AiPD: Autoinhibited Protein Database

Q9H7L9

Gene name	SUDS3 (SAP45, SDS3)
Protein name	Sin3 histone deacetylase corepressor complex component SDS3
Names	45 kDa Sin3-associated polypeptide, Suppressor of defective silencing 3 protein homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64426
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-117 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-117 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9H7L9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9H7L9-F1	Predicted				AlphaFoldDB

220 variants for Q9H7L9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746669779 CA6818517	4	A>S		No	ClinGen ExAC gnomAD
rs746669779 CA386617191	4	A>T		No	ClinGen ExAC gnomAD
CA386617193 rs1479982907	4	A>V		No	ClinGen gnomAD
CA6818518 rs768250848	6	L>M		No	ClinGen ExAC gnomAD
rs1593744291 CA386617205	6	L>R		No	ClinGen Ensembl
rs1310294591 CA386617209	7	L>P		No	ClinGen TOPMed
CA386617208 rs1310294591	7	L>R		No	ClinGen TOPMed
CA386617216 rs1162017222	8	A>V		No	ClinGen gnomAD
rs780697128 CA6818521	9	P>S		No	ClinGen ExAC gnomAD
rs747666799 CA6818522	10	A>T		No	ClinGen ExAC gnomAD
CA386617226 rs1328345350	10	A>V		No	ClinGen gnomAD
rs1566193084 CA386617230	11	P>Q		No	ClinGen Ensembl
rs563028233 CA6818523	14	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs760160171 CA6818525	16	A>V		No	ClinGen ExAC TOPMed gnomAD
CA386617266 rs1243530400	17	P>Q		No	ClinGen TOPMed gnomAD
CA386617267 rs1243530400	17	P>R		No	ClinGen TOPMed gnomAD
CA386617265 rs1381897547	17	P>S		No	ClinGen gnomAD
CA386617278 rs772479705	19	A>D		No	ClinGen ExAC TOPMed gnomAD
CA386617279 rs772479705	19	A>G		No	ClinGen ExAC TOPMed gnomAD
CA6818526 rs772479705	19	A>V		No	ClinGen ExAC TOPMed gnomAD
CA244288137 rs544700850	20	P>L		No	ClinGen 1000Genomes
rs1188164097 CA386617291	21	E>D		No	ClinGen TOPMed
rs1198656930 CA386617289	21	E>G		No	ClinGen gnomAD
rs866966874 CA244288143	23	Y>*		No	ClinGen Ensembl
rs1239356525 CA386617313	24	P>R		No	ClinGen gnomAD
CA386617330 rs1182171859	27	D>N		No	ClinGen gnomAD
rs1358943164 CA386617351	29	E>V		No	ClinGen gnomAD
rs892087195 CA244288152	31	E>D		No	ClinGen TOPMed gnomAD
rs764224525 CA6818529	31	E>K		No	ClinGen ExAC gnomAD
CA6818530 rs753872124	32	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1411757672 CA386617370	32	S>R		No	ClinGen gnomAD
CA386617404 rs1405327969	37	E>K		No	ClinGen TOPMed gnomAD
CA386617432 rs1340831627	41	R>G		No	ClinGen TOPMed gnomAD
rs1045838087 CA244288163	41	R>L		No	ClinGen TOPMed
CA386617434 rs1045838087	41	R>Q		No	ClinGen TOPMed
rs1053744960 CA244288168	42	G>V		No	ClinGen TOPMed
rs1268054154 CA386617444	43	R>H		No	ClinGen gnomAD
rs765352402 CA6818532	45	S>W		No	ClinGen ExAC gnomAD
CA386617466 rs1403316498	46	D>E		No	ClinGen TOPMed
rs1261929353 CA386617464	46	D>G		No	ClinGen TOPMed gnomAD
rs1218735000 CA386617461	46	D>N		No	ClinGen TOPMed gnomAD
rs1261929353 CA386617465	46	D>V		No	ClinGen TOPMed gnomAD
rs1412409740 CA386617478	48	D>N		No	ClinGen TOPMed
rs773338440 CA6818551	52	A>T		No	ClinGen ExAC gnomAD
rs1362202212 CA386615165	57	L>V		No	ClinGen gnomAD
CA386615170 rs1566195001	58	A>P		No	ClinGen Ensembl
rs766233481 CA6818554	60	H>R		No	ClinGen ExAC gnomAD
rs1162927693 CA386615193	61	D>G		No	ClinGen TOPMed
rs751330932 CA6818555	61	D>H		No	ClinGen ExAC gnomAD
rs767458289 CA6818557	62	E>K		No	ClinGen ExAC gnomAD
CA386615210 rs1332219006	63	E>D		No	ClinGen gnomAD
CA386615216 rs1391280323	64	D>V		No	ClinGen TOPMed gnomAD
rs752392988 CA6818558	64	D>Y		No	ClinGen ExAC gnomAD
rs181326809 CA6818560	65	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA386615230 rs1342574606	66	V>A		No	ClinGen gnomAD
TCGA novel	67	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6818562 rs748749200	68	M>V		No	ClinGen ExAC gnomAD
rs1449318119	70	E>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6818564 rs780445182	70	E>A		No	ClinGen ExAC gnomAD
rs1268137527 CA386615267	71	Q>P		No	ClinGen TOPMed gnomAD
rs1268137527 CA386615268	71	Q>R		No	ClinGen TOPMed gnomAD
CA6818587 rs756702598	72	M>I		No	ClinGen ExAC gnomAD
rs1593754330 CA386615284	72	M>V		No	ClinGen Ensembl
rs778528923 CA6818588	73	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA244291175 rs1014473502	74	Q>R		No	ClinGen TOPMed
CA244291180 rs998007936	75	D>E		No	ClinGen Ensembl
CA244291178 rs1036369847	75	D>G		No	ClinGen TOPMed gnomAD
rs752009155 CA6818589	75	D>N		No	ClinGen ExAC gnomAD
rs755541953 CA6818591	78	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6818590 rs755541953	78	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6818592 rs748517926	82	R>G		No	ClinGen ExAC gnomAD
CA6818593 rs769964804	83	Q>E		No	ClinGen ExAC gnomAD
rs777881792 CA6818594	83	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs202206050 CA244291187	83	Q>R		No	ClinGen 1000Genomes
rs770909945 CA6818596	85	Q>E		No	ClinGen ExAC gnomAD
CA244291662 rs528980447	93	Q>*		No	ClinGen Ensembl
rs756437913 CA6818611	94	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1484729381 CA386615446	95	Y>H		No	ClinGen gnomAD
CA386615453 rs1218353024	96	Q>K		No	ClinGen gnomAD
rs1263363417 CA386615488	100	K>R		No	ClinGen gnomAD
TCGA novel	102	L>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386615537 rs1479840725	106	Y>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1240738725 CA386615542	107	K>R		No	ClinGen TOPMed
CA386615556 rs1187515448	109	R>K		No	ClinGen TOPMed
CA386615570 rs1423741028	111	R>Q		No	ClinGen TOPMed gnomAD
CA6818612 rs778267106	111	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6818613 rs749457609	113	A>T		No	ClinGen ExAC gnomAD
rs201143743 CA6818625	114	E>A		No	ClinGen ExAC TOPMed gnomAD
CA244292567 rs201143743	114	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	114	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244292854 rs984721833	121	T>A		No	ClinGen TOPMed
CA386615681 rs1174175836	124	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA386615679 rs1174175836	124	V>M		No	ClinGen TOPMed gnomAD
CA6818680 rs749109444	125	E>D		No	ClinGen ExAC gnomAD
rs770521321 CA6818681	126	R>*		No	ClinGen ExAC gnomAD
rs778513849 CA6818682 COSM1227978	126	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs745546784 CA6818683	127	N>Y		No	ClinGen ExAC gnomAD
rs910638387 CA244292862	128	Y>*		No	ClinGen TOPMed
rs372566624 CA6818684	129	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386615710 rs1169919465	129	I>V		No	ClinGen TOPMed
TCGA novel	131	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774922551 CA6818685	131	E>G		No	ClinGen ExAC gnomAD
TCGA novel	131	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386615757 rs1246273218	135	A>V		No	ClinGen TOPMed
rs770430497 CA6818687	141	D>N		No	ClinGen ExAC TOPMed gnomAD
CA386615812 rs1284174474	143	K>E		No	ClinGen gnomAD
CA386615819 rs1236913555	144	V>I		No	ClinGen TOPMed
TCGA novel	148	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766902385 CA6818690	148	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	148	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369923125 CA6818692	152	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA386615878 rs1217179309	153	E>K		No	ClinGen TOPMed
rs373116917 CA6818693	155	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA386615891 rs373116917	155	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA244292878 rs201081140	158	K>R		No	ClinGen 1000Genomes
rs756035632 CA6818695 CA386615935	160	M>I		No	ClinGen ExAC TOPMed gnomAD
CA6818694 rs752720503	160	M>V		No	ClinGen ExAC gnomAD
CA386615958 rs1442492517	163	N>K		No	ClinGen TOPMed
CA386615993 rs1442631323	168	M>I		No	ClinGen TOPMed
CA6818697 rs753821236	168	M>V		No	ClinGen ExAC TOPMed gnomAD
CA386616013 rs1356118967	171	T>S		No	ClinGen TOPMed
rs1387963971 CA386616019	172	G>A		No	ClinGen gnomAD
CA386616041 rs1291761178	173	D>E		No	ClinGen TOPMed
rs988586329 CA244295316	174	S>C		No	ClinGen TOPMed
CA6818725 rs754510487	175	M>T		No	ClinGen ExAC gnomAD
CA386616063 rs1196682353	177	V>M		No	ClinGen gnomAD
rs1308781359 CA386616140	188	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	192	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6818728 COSM1586193 rs771567083	193	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1422281395 CA386616200	197	D>G		No	ClinGen gnomAD
CA6818729 rs774735602	198	K>R		No	ClinGen ExAC gnomAD
TCGA novel	199	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775544200 CA6818732	202	P>T		No	ClinGen ExAC gnomAD
rs760954042 CA6818733	204	P>S		No	ClinGen ExAC gnomAD
rs1049843436 CA244295682 COSM3710693	205	A>V	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA386616326 rs1362645207	213	D>V		No	ClinGen gnomAD
rs1386137210 CA386616350	216	I>S		No	ClinGen gnomAD
CA386616373 rs1206126731	219	D>G		No	ClinGen TOPMed
TCGA novel	220	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6818749 rs746426545	221	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6818768 rs758955835	226	L>V		No	ClinGen ExAC TOPMed gnomAD
CA244295784 rs374831127	227	K>R		No	ClinGen ESP TOPMed
CA244295786 rs199697453	228	S>P		No	ClinGen 1000Genomes
CA386616456 rs1189790588	230	K>R		No	ClinGen TOPMed
CA386616467 rs747407587	232	P>A		No	ClinGen ExAC gnomAD
rs768818165 CA6818771	232	P>L		No	ClinGen ExAC gnomAD
rs747407587 CA6818770	232	P>S		No	ClinGen ExAC gnomAD
rs771181051 CA6818794	235	P>A		No	ClinGen ExAC gnomAD
CA244296384 rs1000183597	236	S>P		No	ClinGen TOPMed
TCGA novel	239	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6818795 rs774395545	239	E>K		No	ClinGen ExAC TOPMed gnomAD
rs774395545 CA386616516	239	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA6818796 rs745864666	242	P>L		No	ClinGen ExAC
rs1168352037 CA386616540	242	P>S		No	ClinGen TOPMed gnomAD
COSM3980806 rs1168352037 CA386616538	242	P>T	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs771978157 CA6818797	243	A>T		No	ClinGen ExAC gnomAD
rs538334959 CA6818799	246	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6818800 rs763836948	246	A>V		No	ClinGen ExAC TOPMed gnomAD
CA386616567 rs1295784045	247	E>A		No	ClinGen gnomAD
rs1339163832 CA386616577 COSM3811177	248	S>F	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6818803 rs764768024	249	P>L		No	ClinGen ExAC gnomAD
CA386616579 rs1433495669	249	P>S		No	ClinGen gnomAD
CA386616583 rs942554767	250	A>P		No	ClinGen TOPMed gnomAD
rs942554767 CA244296414	250	A>T		No	ClinGen TOPMed gnomAD
rs112917165 CA244296419	250	A>V		No	ClinGen gnomAD
rs370809170 CA6818804	251	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs767815527 CA6818806	253	F>S		No	ClinGen ExAC gnomAD
CA6818807 rs753113225	254	E>Q		No	ClinGen ExAC gnomAD
CA6818809 rs373198095	256	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	256	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6818810 rs749510680	257	I>M		No	ClinGen ExAC gnomAD
CA386616644 rs1476935882	259	D>V		No	ClinGen gnomAD
rs370306899 CA6818812 COSM1586192	260	G>D	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs370306899 CA244296448	260	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6818813 rs750399686	261	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	265	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1400738595 CA386616692	266	K>R		No	ClinGen gnomAD
CA386616727 rs1307387363	268	W>C		No	ClinGen gnomAD
rs1239919523 CA386616734	269	Y>*		No	ClinGen gnomAD
rs370035802 CA244300108	269	Y>C		No	ClinGen gnomAD
rs1283657392 CA386616738	270	H>Y		No	ClinGen gnomAD
rs764428907 CA6818828	273	Q>*		No	ClinGen ExAC gnomAD
rs1273669257 CA386616767	274	A>T		No	ClinGen gnomAD
rs754074028 CA6818829	274	A>V		No	ClinGen ExAC gnomAD
TCGA novel	275	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757566130 CA6818830	276	Y>S		No	ClinGen ExAC gnomAD
rs1328220842 CA386616795	278	E>G		No	ClinGen TOPMed
CA386616806 rs1381811005	280	K>E		No	ClinGen gnomAD
rs773992339 CA244300121	281	D>A		No	ClinGen Ensembl
rs779069152 CA6818831	281	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1438034266 CA386616823	282	N>S		No	ClinGen gnomAD
rs879223193 CA244300126	288	V>M		No	ClinGen Ensembl
CA386616875 rs1426471996	289	I>M		No	ClinGen TOPMed
rs1366210205 CA386616877	290	S>G		No	ClinGen gnomAD
CA386616881 rs1475869831	290	S>N		No	ClinGen gnomAD
rs370752292 CA6818833	295	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386616942 rs367623642	297	I>M		No	ClinGen ESP TOPMed gnomAD
TCGA novel	297	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	302	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1339838516 CA386616983	303	S>T		No	ClinGen TOPMed gnomAD
TCGA novel	305	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	309	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386617043 rs1407132256	311	Y>C		No	ClinGen TOPMed
rs1307883445 CA386617077	316	Q>R		No	ClinGen gnomAD
rs1471032611 CA386617083	317	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	321	V>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765577252 CA386617121	323	R>C		No	ClinGen ExAC gnomAD
rs1284678288 CA386617122	323	R>H		No	ClinGen gnomAD
rs765577252 CA6818851	323	R>S		No	ClinGen ExAC gnomAD
rs1486981513 CA386617127	324	R>Q		No	ClinGen TOPMed gnomAD
CA386617126 rs1281071207	324	R>W		No	ClinGen TOPMed
CA386617132 rs1185298509	325	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386617135 rs1593789619	325	R>H		No	ClinGen Ensembl
TCGA novel	326	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	326	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	327	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750724463 CA244301550	329	A>G		No	ClinGen ExAC TOPMed gnomAD
CA6818852 rs750724463	329	A>R		No	ClinGen ExAC TOPMed gnomAD
rs1224739484 CA386617155	329	A>S		No	ClinGen TOPMed

No associated diseases with Q9H7L9

No regional properties for Q9H7L9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9H7L9

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Sin3 complex	A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
Sin3-type complex	Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.

2 GO annotations of molecular function

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
histone deacetylase binding	Binding to histone deacetylase.

11 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone deacetylation	The modification of histones by removal of acetyl groups.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of stem cell population maintenance	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transforming growth factor beta receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of stem cell population maintenance	Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
substantia nigra development	The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9HCU9	BRMS1	Breast cancer metastasis-suppressor 1	Homo sapiens (Human)	PR
Q8BR65	Suds3	Sin3 histone deacetylase corepressor complex component SDS3	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSAAGLLAPA	PAQAGAPPAP	EYYPEEDEEL	ESAEDDERSC	RGRESDEDTE	DASETDLAKH
70	80	90	100	110	120
DEEDYVEMKE	QMYQDKLASL	KRQLQQLQEG	TLQEYQKRMK	KLDQQYKERI	RNAELFLQLE
130	140	150	160	170	180
TEQVERNYIK	EKKAAVKEFE	DKKVELKENL	IAELEEKKKM	IENEKLTMEL	TGDSMEVKPI
190	200	210	220	230	240
MTRKLRRRPN	DPVPIPDKRR	KPAPAQLNYL	LTDEQIMEDL	RTLNKLKSPK	RPASPSSPEH
250	260	270	280	290	300
LPATPAESPA	QRFEARIEDG	KLYYDKRWYH	KSQAIYLESK	DNQKLSCVIS	SVGANEIWVR
310	320
KTSDSTKMRI	YLGQLQRGLF	VIRRRSAA