Q8VHT6

PR
Gene name
As3mt (Cyt19)
Protein name
Arsenite methyltransferase
Names
Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:140925
EC number
2.1.1.137: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

315-369 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VHT6

Entry ID Method Resolution Chain Position Source
AF-Q8VHT6-F1 Predicted AlphaFoldDB

No variants for Q8VHT6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8VHT6

No associated diseases with Q8VHT6

1 regional properties for Q8VHT6

Type Name Position InterPro Accession
domain Methyltransferase domain 70 - 211 IPR025714

Functions

Description
EC Number 2.1.1.137 Methyltransferases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
arsenite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
methylarsonite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein.
S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

4 GO annotations of biological process

Name Definition
arsonoacetate metabolic process The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides.
methylation The process in which a methyl group is covalently attached to a molecule.
response to arsenic-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HBK9 AS3MT Arsenite methyltransferase Homo sapiens (Human) PR
Q91WU5 As3mt Arsenite methyltransferase Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAPRDAEIH KDVQNYYGNV LKTSADLQTN ACVTPAKGVP EYIRKSLQNV HEEVISRYYG
70 80 90 100 110 120
CGLVVPEHLE NCRILDLGSG SGRDCYVLSQ LVGQKGHITG IDMTKVQVEV AKAYLEYHTE
130 140 150 160 170 180
KFGFQTPNVT FLHGQIEMLA EAGIQKESYD IVISNCVINL VPDKQKVLRE VYQVLKYGGE
190 200 210 220 230 240
LYFSDVYASL EVSEDIKSHK VLWGECLGGA LYWKDLAVIA KKIGFCPPRL VTANIITVGN
250 260 270 280 290 300
KELERVLGDC RFVSATFRLF KLPKTEPAGR CQVVYNGGIM GHEKELIFDA NFTFKEGEAV
310 320 330 340 350 360
EVDEETAAIL RNSRFAHDFL FTPVEASLLA PQTKVIIRDP FKLAEESDKM KPRCAPEGTG
GCCGKRKSC