AiPD: Autoinhibited Protein Database

Q9HBK9

Gene name	AS3MT (CYT19)
Protein name	Arsenite methyltransferase
Names	Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57412
EC number	2.1.1.137: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

320-375 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

320-375 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9HBK9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9HBK9-F1	Predicted				AlphaFoldDB

267 variants for Q9HBK9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs773603561 CA5669874	3	A>G		No	ClinGen ExAC TOPMed gnomAD
rs368195232 CA5669875	6	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA377941997 rs1216089695	9	I>L		No	ClinGen gnomAD
rs774957352 CA5669878	10	Q>*		No	ClinGen ExAC gnomAD
rs774957352 CA5669877	10	Q>K		No	ClinGen ExAC gnomAD
CA377942020 rs1176168625	12	D>G		No	ClinGen gnomAD
CA5669880 rs763634134	14	Q>H		No	ClinGen ExAC gnomAD
CA377942049 rs1308736476	15	T>A		No	ClinGen gnomAD
CA377942050 rs1308736476	15	T>S		No	ClinGen gnomAD
CA377942076 rs1460423938	19	Q>K		No	ClinGen TOPMed
CA377942084 rs1406708151	20	V>M		No	ClinGen TOPMed gnomAD
CA5669902 rs372675994	23	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA5669904 rs766934575	25	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1189640899 CA377942120	26	D>N		No	ClinGen TOPMed gnomAD
rs1435271717 CA377942128	27	L>I		No	ClinGen gnomAD
rs1237767710 CA377942131	27	L>R		No	ClinGen gnomAD
rs1317257468 CA377942143	29	T>A		No	ClinGen TOPMed
rs1184690622 CA377942145	29	T>I		No	ClinGen gnomAD
CA377942154 COSM3806365 rs760664254	30	N>K	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA212323639 rs868851524	31	G>S		No	ClinGen Ensembl
rs1173046166 CA377942159	31	G>V		No	ClinGen gnomAD
rs1590216954 CA377942168	32	C>W		No	ClinGen Ensembl
CA377942175 rs1373736285	34	T>A		No	ClinGen gnomAD
CA377942176 rs1373736285	34	T>P		No	ClinGen gnomAD
TCGA novel	38	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1590216967 CA377942211	39	V>G		No	ClinGen Ensembl
TCGA novel	39	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326205388 CA377942214	40	P>S		No	ClinGen gnomAD
rs369401059 CA5669908	41	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1363223825 CA377942243	44	R>P		No	ClinGen TOPMed gnomAD
rs1363223825 CA377942242	44	R>Q		No	ClinGen TOPMed gnomAD
CA377942241 rs1564789532	44	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA5669909 rs755170490	45	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs964288395 CA212323665	45	E>G		No	ClinGen gnomAD
rs755170490 CA212323657	45	E>K		No	ClinGen ExAC gnomAD
rs779145933 CA5669910	46	A>G		No	ClinGen ExAC TOPMed gnomAD
CA377942250 rs1408514035	46	A>T		No	ClinGen TOPMed
rs752948206 CA5669911	50	V>I		No	ClinGen ExAC gnomAD
CA5669912 rs527650795	51	H>N		No	ClinGen 1000Genomes ExAC gnomAD
CA5669913 rs201702937	51	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747410528 CA5669914	54	V>G		No	ClinGen ExAC gnomAD
rs1027298145 CA212323686	55	A>T		No	ClinGen Ensembl
rs771537950 CA5669915	57	R>K		No	ClinGen ExAC gnomAD
CA5669937 rs80317306	61	C>W		No	ClinGen ExAC TOPMed gnomAD
CA377942749 rs1590218336	62	G>D		No	ClinGen Ensembl
CA377942760 rs1564790223	64	V>E		No	ClinGen Ensembl
CA377942761 rs1564790223	64	V>G		No	ClinGen Ensembl
rs770222107 CA5669940	71	N>D		No	ClinGen ExAC gnomAD
rs556868245 CA212279032	73	W>L		No	ClinGen Ensembl
rs1323594024 CA377942836	75	L>V		No	ClinGen gnomAD
rs1334678689 CA377942848	76	D>E		No	ClinGen gnomAD
CA212279048 rs549165947	78	G>D		No	ClinGen TOPMed
rs1280998811 CA377942871	80	G>E		No	ClinGen gnomAD
rs200487609 CA5669942	81	S>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1232508951 CA377942880	81	S>R		No	ClinGen gnomAD
CA377942887 rs1336806206	83	R>G		No	ClinGen gnomAD
TCGA novel	84	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772572895 CA5669944	85	C>F		No	ClinGen ExAC TOPMed gnomAD
rs968300059 CA212279053	88	L>F		No	ClinGen TOPMed gnomAD
CA5669945 rs144713814	89	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376960692 CA212279073	90	Q>*		No	ClinGen ESP TOPMed gnomAD
CA377942939 rs1287204760	90	Q>H		No	ClinGen TOPMed
CA212279077 rs200044145	90	Q>L		No	ClinGen 1000Genomes
rs776502872 CA5669947	93	G>S		No	ClinGen ExAC gnomAD
CA377942969 rs1387459327	95	K>R		No	ClinGen gnomAD
rs759484385 CA5669948	98	V>M		No	ClinGen ExAC gnomAD
rs764946632 CA5669949	99	T>A		No	ClinGen ExAC gnomAD
TCGA novel	102	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377943018 rs763075282	103	M>L		No	ClinGen ExAC gnomAD
CA5669951 rs763075282	103	M>V		No	ClinGen ExAC gnomAD
CA5669952 rs764428592	104	T>I		No	ClinGen ExAC gnomAD
CA212279134 rs768336799	106	G>D		No	ClinGen gnomAD
CA5669954 rs757323706	106	G>S		No	ClinGen ExAC gnomAD
rs1322002646 CA377943045	107	Q>*		No	ClinGen gnomAD
CA5669967 rs769787447	110	V>A		No	ClinGen ExAC gnomAD
CA5669968 rs775114350	112	E>Q		No	ClinGen ExAC gnomAD
CA5669969 rs762851680	114	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA377943124 rs1324570867	116	D>G		No	ClinGen gnomAD
rs1294730152 CA377943121	116	D>Y		No	ClinGen gnomAD
CA5669971 rs774570325	117	Y>C		No	ClinGen ExAC gnomAD
CA5669970 rs200488263	117	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1026219260 CA212279343	118	H>L		No	ClinGen TOPMed gnomAD
CA5669972 rs762143284	118	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1377355848 CA377943178	119	M>T		No	ClinGen TOPMed
CA5669973 rs767695284	119	M>V		No	ClinGen ExAC gnomAD
CA5669976 rs750599990	121	K>R		No	ClinGen ExAC
CA377943234 rs1260122867	122	Y>C		No	ClinGen TOPMed gnomAD
rs767043343 CA5669978	125	Q>E		No	ClinGen ExAC gnomAD
rs754325734 CA5669979	125	Q>P		No	ClinGen ExAC gnomAD
TCGA novel	127	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377943328 rs1360575705	128	N>D		No	ClinGen gnomAD
CA5669983 rs756960577	134	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1258963773 CA377943433	134	G>R		No	ClinGen TOPMed gnomAD
rs112056792 CA212279381	136	I>T		No	ClinGen gnomAD
CA212279382 rs79523510	137	E>*		No	ClinGen Ensembl
rs1363948089 CA377943491	137	E>G		No	ClinGen TOPMed
rs762165707 CA212279386	139	L>S		No	ClinGen TOPMed
CA377943522 rs1232246567	139	L>V		No	ClinGen gnomAD
rs570261906 CA5669984	142	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745420214 CA5669985	143	G>*		No	ClinGen ExAC gnomAD
CA5669986 rs769693854	144	I>T		No	ClinGen ExAC gnomAD
CA377943607 rs1487092868	147	E>K		No	ClinGen gnomAD
CA377943620 rs1590218704	148	S>N		No	ClinGen Ensembl
CA5669987 rs779988945	149	H>R		No	ClinGen ExAC gnomAD
CA377943681 rs1433349197	151	I>T		No	ClinGen TOPMed gnomAD
rs1426686843 CA377943672	151	I>V		No	ClinGen gnomAD
CA5669989 rs768444358	152	V>F		No	ClinGen ExAC TOPMed gnomAD
CA5669990 rs768444358	152	V>I		No	ClinGen ExAC TOPMed gnomAD
CA377943976 rs1590219383	154	S>*		No	ClinGen Ensembl
rs765621406 CA5670005	155	N>H		No	ClinGen ExAC gnomAD
CA377943981 rs1216109829	155	N>T		No	ClinGen gnomAD
rs753068101 CA5670006	156	C>R		No	ClinGen ExAC gnomAD
CA377943988 rs1488561502	156	C>Y		No	ClinGen gnomAD
CA377944006 rs1176256031	159	N>D		No	ClinGen gnomAD
rs1248043014 CA377944027	160	L>F		No	ClinGen gnomAD
rs1564790849 CA377944045	161	V>E		No	ClinGen Ensembl
rs1404281913 CA377944053	162	P>A		No	ClinGen TOPMed gnomAD
rs1416924116 CA377944076	163	D>E		No	ClinGen gnomAD
rs1590219407 CA377944094	165	Q>*		No	ClinGen Ensembl
rs1166838492 CA377944112	166	Q>*		No	ClinGen gnomAD
rs563943815 CA5670008	166	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780869263 CA5670009	167	V>M		No	ClinGen ExAC gnomAD
rs750094511 CA5670010	170	E>K		No	ClinGen ExAC gnomAD
rs538040244 CA212280174 COSM1345517	173	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs35232887 CA5670011 VAR_027392	173	R>W	frequency in African-Americans 0.008; not detected in Caucasian-Americans; enzyme activity is 31% of wild-type [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1230525541 CA377944357	176	K>T		No	ClinGen gnomAD
CA5670033 rs748128749	177	H>R		No	ClinGen ExAC TOPMed gnomAD
rs758201841 CA5670034	180	E>K		No	ClinGen ExAC gnomAD
rs1344988369 CA377945018	182	Y>*		No	ClinGen gnomAD
rs1484271472 CA595223244	182	Y>*		No	ClinGen TOPMed gnomAD
rs747221003 CA5670036	182	Y>H		No	ClinGen ExAC gnomAD
rs576986384 CA5670038	186	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5670039 rs745981957	188	T>M		No	ClinGen ExAC TOPMed gnomAD
CA212281192 rs946259068	189	S>T		No	ClinGen TOPMed gnomAD
CA5670041 rs775931783	191	E>V		No	ClinGen ExAC gnomAD
CA377945088 rs1448629465	193	P>S		No	ClinGen TOPMed
CA5670042 rs763450550	197	R>S		No	ClinGen ExAC gnomAD
rs556211745 CA5670043	198	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5670045 rs774767962	200	K>E		No	ClinGen ExAC gnomAD
rs1245083068 CA377945137	200	K>R		No	ClinGen TOPMed gnomAD
rs868176114 CA212281206	202	L>S		No	ClinGen Ensembl
CA5670046 rs370022454 CA5670047	203	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA377945158 rs1479096777	203	W>S		No	ClinGen gnomAD
rs776081980 CA5670068	204	G>D		No	ClinGen ExAC TOPMed gnomAD
rs759240339 CA5670069	206	C>G		No	ClinGen ExAC TOPMed gnomAD
CA212281811 rs1005762709	206	C>Y		No	ClinGen TOPMed
CA5670070 rs764828334	208	G>D		No	ClinGen ExAC gnomAD
rs1564791785 CA377945194	208	G>S		No	ClinGen Ensembl
rs1185308496 CA377945202	209	G>D		No	ClinGen TOPMed
CA377945199 rs1258791235	209	G>S		No	ClinGen TOPMed
rs556211181 CA212281829	210	A>V		No	ClinGen Ensembl
rs752321300 CA5670071	213	W>*		No	ClinGen ExAC gnomAD
CA377945234 rs1263674298	214	K>E		No	ClinGen gnomAD
CA5670072 rs758378765	215	E>*		No	ClinGen ExAC gnomAD
CA377945251 rs1210464364	216	L>R		No	ClinGen gnomAD
rs777864791 CA212281844	216	L>V		No	ClinGen Ensembl
CA5670073 rs192784484	217	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1207564649 CA377945258	218	V>I		No	ClinGen gnomAD
CA5670074 rs531874964	221	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1242157572 CA377945314	223	I>L		No	ClinGen TOPMed
rs1564791806 CA377945324	223	I>M		No	ClinGen Ensembl
CA377945334 rs1218222079	224	G>E		No	ClinGen TOPMed
CA5670075 rs370039020	226	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA377945387 rs1290660299	227	P>A		No	ClinGen TOPMed
CA5670077 rs750549428	228	P>S		No	ClinGen ExAC gnomAD
rs756399134 COSM3396889 CA5670078	229	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs896840873 CA212281856	229	R>H		No	ClinGen TOPMed gnomAD
rs756399134 CA377945415	229	R>S		No	ClinGen ExAC TOPMed gnomAD
CA5670079 rs183878464	233	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5670081 rs188603798	234	N>D		No	ClinGen 1000Genomes ExAC gnomAD
CA377945500 rs1310348676	234	N>K		No	ClinGen gnomAD
CA5670082 rs779354277	235	L>P		No	ClinGen ExAC gnomAD
CA377945527 rs1340208767	236	I>T		No	ClinGen gnomAD
rs748695393 CA5670083	236	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1363938932 CA377945659	244	E>K		No	ClinGen TOPMed
CA212281862 rs769964483	246	V>D		No	ClinGen Ensembl
rs952889240 CA212281867	247	I>V		No	ClinGen Ensembl
rs201628647 CA5670087	248	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779064702 CA5670102	250	C>G		No	ClinGen ExAC gnomAD
CA5670103 rs748589961	251	R>C		No	ClinGen ExAC gnomAD
rs139656545 CA5670104	251	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1590221596 CA377945839	255	A>S		No	ClinGen Ensembl
rs1458578761 CA377945847	256	T>I		No	ClinGen TOPMed gnomAD
CA377945850 rs1158289545	257	F>L		No	ClinGen gnomAD
rs1386310668 CA377945859	258	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1460805924 CA377945862	258	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs559312927 CA212282067 CA5670105	261	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA377945887 rs1321238990	262	H>R		No	ClinGen gnomAD
CA5670106 rs747427312	263	S>A		No	ClinGen ExAC gnomAD
rs771442515 CA5670107	263	S>C		No	ClinGen ExAC gnomAD
CA377945896 rs1303752102	264	K>E		No	ClinGen gnomAD
CA5670109 rs762696583	266	G>R		No	ClinGen ExAC gnomAD
rs1266663351 CA377945916	267	P>S		No	ClinGen gnomAD
rs768221077 CA5670112	268	T>N		No	ClinGen ExAC gnomAD
CA5670113 rs773965312	269	K>T		No	ClinGen ExAC
TCGA novel	270	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268203047 CA377945950	272	Q>P		No	ClinGen TOPMed gnomAD
rs1238646346 CA377945959	273	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5670115 rs761629464	274	I>L		No	ClinGen ExAC gnomAD
rs750353278 CA5670117	278	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1433440438 CA377945999	279	I>N		No	ClinGen TOPMed gnomAD
CA377945997 rs1311891557	279	I>V		No	ClinGen TOPMed
CA5670118 CA377946009 rs760424988	281	G>R		No	ClinGen ExAC gnomAD
rs1409508111 CA377946017	282	H>R		No	ClinGen gnomAD
CA212282162 rs1006659023	287	M>I		No	ClinGen TOPMed gnomAD
CA377946054 rs11191439	287	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5670120 VAR_027393 rs11191439	287	M>T	frequency in African-Americans 0.108 and Caucasian-Americans 0.100; enzyme activity is 350% of wild-type [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA377946066 rs1456502789	289	D>Y		No	ClinGen gnomAD
rs755252196 CA5670121	290	A>D		No	ClinGen ExAC gnomAD
CA5670122 rs372316717	291	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs967902054 CA212282185	294	F>I		No	ClinGen TOPMed
CA5670123 rs752861775	295	K>E		No	ClinGen ExAC
rs376489676 CA5670139	297	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5670140 rs200456819	297	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs759723918 CA5670141	300	V>I		No	ClinGen ExAC TOPMed gnomAD
rs765543616 CA5670143	302	V>A		No	ClinGen ExAC gnomAD
CA377947603 rs1359617892	303	D>G		No	ClinGen gnomAD
rs973756888 CA212287367	305	E>*		No	ClinGen TOPMed gnomAD
TCGA novel	305	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_027394 rs34556438 CA5670144	306	T>I	frequency in Caucasian-Americans 0.008; not detected in African-Americans [UniProt]	No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA377947677 rs1483898196	307	A>V		No	ClinGen TOPMed gnomAD
CA377947682 rs1204911434	308	A>T		No	ClinGen gnomAD
rs758462910 CA5670145	308	A>V		No	ClinGen ExAC gnomAD
CA377947697 rs1329107684	309	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5670148 rs757895180 COSM914271	311	K>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1590228456 CA377947825	317	Q>*		No	ClinGen Ensembl
CA5670151 rs202060999	317	Q>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	318	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377947859 rs1412776096	319	F>I		No	ClinGen gnomAD
CA212287410 rs982624494	319	F>L		No	ClinGen gnomAD
CA5670152 rs778590347	320	L>P		No	ClinGen ExAC gnomAD
CA377947891 rs1424241173	321	I>N		No	ClinGen gnomAD
rs1450814342 CA377947903	322	R>G		No	ClinGen gnomAD
rs928210555 CA212287416	324	I>T		No	ClinGen TOPMed gnomAD
CA5670153 rs373467176	325	G>E		No	ClinGen ESP ExAC gnomAD
rs185077443 CA5670154	326	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA377947961 rs1343799858	327	K>T		No	ClinGen gnomAD
CA5670155 rs772768594	328	L>S		No	ClinGen ExAC gnomAD
CA377947979 rs1310276047	330	T>A		No	ClinGen gnomAD
CA377948009 rs1343663349	334	C>R		No	ClinGen gnomAD
rs1564795184 CA377948022	335	S>F		No	ClinGen Ensembl
rs777191336 CA212287421	336	A>T		No	ClinGen gnomAD
rs780298293 CA5670173	341	D>V		No	ClinGen ExAC TOPMed gnomAD
rs752381804 CA5670174	343	I>N		No	ClinGen ExAC TOPMed gnomAD
CA212292851 rs752381804	343	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5670176 rs777235719	345	D>G		No	ClinGen ExAC TOPMed gnomAD
rs924879665 CA212292876	346	P>L		No	ClinGen Ensembl
CA5670177 rs369767870	349	L>F		No	ClinGen ESP ExAC gnomAD
CA377949585 rs1564797685	351	E>D		No	ClinGen Ensembl
CA377949591 rs1227102565	352	E>Q		No	ClinGen TOPMed
CA5670179 rs781065600	355	S>N		No	ClinGen ExAC gnomAD
rs201071842 CA5670178	355	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA377949683 rs1347705188	357	K>E		No	ClinGen gnomAD
CA377949691 rs1385632603	357	K>R		No	ClinGen TOPMed
rs1438187710 CA377949716	358	S>F		No	ClinGen gnomAD
rs1438187710 CA377949711	358	S>Y		No	ClinGen gnomAD
CA377949741 rs1326666544	360	C>Y		No	ClinGen gnomAD
CA212292911 rs943149808	362	P>L		No	ClinGen TOPMed
rs1283609623 CA377949781	363	D>N		No	ClinGen gnomAD
CA5670182 rs182365639	363	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769572838 CA5670183	365	A>P		No	ClinGen ExAC TOPMed gnomAD
CA377949825 rs1564797715	365	A>V		No	ClinGen Ensembl
rs1462257328 CA377949846	367	G>S		No	ClinGen TOPMed
CA377949876 rs1590234330	368	C>W		No	ClinGen Ensembl
CA5670185 rs763227721	369	C>R		No	ClinGen ExAC gnomAD
CA377949920 rs1374630100	371	T>A		No	ClinGen TOPMed
rs1287846295 CA377950003	375	C>*		No	ClinGen TOPMed gnomAD

No associated diseases with Q9HBK9

1 regional properties for Q9HBK9

Type	Name	Position	InterPro Accession
domain	Methyltransferase domain	70 - 215	IPR025714

Functions

		Description
EC Number	2.1.1.137	Methyltransferases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name	Definition
arsenite methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
methylarsonite methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
methyltransferase activity	Catalysis of the transfer of a methyl group to an acceptor molecule.

3 GO annotations of biological process

Name	Definition
arsonoacetate metabolic process	The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides.
methylation	The process in which a methyl group is covalently attached to a molecule.
toxin metabolic process	The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q91WU5	As3mt	Arsenite methyltransferase	Mus musculus (Mouse)	PR
Q8VHT6	As3mt	Arsenite methyltransferase	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAALRDAEIQ	KDVQTYYGQV	LKRSADLQTN	GCVTTARPVP	KHIREALQNV	HEEVALRYYG
70	80	90	100	110	120
CGLVIPEHLE	NCWILDLGSG	SGRDCYVLSQ	LVGEKGHVTG	IDMTKGQVEV	AEKYLDYHME
130	140	150	160	170	180
KYGFQASNVT	FIHGYIEKLG	EAGIKNESHD	IVVSNCVINL	VPDKQQVLQE	AYRVLKHGGE
190	200	210	220	230	240
LYFSDVYTSL	ELPEEIRTHK	VLWGECLGGA	LYWKELAVLA	QKIGFCPPRL	VTANLITIQN
250	260	270	280	290	300
KELERVIGDC	RFVSATFRLF	KHSKTGPTKR	CQVIYNGGIT	GHEKELMFDA	NFTFKEGEIV
310	320	330	340	350	360
EVDEETAAIL	KNSRFAQDFL	IRPIGEKLPT	SGGCSALELK	DIITDPFKLA	EESDSMKSRC
370
VPDAAGGCCG	TKKSC