Q9JK30
PR
Gene name |
Orc3 (Orc3l) |
Protein name |
Origin recognition complex subunit 3 |
Names |
Origin recognition complex subunit Latheo |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:50793 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JK30
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JK30-F1 | Predicted | AlphaFoldDB |
40 variants for Q9JK30
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs233185934 | 3 | T>S | No | EVA | |
| rs3388676129 | 30 | F>L | No | EVA | |
| rs251083204 | 62 | K>E | No | EVA | |
| rs27788295 | 74 | E>G | No | EVA | |
| rs3388676124 | 150 | D>E | No | EVA | |
| rs3388680082 | 151 | V>A | No | EVA | |
| rs242891375 | 170 | H>N | No | EVA | |
| rs3388656537 | 184 | N>S | No | EVA | |
| rs3388680152 | 197 | V>D | No | EVA | |
| rs3393962703 | 200 | K>* | No | EVA | |
| rs3388656508 | 212 | A>E | No | EVA | |
| rs27788317 | 212 | A>P | No | EVA | |
| rs3388664025 | 214 | G>V | No | EVA | |
| rs3388665157 | 237 | Q>* | No | EVA | |
| rs255543335 | 279 | V>I | No | EVA | |
| rs238786605 | 303 | Q>K | No | EVA | |
| rs3394027105 | 306 | F>C | No | EVA | |
| rs3394119390 | 310 | K>* | No | EVA | |
| rs27788339 | 310 | K>I | No | EVA | |
| rs27788339 | 310 | K>R | No | EVA | |
| rs3394240403 | 365 | S>T | No | EVA | |
| rs3394104649 | 366 | V>F | No | EVA | |
| rs3394147098 | 367 | S>T | No | EVA | |
| rs3394072816 | 368 | Q>H | No | EVA | |
| rs3393840602 | 368 | Q>K | No | EVA | |
| rs3393840627 | 369 | C>* | No | EVA | |
| rs231918781 | 425 | L>F | No | EVA | |
| rs3388673604 | 495 | N>S | No | EVA | |
| rs3388656514 | 515 | K>R | No | EVA | |
| rs254314010 | 519 | D>G | No | EVA | |
| rs3394072862 | 526 | K>L | No | EVA | |
| rs211871265 | 526 | K>Q | No | EVA | |
| rs3388676283 | 594 | L>F | No | EVA | |
| rs3394165716 | 602 | P>L | No | EVA | |
| rs3394116001 | 614 | Y>S | No | EVA | |
| rs3394116005 | 615 | Y>F | No | EVA | |
| rs13467811 | 645 | L>R | No | EVA | |
| rs3388680108 | 648 | N>S | No | EVA | |
| rs3388663985 | 654 | E>K | No | EVA | |
| rs3388678678 | 675 | E>* | No | EVA |
No associated diseases with Q9JK30
3 regional properties for Q9JK30
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| DNA replication preinitiation complex | A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nuclear origin of replication recognition complex | A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. |
| nuclear pre-replicative complex | A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| origin recognition complex | A multisubunit complex that is located at the replication origins of a chromosome. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA replication origin binding | Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| DNA replication initiation | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
| glial cell proliferation | The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. |
| neural precursor cell proliferation | The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. |
| regulation of DNA replication | Any process that modulates the frequency, rate or extent of DNA replication. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHTGPRTMAT | SSVSKGCFVF | KPDFKKRKVF | VPIEDYFNNE | ELDSEDSKLR | FETYSLLWQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MKSETEQLQE | ELNENLFDNL | VDFLQKSHPE | FQKNSRDWGS | QMKFREIPTA | ALILGVNVTD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HDVILRSLTE | TLQNNVTPYV | VSLQAKDCPD | VKHFLQKFTS | QLMDCCVDRH | SKEVTSGKAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKTNYSMDSL | CSWYSAVTQK | ADHKVTIKKR | TASGHWRSPP | VVLILKSMES | FTSKVLQDFI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TISSQHLHEF | PLILIFGIAT | SPVIIHRLLP | HSVSSLLCVE | LFQSLSCEQH | LTVVLDKLLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TPQFPFKLSK | KALQVLTNIF | LYHDFSIQSF | IKGIKLSLLE | HFYSQPLSVL | CCDLSEAKKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VNVFSVSQCE | NIRRLPSFRR | YVENQPLGKQ | VALLTNETFL | KEKTQSLLED | LHVYHINYFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLRCLHNFTS | SLPKYPLGRQ | IRELYCTCLE | KKIWDSEEYK | SALQLLRMLA | KDELVSILQR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CIEVLDSSTE | KQLGNTTQKI | KDFLTQFQNL | DADSKEEEDA | CGSQPKGLQK | TDLYHLQKSL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LEMKELRRTK | KPTKFEMLRE | NVMNFIDNLV | RDYLLPPESQ | PLHEVVYFSA | ANTLREHLNA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| APRIALHTAL | NNPYYYLKNE | ELEGCIPNTA | PDICIAYKLH | LECSLLINLV | DWAEAFATVV |
| 670 | 680 | 690 | 700 | 710 | |
| TAAEKMDANS | TVSEEMSEVI | HARFIRAVSE | LELLGFIKPT | KQKTDHVARL | TWGGC |