O88910

PR
Gene name
Mpp3 (Dlgh3)
Protein name
MAGUK p55 subfamily member 3
Names
Discs large homolog 3, Protein MPP3
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-388 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O88910

Entry ID Method Resolution Chain Position Source
AF-O88910-F1 Predicted AlphaFoldDB

No variants for O88910

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O88910

No associated diseases with O88910

10 regional properties for O88910

Type Name Position InterPro Accession
domain SH3 domain 226 - 296 IPR001452
domain PDZ domain 137 - 218 IPR001478
domain L27 domain 6 - 64 IPR004172-1
domain L27 domain 61 - 121 IPR004172-2
domain Guanylate kinase-like domain 385 - 568 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 384 - 568 IPR008145
domain L27 domain, C-terminal 13 - 63 IPR014775-1
domain L27 domain, C-terminal 70 - 120 IPR014775-2
conserved_site Guanylate kinase, conserved site 420 - 437 IPR020590
domain MPP3, SH3 domain 230 - 291 IPR035604

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane
  • Cell membrane
  • Cell junction, adherens junction
  • Localized in apical villi of Mueller glia cells (PubMed:23893895)
  • Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (PubMed:23658188)
  • Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q24210 CASK Peripheral plasma membrane protein CASK Drosophila melanogaster (Fruit fly) SS
Q9NZW5 PALS2 Protein PALS2 Homo sapiens (Human) PR
Q00013 MPP1 55 kDa erythrocyte membrane protein Homo sapiens (Human) PR
O14936 CASK Peripheral plasma membrane protein CASK Homo sapiens (Human) EV
Q96JB8 MPP4 MAGUK p55 subfamily member 4 Homo sapiens (Human) PR
Q14168 MPP2 MAGUK p55 subfamily member 2 Homo sapiens (Human) PR
O70589 Cask Peripheral plasma membrane protein CASK Mus musculus (Mouse) SS
P70290 Mpp1 55 kDa erythrocyte membrane protein Mus musculus (Mouse) PR
Q6P7F1 Mpp4 MAGUK p55 subfamily member 4 Mus musculus (Mouse) PR
Q8BVD5 Mpp7 MAGUK p55 subfamily member 7 Mus musculus (Mouse) PR
Q9JLB0 Pals2 Protein PALS2 Mus musculus (Mouse) PR
Q9WV34 Mpp2 MAGUK p55 subfamily member 2 Mus musculus (Mouse) PR
Q9QYH1 Mpp4 MAGUK p55 subfamily member 4 Rattus norvegicus (Rat) PR
P54936 lin-2 Protein lin-2 Caenorhabditis elegans SS
10 20 30 40 50 60
MPVLSEDSGL HETLALLTSQ LRPDSNHREE MGFLRDVFSE KSLSYLMKIH EKLRYYERQS
70 80 90 100 110 120
PTPVLHSAMA LAEDVMEELQ AASVHSDERE LLQLLSTPHL RAVLMVHDTV AQKNFDPVLP
130 140 150 160 170 180
PLPDNIDEDF EEESVKIVRL VKNKEPLGAT IRRDEHSGAV VVARIMRGGA ADRSGLVHVG
190 200 210 220 230 240
DELREVNGIA VLHKRPDEIS QILAQSQGSI TLKIIPATQE EDRFKDSKVF MRALFHYDPR
250 260 270 280 290 300
EDRAIPCQEA GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKQ FQERRLSYRR
310 320 330 340 350 360
TTGTLPSPQN FKKPPYDQPC DKETCDCDGY FKGHYVAGLR RSFRLGCRER LGGSQEAKVP
370 380 390 400 410 420
TGAESQVLLT YEEVARYQHQ PGERPRLVVL IGSLGAHLHE LKQRVVAEDP QQFAVAVPHT
430 440 450 460 470 480
TRPRKSHERD GVEYHFVSKQ AFEADVHHNK FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL
490 500 510 520 530 540
VDVEPEALRH LRTPEFKPYV IFVKPAIQER RKTPPVSPDS EDIASSLDEQ QQEMAASAAF
550 560
IDQHYGHLID TVLVRQDLQE PAASSELS