1252	P>L		No	ClinGen TOPMed
CA5712996 rs751916228	1254	E>Q		No	ClinGen ExAC gnomAD
rs1209489108 CA378277417	1256	S>P		No	ClinGen gnomAD
CA378277332 rs1354455378	1261	D>E		No	ClinGen gnomAD
CA5712993 rs61729183	1262	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs367880512 CA5712992	1262	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs61729183 CA378277330	1262	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1359438745 CA378277317	1263	S>R		No	ClinGen gnomAD
CA5712990 rs375737679	1264	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs375737679 CA5712989	1264	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs938443375 CA214160671	1264	R>H		No	ClinGen TOPMed
CA214160654 rs938443375	1264	R>L		No	ClinGen TOPMed
rs1174804378 CA378277282	1265	R>Q		No	ClinGen TOPMed gnomAD
CA378277286 rs1356900239	1265	R>W		No	ClinGen TOPMed gnomAD
COSM1627337 rs371292579 CA5712986	1267	D>N	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs371292579 CA378277269	1267	D>Y		No	ClinGen ESP ExAC gnomAD
rs1372198669 CA378277254	1269	D>G		No	ClinGen TOPMed gnomAD
rs773789741 CA214160628	1269	D>H		No	ClinGen Ensembl
CA5712984 rs575153277	1270	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA214160608 rs977098875	1272	D>H		No	ClinGen Ensembl
CA5712983 rs769778705 COSM3741516	1273	R>C	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA378277227 rs769778705	1273	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5712982 rs745913298	1274	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5712981 rs368318464	1274	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1717040 rs757474711 CA378277218	1275	R>C	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs757474711 CA5712980	1275	R>G		No	ClinGen ExAC TOPMed gnomAD
rs751921377 CA5712979	1275	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5712978 rs778100804	1276	E>D		No	ClinGen ExAC
rs556140038 CA5712977	1277	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA378277200 rs1217401144	1278	D>Y		No	ClinGen gnomAD
CA378277192 rs1340291542	1279	D>Y		No	ClinGen gnomAD
CA378277185 rs1397394876	1280	R>Q		No	ClinGen gnomAD
CA5712976 rs373914277	1280	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs765681749 CA5712974	1281	R>C		No	ClinGen ExAC gnomAD
rs758996792 CA5712973	1281	R>H		No	ClinGen ExAC TOPMed
CA5712972 rs144110377	1282	D>A		No	ClinGen ESP ExAC TOPMed
rs765995915 CA5712971	1282	D>E		No	ClinGen ExAC
CA5712970 rs139392109	1283	L>V		No	ClinGen ESP ExAC TOPMed
CA214160540 rs986470247	1285	E>K		No	ClinGen Ensembl
rs773207250 CA5712969	1287	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5712968 rs771994561	1288	D>A		No	ClinGen ExAC TOPMed gnomAD
rs761644603 CA5712967	1289	L>I		No	ClinGen ExAC gnomAD
rs774454537 CA378277118	1291	D>E		No	ClinGen ExAC TOPMed gnomAD
rs768599574 CA5712965	1292	D>N		No	ClinGen ExAC gnomAD
CA5712964 rs745975112	1294	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	1297	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1425741135 COSM347391 CA378277066	1299	P>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1166686643 CA378277071	1299	P>S		No	ClinGen gnomAD
rs1256239115 CA378277061	1300	L>P		No	ClinGen TOPMed
CA5712962 rs771120379	1302	S>P		No	ClinGen ExAC gnomAD
rs747229908 CA5712961	1303	E>Q		No	ClinGen ExAC gnomAD
rs777907958 CA5712960	1303	E>V		No	ClinGen ExAC gnomAD
CA5712959 rs548083661	1304	R>C		No	ClinGen ExAC gnomAD
CA378277039 COSM1346089 rs1484391111	1304	R>H	liver large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA5712958 rs748468977	1305	E>K		No	ClinGen ExAC gnomAD
rs1389706388 CA378276997	1308	S>R		No	ClinGen gnomAD
CA378276993 rs1345089132	1309	S>F		No	ClinGen TOPMed
rs762591865 CA5712906	1309	S>T		No	ClinGen ExAC gnomAD
CA378276991 rs1345089132	1309	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1198102384 CA378276986	1310	W>S		No	ClinGen TOPMed
CA5712905 rs775513192	1312	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378276962 rs1156852412	1314	D>N		No	ClinGen TOPMed gnomAD
rs1437626830 CA378276951	1315	D>G		No	ClinGen TOPMed
TCGA novel	1316	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs192094747 CA5712899 COSM1284713	1320	R>G	Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5712898 rs769076103	1320	R>Q		No	ClinGen ExAC gnomAD
rs192094747 CA5712900	1320	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5712896 rs780643908	1323	E>A		No	ClinGen ExAC gnomAD
CA5712897 rs146276916	1323	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1345108493 CA378276833	1324	R>Q		No	ClinGen gnomAD
CA5712895 rs770393981	1324	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1368189119 CA378276812	1325	D>V		No	ClinGen gnomAD
rs569387973 CA214159418	1326	P>S		No	ClinGen TOPMed gnomAD
CA5712894 rs141499066	1327	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757041285 CA5712893 COSM232238	1328	R>C	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5712892 rs757041285	1328	R>G		No	ClinGen ExAC gnomAD
rs1435304837 CA378276767	1328	R>H		No	ClinGen gnomAD
CA5712891 rs751232721	1329	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs541720445 CA214159407	1329	R>P		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	1330	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5712890 COSM1739699 rs202161257	1330	V>F	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs758241791 CA5712889	1332	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs373800925 CA5712887	1333	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373800925 CA378276701	1333	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs374146406 CA5712888	1333	P>S		No	ClinGen ESP ExAC gnomAD
rs1464950776 CA378276688	1334	A>P		No	ClinGen gnomAD
rs1324744346 CA378276678	1334	A>V		No	ClinGen TOPMed
CA5712882 rs766037789	1336	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA5712885 rs750568100	1336	S>L		No	ClinGen ExAC gnomAD
CA5712884 rs767588363	1338	D>G		No	ClinGen ExAC gnomAD
rs761822661 CA378275946	1339	R>*		No	ClinGen ExAC gnomAD
rs761822661 CA5712883	1339	R>G		No	ClinGen ExAC gnomAD
CA378275938 rs1261567281	1339	R>L		No	ClinGen TOPMed gnomAD
COSM915311 rs1261567281 CA378275942	1339	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA5712881 rs774654035	1341	R>G		No	ClinGen ExAC gnomAD
rs1589682505 CA378275865	1342	D>G		No	ClinGen Ensembl
COSM915310 CA5712879 rs763416725	1343	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5712880 rs763416725	1343	R>G		No	ClinGen ExAC gnomAD
CA378275841 rs1198258688	1343	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs775695722 CA5712875	1345	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5712874 rs770481796	1346	E>D		No	ClinGen ExAC TOPMed
rs1220457851 CA378275710	1348	E>K		No	ClinGen gnomAD
rs781738727 CA5712869	1349	G>D		No	ClinGen ExAC gnomAD
CA5712870 rs746376951	1349	G>R		No	ClinGen ExAC gnomAD
CA5712867 rs375661097	1351	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1336176802 CA378275511	1353	K>E		No	ClinGen gnomAD
CA5712866 rs777520032	1353	K>N		No	ClinGen ExAC gnomAD
rs915716740 CA214159209	1354	A>S		No	ClinGen TOPMed
rs915716740 CA378275479	1354	A>T		No	ClinGen TOPMed
rs1405517537 CA378275433	1354	A>V		No	ClinGen gnomAD
CA5712865 rs757963072	1355	S>*		No	ClinGen ExAC TOPMed gnomAD
CA5712863 rs778671067	1362	R>T		No	ClinGen ExAC TOPMed gnomAD
CA5712862 rs754701550	1364	S>C		No	ClinGen ExAC TOPMed gnomAD
rs753786295 CA5712861	1366	R>C		No	ClinGen ExAC gnomAD
rs143903271 CA5712859	1366	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5712860 rs143903271	1366	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs751564493 CA5712858	1367	R>C		No	ClinGen ExAC gnomAD
CA5712857 COSM915308 rs764426395	1367	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1353305064 CA378274840	1371	E>D		No	ClinGen gnomAD
CA5712856 rs578051436	1372	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378274684 rs1271976016	1377	W>*		No	ClinGen gnomAD
TCGA novel	1377	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357250841 CA378274626 COSM915307	1381	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1251078 rs1271648760 CA378274621	1381	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
CA5712854 rs765705109	1382	R>C		No	ClinGen ExAC gnomAD

No associated diseases with Q14152

1 regional properties for Q14152

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	315 - 506	IPR000717

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic 43S preinitiation complex	A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex	A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex	A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
eukaryotic translation initiation factor 3 complex, eIF3e	An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
eukaryotic translation initiation factor 3 complex, eIF3m	An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
multi-eIF complex	A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.

4 GO annotations of molecular function

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
translation initiation factor activity	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

5 GO annotations of biological process

Name	Definition
formation of cytoplasmic translation initiation complex	Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
IRES-dependent viral translational initiation	Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.
translation reinitiation	A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
viral translational termination-reinitiation	A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38249	RPG1	Eukaryotic translation initiation factor 3 subunit A	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9XHR2	TIF3A1	Eukaryotic translation initiation factor 3 subunit A	Zea mays (Maize)	PR
P23116	Eif3a	Eukaryotic translation initiation factor 3 subunit A	Mus musculus (Mouse)	PR
Q9LD55	TIF3A1	Eukaryotic translation initiation factor 3 subunit A	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MPAYFQRPEN	ALKRANEFLE	VGKKQPALDV	LYDVMKSKKH	RTWQKIHEPI	MLKYLELCVD
70	80	90	100	110	120
LRKSHLAKEG	LYQYKNICQQ	VNIKSLEDVV	RAYLKMAEEK	TEAAKEESQQ	MVLDIEDLDN
130	140	150	160	170	180
IQTPESVLLS	AVSGEDTQDR	TDRLLLTPWV	KFLWESYRQC	LDLLRNNSRV	ERLYHDIAQQ
190	200	210	220	230	240
AFKFCLQYTR	KAEFRKLCDN	LRMHLSQIQR	HHNQSTAINL	NNPESQSMHL	ETRLVQLDSA
250	260	270	280	290	300
ISMELWQEAF	KAVEDIHGLF	SLSKKPPKPQ	LMANYYNKVS	TVFWKSGNAL	FHASTLHRLY
310	320	330	340	350	360
HLSREMRKNL	TQDEMQRMST	RVLLATLSIP	ITPERTDIAR	LLDMDGIIVE	KQRRLATLLG
370	380	390	400	410	420
LQAPPTRIGL	INDMVRFNVL	QYVVPEVKDL	YNWLEVEFNP	LKLCERVTKV	LNWVREQPEK
430	440	450	460	470	480
EPELQQYVPQ	LQNNTILRLL	QQVSQIYQSI	EFSRLTSLVP	FVDAFQLERA	IVDAARHCDL
490	500	510	520	530	540
QVRIDHTSRT	LSFGSDLNYA	TREDAPIGPH	LQSMPSEQIR	NQLTAMSSVL	AKALEVIKPA
550	560	570	580	590	600
HILQEKEEQH	QLAVTAYLKN	SRKEHQRILA	RRQTIEERKE	RLESLNIQRE	KEELEQREAE
610	620	630	640	650	660
LQKVRKAEEE	RLRQEAKERE	KERILQEHEQ	IKKKTVRERL	EQIKKTELGA	KAFKDIDIED
670	680	690	700	710	720
LEELDPDFIM	AKQVEQLEKE	KKELQERLKN	QEKKIDYFER	AKRLEEIPLI	KSAYEEQRIK
730	740	750	760	770	780
DMDLWEQQEE	ERITTMQLER	EKALEHKNRM	SRMLEDRDLF	VMRLKAARQS	VYEEKLKQFE
790	800	810	820	830	840
ERLAEERHNR	LEERKRQRKE	ERRITYYREK	EEEEQRRAEE	QMLKEREERE	RAERAKREEE
850	860	870	880	890	900
LREYQERVKK	LEEVERKKRQ	RELEIEERER	RREEERRLGD	SSLSRKDSRW	GDRDSEGTWR
910	920	930	940	950	960
KGPEADSEWR	RGPPEKEWRR	GEGRDEDRSH	RRDEERPRRL	GDDEDREPSL	RPDDDRVPRR
970	980	990	1000	1010	1020
GMDDDRGPRR	GPEEDRFSRR	GADDDRPSWR	NTDDDRPPRR	IADEDRGNWR	HADDDRPPRR
1030	1040	1050	1060	1070	1080
GLDEDRGSWR	TADEDRGPRR	GMDDDRGPRR	GGADDERSSW	RNADDDRGPR	RGLDDDRGPR
1090	1100	1110	1120	1130	1140
RGMDDDRGPR	RGMDDDRGPR	RGMDDDRGPR	RGLDDDRGPW	RNADDDRIPR	RGAEDDRGPW
1150	1160	1170	1180	1190	1200
RNMDDDRLSR	RADDDRFPRR	GDDSRPGPWR	PLVKPGGWRE	KEKAREESWG	PPRESRPSEE
1210	1220	1230	1240	1250	1260
REWDREKERD	RDNQDREEND	KDPERERDRE	RDVDREDRFR	RPRDEGGWRR	GPAEESSSWR
1270	1280	1290	1300	1310	1320
DSSRRDDRDR	DDRRRERDDR	RDLRERRDLR	DDRDRRGPPL	RSEREEVSSW	RRADDRKDDR
1330	1340	1350	1360	1370	1380
VEERDPPRRV	PPPALSRDRE	RDRDREREGE	KEKASWRAEK	DRESLRRTKN	ETDEDGWTTV

RR