A4II71

PR
Gene name
brms1l
Protein name
Breast cancer metastasis-suppressor 1-like protein
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100124958
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-284 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4II71

Entry ID Method Resolution Chain Position Source
AF-A4II71-F1 Predicted AlphaFoldDB

No variants for A4II71

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4II71

No associated diseases with A4II71

No regional properties for A4II71

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A4II71

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
Sin3-type complex Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.

1 GO annotations of molecular function

Name Definition
histone deacetylase binding Binding to histone deacetylase.

2 GO annotations of biological process

Name Definition
histone deacetylation The modification of histones by removal of acetyl groups.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HCU9 BRMS1 Breast cancer metastasis-suppressor 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MPVHSREKKE SNHNDMEVDY PENEGTSSEE DDSDSSSGSE EGDSSEMDDE DCERRRMECL
70 80 90 100 110 120
DEMSNLEKQF TDLKDQLYKE RLSQVDAKLQ EVIAGKAPEY LEPLANLQEN MQIRTKVAGI
130 140 150 160 170 180
YRELCLESVK NKHDCEIQAA RQHCESEKLL LYDTVQSELE EKIRRLEEDR HSIDITSELW
190 200 210 220 230 240
NDELQSRRKR KDPFSPDKKK KPVVVSGPYI VYMLQDLDIL EDWTTIRKAM ASFGPHRVKP
250 260 270 280 290 300
EVTVKMEKHQ HSARSEEGRL HYDGEWYGRG QTICIDKKDE FPTSAVITTI NSDEVWFKRQ
310 320
DGSKSKLYIS QLQKGKYSIK HI