AiPD: Autoinhibited Protein Database

Gene name	Mpp1
Protein name	55 kDa erythrocyte membrane protein
Names	p55, Membrane protein, palmitoylated 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:17524
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-87 (Predicted disordered autoinhibitory region) PR

1-87 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P70290-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389565917	35	T>N	No	EVA
rs257840311	43	T>A	No	EVA
rs239065100	54	A>D	No	EVA
rs3389515055	64	Q>E	No	EVA
rs3389567250	65	E>*	No	EVA
rs3389581565	65	E>G	No	EVA
rs3389575817	68	R>G	No	EVA
rs3389545964	103	G>V	No	EVA
rs3389561562	167	F>L	No	EVA
rs3389570649	202	W>C	No	EVA
rs3389560905	207	V>E	No	EVA
rs3389474069	214	S>Y	No	EVA
rs3389567240	232	A>S	No	EVA
rs242706544	301	G>A	No	EVA
rs228832474	305	H>Q	No	EVA
rs586549660	306	N>K	No	EVA
rs213387070	311	A>V	No	EVA
rs3389566711	327	D>N	No	EVA
rs3389521818	328	G>V	No	EVA
rs3410957440	344	S>*	No	EVA
rs3411069324	348	F>L	No	EVA
rs235747840	351	F>Y	No	EVA
rs3389575735	358	M>I	No	EVA
rs3410957505	382	P>H	No	EVA
rs3389514987	406	G>S	No	EVA
rs3389546011	427	A>G	No	EVA
rs3389546011	427	A>V	No	EVA
rs3389578636	431	D>E	No	EVA
rs3389533541	441	E>D	No	EVA
rs3389558729	448	E>G	No	EVA

Type	Name	Position	InterPro Accession
domain	SH3 domain	158 - 228	IPR001452
domain	PDZ domain	71 - 152	IPR001478
domain	Guanylate kinase-like domain	282 - 451	IPR008144
domain	Guanylate kinase/L-type calcium channel beta subunit	281 - 454	IPR008145
conserved_site	Guanylate kinase, conserved site	317 - 334	IPR020590
domain	MPP1, SH3 domain	162 - 223	IPR035475

		Description
EC Number
Subcellular Localization	Cell membrane ; Lipid-anchor Cell projection, stereocilium	Colocalizes with WHRN at stereocilium tip during hair cell development (PubMed:16829577) Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM) (PubMed:17584769) Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies, and at connecting cilium (CC) (PubMed:17584769) Colocalizes with NF2 in non-myelin-forming Schwann cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
centriolar satellite	A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
cortical cytoskeleton	The portion of the cytoskeleton that lies just beneath the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stereocilium	An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.

Name	Definition
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

Name	Definition
regulation of neutrophil chemotaxis	Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q24210	CASK	Peripheral plasma membrane protein CASK	Drosophila melanogaster (Fruit fly)	SS
Q9NZW5	PALS2	Protein PALS2	Homo sapiens (Human)	PR
O14936	CASK	Peripheral plasma membrane protein CASK	Homo sapiens (Human)	EV
Q96JB8	MPP4	MAGUK p55 subfamily member 4	Homo sapiens (Human)	PR
Q14168	MPP2	MAGUK p55 subfamily member 2	Homo sapiens (Human)	PR
Q00013	MPP1	55 kDa erythrocyte membrane protein	Homo sapiens (Human)	PR
O70589	Cask	Peripheral plasma membrane protein CASK	Mus musculus (Mouse)	SS
Q9JLB0	Pals2	Protein PALS2	Mus musculus (Mouse)	PR
Q9WV34	Mpp2	MAGUK p55 subfamily member 2	Mus musculus (Mouse)	PR
Q6P7F1	Mpp4	MAGUK p55 subfamily member 4	Mus musculus (Mouse)	PR
Q8BVD5	Mpp7	MAGUK p55 subfamily member 7	Mus musculus (Mouse)	PR
O88910	Mpp3	MAGUK p55 subfamily member 3	Mus musculus (Mouse)	PR
Q9QYH1	Mpp4	MAGUK p55 subfamily member 4	Rattus norvegicus (Rat)	PR
P54936	lin-2	Protein lin-2	Caenorhabditis elegans	SS