Q9JJ69

PR
Gene name
Kcnip2 (Kchip2)
Protein name
Kv channel-interacting protein 2
Names
KChIP2, A-type potassium channel modulatory protein 2, Potassium channel-interacting protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:80906
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9JJ69

Entry ID Method Resolution Chain Position Source
AF-Q9JJ69-F1 Predicted AlphaFoldDB

No variants for Q9JJ69

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9JJ69

No associated diseases with Q9JJ69

1 regional properties for Q9JJ69

Type Name Position InterPro Accession
domain Timeless, N-terminal 37 - 305 IPR006906

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Detected on lipid rafts (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

7 GO annotations of molecular function

Name Definition
A-type (transient outward) potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.
calcium ion binding Binding to a calcium ion (Ca2+).
identical protein binding Binding to an identical protein or proteins.
potassium channel regulator activity Binds to and modulates the activity of a potassium channel.
protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein-containing complex binding Binding to a macromolecular complex.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

5 GO annotations of biological process

Name Definition
clustering of voltage-gated potassium channels The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.
membrane repolarization The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
positive regulation of potassium ion export across plasma membrane Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane.
potassium ion export across plasma membrane The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
regulation of potassium ion transmembrane transport Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NS61 KCNIP2 Kv channel-interacting protein 2 Homo sapiens (Human) PR
Q9QXT8 Kcnip3 Calsenilin Mus musculus (Mouse) PR
Q75KU4 CBL4 Calcineurin B-like protein 4 Oryza sativa subsp japonica (Rice) PR
Q7XC27 CBL1 Calcineurin B-like protein 1 Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MRGQGRKESL SDSRDLDGSY DQLTGHPPGP SKKALKQRFL KLLPCCGPQA LPSVSETLAA
70 80 90 100 110 120
PASLRPHRPR PLDPDSVEDE FELSTVCHRP EGLEQLQEQT KFTRRELQVL YRGFKNECPS
130 140 150 160 170 180
GIVNEENFKQ IYSQFFPQGD SSNYATFLFN AFDTNHDGSV SFEDFVAGLS VILRGTIDDR
190 200 210 220 230 240
LNWAFNLYDL NKDGCITKEE MLDIMKSIYD MMGKYTYPAL REEAPREHVE SFFQKMDRNK
250 260
DGVVTIEEFI ESCQQDENIM RSMQLFDNVI