AiPD: Autoinhibited Protein Database

Gene name	As3mt (Cyt19)
Protein name	Arsenite methyltransferase
Names	Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:57344
EC number	2.1.1.137: Methyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

5-77 (Predicted disordered autoinhibitory region) PR

5-77 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q91WU5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389560471	8	D>N	No	EVA
rs3389523753	9	E>K	No	EVA
rs13463721	33	C>Y	No	EVA
rs3389511493	81	G>E	No	EVA
rs3389523812	85	D>V	No	EVA
rs13463720	106	E>K	No	EVA
rs3389537872	138	E>*	No	EVA
rs3389555906	185	S>N	No	EVA
rs3389555913	195	E>D	No	EVA
rs3389544765	213	Y>N	No	EVA
rs254223141	219	I>M	No	EVA
rs237996267	237	I>V	No	EVA
rs232506357	247	V>F	No	EVA
rs3389523794	258	F>C	No	EVA
rs3389537836	292	N>Y	No	EVA
rs50841425	299	E>K	No	EVA
rs3389511438	319	D>E	No	EVA
rs251162425	328	S>L	No	EVA
rs3389544793	334	G>S	No	EVA
rs46787138	335	R>H	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q91WU5

		Description
EC Number	2.1.1.137	Methyltransferases
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
arsenite methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
methylarsonite methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
methyltransferase activity	Catalysis of the transfer of a methyl group to an acceptor molecule.

Name	Definition
arsonoacetate metabolic process	The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides.
methylation	The process in which a methyl group is covalently attached to a molecule.
response to arsenic-containing substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
toxin metabolic process	The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9HBK9	AS3MT	Arsenite methyltransferase	Homo sapiens (Human)	PR
Q8VHT6	As3mt	Arsenite methyltransferase	Rattus norvegicus (Rat)	PR