AiPD: Autoinhibited Protein Database

Q9HCU9

Gene name	BRMS1
Protein name	Breast cancer metastasis-suppressor 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:25855
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-64 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9HCU9

Entry ID	Method	Resolution	Chain	Position	Source
2XUS	X-ray	191 A	A/B	51-98	PDB
4AUV	X-ray	200 A	A/B/C/D/E/F/G/H	51-84	PDB
AF-Q9HCU9-F1	Predicted				AlphaFoldDB

223 variants for Q9HCU9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs772080474 CA6120414	2	P>A		No	ClinGen ExAC gnomAD
rs377244043 CA6120413	2	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs772080474 CA381416280	2	P>T		No	ClinGen ExAC gnomAD
rs1470808451 CA381416257	4	Q>*		No	ClinGen gnomAD
rs201559182 CA6120412	6	P>L		No	ClinGen ExAC gnomAD
rs147378296 CA6120410	7	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA381416198 rs1252012530	8	K>T		No	ClinGen gnomAD
rs1174330106 CA381416164	10	T>K		No	ClinGen TOPMed
CA6120409 rs367827792	12	E>K		No	ClinGen ESP ExAC gnomAD
CA381416120 rs1261772484	13	M>I		No	ClinGen gnomAD
rs1179238080 CA381416094	15	A>T		No	ClinGen TOPMed
CA6120408 rs142767365	15	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs550292191 CA6120407	16	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6120405 rs756789800	19	S>F		No	ClinGen ExAC TOPMed gnomAD
CA381416042 rs1237146051	19	S>P		No	ClinGen gnomAD
TCGA novel	23	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6120404 rs77057703	26	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA6120402 rs138644780	29	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs763888379 CA6120403	29	E>K		No	ClinGen ExAC gnomAD
TCGA novel	32	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752499898 CA6120400	33	E>G		No	ClinGen ExAC gnomAD
CA381415922 rs1454386673	33	E>K		No	ClinGen gnomAD
CA6120399 rs765067003	34	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs759402490 CA6120398	35	S>N		No	ClinGen ExAC gnomAD
rs772166702 CA381415906 CA6120396	35	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1159239724 CA381415905	36	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	36	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381415897 rs1443408319	37	S>C		No	ClinGen gnomAD
CA381415892 rs1590930225	37	S>R		No	ClinGen Ensembl
rs373981694 CA6120395	39	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs768936731 CA381415872	40	E>D		No	ClinGen ExAC TOPMed
CA381415878 rs1462099670	40	E>K		No	ClinGen gnomAD
CA381415868 rs1590930191	41	S>A		No	ClinGen Ensembl
CA381415865 rs1203662570	41	S>L		No	ClinGen gnomAD
CA381415860 rs1555015522	42	E>G		No	ClinGen Ensembl
rs1555015522 CA6120390	42	E>V		No	ClinGen Ensembl
CA381415857 rs1486984957	43	E>K		No	ClinGen gnomAD
rs1565207072 CA381415834	45	S>R		No	ClinGen Ensembl
CA224039984 rs952363758	46	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs746394925 CA6120386	47	E>K		No	ClinGen ExAC TOPMed gnomAD
rs746394925 CA6120387	47	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs920915897 CA381415810	48	M>L		No	ClinGen gnomAD
CA224039572 rs920915897	48	M>V		No	ClinGen gnomAD
CA381415800 rs1271273660	49	D>G		No	ClinGen gnomAD
rs757857414 CA6120348	49	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA381415786 rs1200243088	51	E>K		No	ClinGen TOPMed gnomAD
CA6120347 rs747784176	52	D>H		No	ClinGen ExAC gnomAD
CA381415504 rs747784176	52	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1272276930 CA381415474	53	Y>C		No	ClinGen gnomAD
rs1194003067 CA381415466	54	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1194003067 CA381415464	54	E>Q		No	ClinGen TOPMed gnomAD
rs778576158 CA6120346	55	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA224039542 rs773322973	55	R>Q		No	ClinGen gnomAD
CA381415440 rs1222620698	56	R>C		No	ClinGen gnomAD
CA6120345 rs374621425	56	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1222620698 CA381415443	56	R>S		No	ClinGen gnomAD
CA6120344 rs753669865	57	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1405043961 CA381415427	57	R>H		No	ClinGen TOPMed gnomAD
CA381415420 rs1334646656	58	S>N		No	ClinGen gnomAD
rs201834097 CA224039518	59	E>K		No	ClinGen 1000Genomes
CA224039512 rs756063796	60	C>S		No	ClinGen ExAC gnomAD
rs756063796 CA6120342	60	C>Y		No	ClinGen ExAC gnomAD
rs750296700 CA6120341	61	V>F		No	ClinGen ExAC gnomAD
CA381415366 rs1197280476	62	S>N		No	ClinGen TOPMed
CA381415357 rs1429183916	63	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA224039507 rs1005335041	64	M>I		No	ClinGen TOPMed
rs1431736990 CA381415300	67	L>V		No	ClinGen gnomAD
TCGA novel	68	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6120336 rs759834920	70	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA6120335 rs777193514	72	S>L		No	ClinGen ExAC TOPMed gnomAD
rs773727934 CA6120332	77	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1426313088 CA381415063	80	R>T		No	ClinGen TOPMed
CA381415054 rs1156674553	81	E>*		No	ClinGen TOPMed
CA224039323 COSM329054 COSM1317274 rs777309913	82	R>*	liver haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6120308 rs779635935	82	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA381415033 rs1430406662	83	L>V		No	ClinGen gnomAD
CA6120306 rs745705747	84	S>T		No	ClinGen ExAC TOPMed gnomAD
CA6120303 rs751394775	87	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs757278464 CA6120304	87	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1590929151 CA381414990	88	L>V		No	ClinGen Ensembl
rs564172836 CA6120301	89	R>L		No	ClinGen ExAC TOPMed gnomAD
rs564172836 CA381414983	89	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6120302 rs367854116	89	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs199933125 CA6120299	91	E>G		No	ClinGen ExAC gnomAD
CA381414951 rs1240059703	92	E>G		No	ClinGen gnomAD
rs760946811 CA381414933	93	V>A		No	ClinGen ExAC gnomAD
CA6120298 rs760946811	93	V>G		No	ClinGen ExAC gnomAD
CA6120296 rs767755816	95	A>T		No	ClinGen ExAC gnomAD
CA381414910 rs1219564175	95	A>V		No	ClinGen gnomAD
TCGA novel	97	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774685217 CA6120294	98	A>D		No	ClinGen ExAC gnomAD
COSM1585938 CA6120292 COSM930718 rs762502004	102	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1400803460 CA381414795	104	P>T		No	ClinGen TOPMed gnomAD
rs774951857 CA6120291	105	L>P		No	ClinGen ExAC gnomAD
rs374007540 CA381414772	106	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA224039209 rs1027722053	106	G>R		No	ClinGen TOPMed gnomAD
rs374007540 CA6120290	106	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA381414773 rs1027722053	106	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6120288 rs148062689	107	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA381414762 rs148062689	107	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6120289 rs745495658	107	G>W		No	ClinGen ExAC gnomAD
CA224039191 rs894284057	108	L>R		No	ClinGen TOPMed
rs746996980 CA6120285	110	R>Q		No	ClinGen ExAC gnomAD
CA381414731 rs1357422997	110	R>W		No	ClinGen TOPMed
CA6120284 CA381414712 rs371890921	111	S>R		No	ClinGen ESP ExAC gnomAD
CA6120283 rs758384368	113	K>R		No	ClinGen ExAC TOPMed gnomAD
rs749417187 CA6120282	115	R>C		No	ClinGen ExAC TOPMed gnomAD
CA381414670 rs749417187	115	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM930717 CA6120281 rs541164374 COSM1585939	115	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA381414669 rs541164374	115	R>L		No	ClinGen ExAC gnomAD
CA381414666 rs1444163017	116	I>V		No	ClinGen TOPMed
rs1565206314 CA381414658	117	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA381414598 rs764756155	120	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6120253 rs764756155	120	G>E		No	ClinGen ExAC TOPMed gnomAD
COSM1184945 rs1483720530 CA381414592 COSM1184946	121	I>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA224038975 rs758921033	122	Y>C		No	ClinGen ExAC gnomAD
rs758921033 CA6120252	122	Y>F		No	ClinGen ExAC gnomAD
CA6120251 rs776182648	123	K>E		No	ClinGen ExAC gnomAD
rs186635131 CA6120250	125	F>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6120249 rs186635131	125	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771932823 CA6120247	126	C>S		No	ClinGen ExAC gnomAD
rs748130658 CA6120246	127	L>P		No	ClinGen ExAC
rs1467750038 CA381414508	127	L>V		No	ClinGen TOPMed gnomAD
rs1419719115 CA381414492	128	D>G		No	ClinGen TOPMed
rs1590928762 CA381414477	129	V>E		No	ClinGen Ensembl
CA381414455 rs550479193	131	R>S		No	ClinGen TOPMed gnomAD
rs1312673283 CA381414443	132	N>S		No	ClinGen gnomAD
rs753783270 CA381414404	134	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA381414408 rs1304273905	134	Y>C		No	ClinGen TOPMed
rs1404777582 CA381414414	134	Y>H		No	ClinGen TOPMed
COSM194375 rs768620232 CA6120244	135	E>K	Variant assessed as Somatic; 4.634e-05 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA381414378 rs1287910736	136	C>Y		No	ClinGen TOPMed gnomAD
rs1444589958 CA381414303	142	K>E		No	ClinGen gnomAD
CA6120242 rs781328384	143	Q>*		No	ClinGen ExAC gnomAD
rs781328384 CA6120243	143	Q>E		No	ClinGen ExAC gnomAD
CA381414276 rs1590928715	144	H>Y		No	ClinGen Ensembl
rs1034218751 CA224038930	146	E>K		No	ClinGen TOPMed
rs1287724284 CA381414198	147	S>G		No	ClinGen gnomAD
TCGA novel	148	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6120221 rs371712796	153	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6120220 rs201498177	155	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779327411 CA6120218	156	L>V		No	ClinGen ExAC gnomAD
TCGA novel	157	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755492023 CA6120217	158	G>R		No	ClinGen ExAC TOPMed gnomAD
CA224038813 rs375028792	159	E>*		No	ClinGen Ensembl
rs370788997 CA224038810	159	E>V		No	ClinGen Ensembl
CA381414111 rs1590928543	160	L>R		No	ClinGen Ensembl
rs116853990 CA6120216	162	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140338984 CA6120213	163	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1585941 rs140338984 CA6120212 COSM930715	163	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs755639797 CA6120214	163	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1424621566 CA381414083	165	Q>R		No	ClinGen TOPMed gnomAD
rs1171161107 CA381414076	166	R>K		No	ClinGen gnomAD
CA381414062 rs1590928504	168	E>G		No	ClinGen Ensembl
CA381414054 rs1590928492	169	E>G		No	ClinGen Ensembl
CA6120210 rs751370154	171	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200013073 CA6120209	171	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1248505855 CA381414035	172	Q>P		No	ClinGen gnomAD
rs1248505855 CA381414034	172	Q>R		No	ClinGen gnomAD
CA381414023 rs1590928470	173	S>R		No	ClinGen Ensembl
CA6120208 rs762805402	174	L>P		No	ClinGen ExAC TOPMed gnomAD
rs770936650 CA6120206	176	L>F		No	ClinGen ExAC gnomAD
CA6120205 rs200297342	178	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs575951728 CA224038767	179	E>K		No	ClinGen gnomAD
rs1011825577 CA224038515	180	W>C		No	ClinGen TOPMed gnomAD
rs865948521 CA224038509	181	W>L		No	ClinGen Ensembl
CA381413957 rs1238903687	182	D>N		No	ClinGen gnomAD
rs141305456 CA6120178	183	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1283289155 CA381413938	184	K>R		No	ClinGen gnomAD
CA381413933 rs1468869031	185	L>V		No	ClinGen TOPMed
rs1355055805 CA381413925	186	H>P		No	ClinGen TOPMed gnomAD
CA6120174 rs746664615	187	A>D		No	ClinGen ExAC gnomAD
CA6120175 rs756789967	187	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA224038500 rs746664615	187	A>V		No	ClinGen ExAC gnomAD
rs1285050200 CA381413916	188	R>K		No	ClinGen gnomAD
rs777528665 CA381413901	190	S>I		No	ClinGen ExAC TOPMed gnomAD
CA6120173 rs777528665	190	S>T		No	ClinGen ExAC TOPMed gnomAD
rs531419407 CA6120172	191	S>C		No	ClinGen 1000Genomes ExAC gnomAD
CA381413887 rs752604361	192	R>S		No	ClinGen ExAC gnomAD
rs1590927939 CA381413884	193	S>A		No	ClinGen Ensembl
rs1162834471 CA381413874	194	W>*		No	ClinGen gnomAD
CA381413878 rs1420310752	194	W>G		No	ClinGen gnomAD
rs1361103229 CA381413875	194	W>L		No	ClinGen gnomAD
rs946541304 CA224038497	198	P>L		No	ClinGen gnomAD
CA381413797 rs1260509548	205	A>V		No	ClinGen gnomAD
CA6120165 rs774267037	206	P>L		No	ClinGen ExAC gnomAD
rs369071599 CA6120166	206	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6120136 rs778485062	210	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1438269187 CA381413755	211	P>S		No	ClinGen gnomAD
CA381413750 rs1255115164	212	Y>H		No	ClinGen TOPMed
rs201158226 CA224038137	213	I>M		No	ClinGen ExAC TOPMed gnomAD
CA6120134 rs749150566	213	I>V		No	ClinGen ExAC gnomAD
rs199579517 CA224038130	214	V>L		No	ClinGen Ensembl
rs199579517 CA224038133	214	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA381413722 rs1212409210	216	M>T		No	ClinGen TOPMed gnomAD
rs1254427890 CA381413724	216	M>V		No	ClinGen TOPMed gnomAD
rs1312843824 CA381413707	218	Q>R		No	ClinGen gnomAD
CA6120131 rs750265527	219	E>G		No	ClinGen ExAC
CA6120129 rs758361866	221	D>N		No	ClinGen ExAC gnomAD
rs752803795 CA6120128	222	I>V		No	ClinGen ExAC
CA381413671 rs1447158738	224	E>K		No	ClinGen gnomAD
rs765597819 CA6120127	225	D>V		No	ClinGen ExAC gnomAD
CA381413655 rs1197006278	226	W>R		No	ClinGen TOPMed
CA381413647 rs1590926621	227	T>P		No	ClinGen Ensembl
CA6120126 rs759825542	229	I>T		No	ClinGen ExAC gnomAD
CA6120124 rs544134195	230	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6120123 rs761244905	231	K>R		No	ClinGen ExAC gnomAD
TCGA novel	231	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381413600 rs1218172694	233	R>G		No	ClinGen gnomAD
rs758905839 CA224037943	234	A>S		No	ClinGen ExAC gnomAD
CA6120061 rs758905839	234	A>T		No	ClinGen ExAC gnomAD
CA6120060 rs149983593	235	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1432837451 CA381413585	235	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6120059 rs548623692	236	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA381413574 rs1415586092	237	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs972722443 CA381413572	238	P>A		No	ClinGen TOPMed gnomAD
CA224037924 rs1008119943	238	P>R		No	ClinGen Ensembl
rs972722443 CA224037926	238	P>S		No	ClinGen TOPMed gnomAD
COSM1356180 CA381413534 rs1420865742 COSM930714	243	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA6120057 rs753485547	243	S>P		No	ClinGen ExAC gnomAD
CA224037920 rs1030988735	244	D>N		No	ClinGen Ensembl
CA381413529 rs1287094732	244	D>V		No	ClinGen TOPMed
CA6120037 rs750299317	246	P>S		No	ClinGen ExAC

No associated diseases with Q9HCU9

No regional properties for Q9HCU9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9HCU9

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Predominantly nuclear
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Sin3 complex	A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
Sin3-type complex	Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.

2 GO annotations of molecular function

Name	Definition
histone deacetylase binding	Binding to histone deacetylase.
NF-kappaB binding	Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.

12 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
histone deacetylation	The modification of histones by removal of acetyl groups.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of NF-kappaB transcription factor activity	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
negative regulation of stem cell population maintenance	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transforming growth factor beta receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
positive regulation of anoikis	Any process that activates or increases the frequency, rate or extent of anoikis.
positive regulation of protein deacetylation	Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
positive regulation of stem cell population maintenance	Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9H7L9	SUDS3	Sin3 histone deacetylase corepressor complex component SDS3	Homo sapiens (Human)	PR
A4II71	brms1l	Breast cancer metastasis-suppressor 1-like protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MPVQPPSKDT	EEMEAEGDSA	AEMNGEEEES	EEERSGSQTE	SEEESSEMDD	EDYERRRSEC
70	80	90	100	110	120
VSEMLDLEKQ	FSELKEKLFR	ERLSQLRLRL	EEVGAERAPE	YTEPLGGLQR	SLKIRIQVAG
130	140	150	160	170	180
IYKGFCLDVI	RNKYECELQG	AKQHLESEKL	LLYDTLQGEL	QERIQRLEED	RQSLDLSSEW
190	200	210	220	230	240
WDDKLHARGS	SRSWDSLPPS	KRKKAPLVSG	PYIVYMLQEI	DILEDWTAIK	KARAAVSPQK

RKSDGP