Q9JLB0

PR
Gene name
Pals2
Protein name
Protein PALS2
Names
Dlgh4 protein, MAGUK p55 subfamily member 6, P55T protein, Protein associated with Lin-7 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:56524
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

72-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JLB0

Entry ID Method Resolution Chain Position Source
AF-Q9JLB0-F1 Predicted AlphaFoldDB

23 variants for Q9JLB0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388812964 134 K>I No EVA
rs3388816911 144 F>I No EVA
rs3388835903 145 R>I No EVA
rs1133823446 162 I>T No EVA
rs3388807980 187 K>R No EVA
rs3396733428 204 I>T No EVA
rs3388807966 210 D>E No EVA
rs1134656673 219 V>I No EVA
rs3388812949 220 N>S No EVA
rs1133431418 221 M>I No EVA
rs1134448959 222 E>K No EVA
rs3388796950 332 F>I No EVA
rs3388823300 335 H>Q No EVA
rs3388826274 347 P>Q No EVA
rs3388835091 392 E>D No EVA
rs3388828670 392 E>Q No EVA
rs3388829973 438 V>D No EVA
rs3388830404 447 L>S No EVA
rs3396582454 447 L>V No EVA
rs3388820005 449 V>I No EVA
rs3388826265 481 H>Q No EVA
rs3388828582 535 T>I No EVA
rs3388813012 537 I>T No EVA

No associated diseases with Q9JLB0

13 regional properties for Q9JLB0

Type Name Position InterPro Accession
domain Protein kinase domain 637 - 900 IPR000719
domain Ephrin receptor ligand binding domain 31 - 213 IPR001090
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 637 - 896 IPR001245
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 189 - 209 IPR001426-1
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 256 - 276 IPR001426-2
domain Sterile alpha motif domain 926 - 993 IPR001660
domain Fibronectin type III 342 - 452 IPR003961-1
domain Fibronectin type III 453 - 548 IPR003961-2
active_site Tyrosine-protein kinase, active site 758 - 770 IPR008266
domain Tyrosine-protein kinase ephrin type A/B receptor-like 274 - 309 IPR011641
binding_site Protein kinase, ATP binding site 643 - 669 IPR017441
domain Tyrosine-protein kinase, catalytic domain 637 - 896 IPR020635
domain Ephrin receptor, transmembrane domain 562 - 634 IPR027936

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q24210 CASK Peripheral plasma membrane protein CASK Drosophila melanogaster (Fruit fly) SS
Q00013 MPP1 55 kDa erythrocyte membrane protein Homo sapiens (Human) PR
O14936 CASK Peripheral plasma membrane protein CASK Homo sapiens (Human) EV
Q96JB8 MPP4 MAGUK p55 subfamily member 4 Homo sapiens (Human) PR
Q14168 MPP2 MAGUK p55 subfamily member 2 Homo sapiens (Human) PR
Q9NZW5 PALS2 Protein PALS2 Homo sapiens (Human) PR
P70290 Mpp1 55 kDa erythrocyte membrane protein Mus musculus (Mouse) PR
O70589 Cask Peripheral plasma membrane protein CASK Mus musculus (Mouse) SS
Q9WV34 Mpp2 MAGUK p55 subfamily member 2 Mus musculus (Mouse) PR
Q6P7F1 Mpp4 MAGUK p55 subfamily member 4 Mus musculus (Mouse) PR
Q8BVD5 Mpp7 MAGUK p55 subfamily member 7 Mus musculus (Mouse) PR
O88910 Mpp3 MAGUK p55 subfamily member 3 Mus musculus (Mouse) PR
Q9QYH1 Mpp4 MAGUK p55 subfamily member 4 Rattus norvegicus (Rat) PR
P54936 lin-2 Protein lin-2 Caenorhabditis elegans SS
10 20 30 40 50 60
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE AVSDNNLELV
70 80 90 100 110 120
NEILEDITPL ISVDENVAEL VGILKEPHFQ SLLEAHDIVA SKCYDSPPSS PEMNIPSLNN
130 140 150 160 170 180
QLPVDAIRIL GIHKKAGEPL GVTFRVENND LVIARILHGG MIDRQGLLHV GDIIKEVNGH
190 200 210 220 230 240
EVGNNPKELQ ELLKNISGSV TLKILPSYRD TITPQQSYVN MERHPAHVRQ VFVKCHFDYN
250 260 270 280 290 300
PFNDNLIPCK EAGLKFSKGE ILQIVNREDP NWWQASHVKE GGSAGLIPSQ FLEEKRKAFV
310 320 330 340 350 360
RRDWDNSGPF CGTISNKKKK KMMYLTTRNA EFDRHEIQIY EEVAKMPPFQ RKTLVLIGAQ
370 380 390 400 410 420
GVGRRSLKNR FIVLNPARFG TTVPFTSRKP REDEKDGQAY KFVSRSEMEA DIKAGKYLEH
430 440 450 460 470 480
GEYEGNLYGT KIDSILEVVQ TGRTCILDVN PQALKVLRTS EFMPYVVFIA APELETLRAM
490 500 510 520 530 540
HKAVVDAGIT TKLLTDSDLK KTVDESARIQ RAYNHYFDLI IVNDNLDKAF EKLQTAIEKL
550
RMEPQWVPIS WVY