AiPD: Autoinhibited Protein Database

Q9H6T3

Gene name	RPAP3
Protein name	RNA polymerase II-associated protein 3
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79657
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-156 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

78-156 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

11 structures for Q9H6T3

Entry ID	Method	Resolution	Chain	Position	Source
4CGV	X-ray	254 A	A/B/C/D	120-255	PDB
4CGW	X-ray	300 A	A/B	265-381	PDB
6EZ4	NMR	-	A	535-665	PDB
6FD7	NMR	-	A	133-255	PDB
6FDP	NMR	-	A	281-395	PDB
6FDT	NMR	-	A	281-396	PDB
6FM8	X-ray	178 A	A	576-625	PDB
6FO1	EM	357 A	G	1-665	PDB
6GXZ	X-ray	296 A	A/C	281-445	PDB
6ZBK	X-ray	149 A	A	133-255	PDB
AF-Q9H6T3-F1	Predicted				AlphaFoldDB

494 variants for Q9H6T3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs886300491 CA236475510	2	T>A		No	ClinGen Ensembl
rs1451859790 CA384511024	3	S>A		No	ClinGen TOPMed
CA6530688 rs182172391	7	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384510990 rs1176345423	8	I>V		No	ClinGen TOPMed gnomAD
rs1051630838 CA236475479	9	E>D		No	ClinGen TOPMed gnomAD
COSM176797 CA6530687 rs761613202	9	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6530686 rs774310982	12	L>P		No	ClinGen ExAC gnomAD
rs781449266 CA6530684	16	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA6530683 rs776917570	17	N>H		No	ClinGen ExAC TOPMed gnomAD
CA384510927 rs1405565880	17	N>S		No	ClinGen TOPMed gnomAD
CA384510929 rs776917570	17	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs1489007048 CA384510892	22	Q>*		No	ClinGen TOPMed
CA384510888 rs747245634	22	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs190469889 CA6530680	24	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6530679 rs144653550	26	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs374367674 CA6530676	26	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374367674 CA6530677	26	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6530678 rs144653550	26	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs200443326 CA6530675	27	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200443326 CA6530674	27	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	32	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755707813 CA6530672	33	K>N		No	ClinGen ExAC gnomAD
rs1044795496 CA236475402	33	K>R		No	ClinGen gnomAD
TCGA novel	39	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6530671 rs750119778	40	M>V		No	ClinGen ExAC gnomAD
rs1485320248 CA384510696	41	E>K		No	ClinGen gnomAD
rs767111937 CA6530670	42	L>P		No	ClinGen ExAC TOPMed gnomAD
rs767111937 CA236475387	42	L>R		No	ClinGen ExAC TOPMed gnomAD
CA6530668 rs751364323	46	N>K		No	ClinGen ExAC gnomAD
COSM4150105 CA236475365 rs934812452	47	G>D	ovary [Cosmic]	No	ClinGen cosmic curated Ensembl
rs989050970 CA236475366	47	G>S		No	ClinGen Ensembl
CA6530667 rs544943912	48	V>G		No	ClinGen 1000Genomes ExAC gnomAD
CA384510609 rs1457168144	49	P>T		No	ClinGen TOPMed
rs776792610 CA6530665	50	E>G		No	ClinGen ExAC gnomAD
rs370359722 CA6530666	50	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6530643 rs773222451	56	I>V		No	ClinGen ExAC gnomAD
rs761948776 CA6530641	58	N>S		No	ClinGen ExAC
rs997144280 CA236474472 COSM3416881	60	N>S	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs769034382 CA6530639	63	K>E		No	ClinGen ExAC gnomAD
CA384510063 rs1242180754	66	K>T		No	ClinGen TOPMed gnomAD
CA6530637 rs775951773	67	G>D		No	ClinGen ExAC TOPMed gnomAD
CA236474453 rs1038540943	67	G>S		No	ClinGen TOPMed gnomAD
CA384510045 rs1295032389	68	K>E		No	ClinGen TOPMed
CA236474435 rs908977487	70	K>N		No	ClinGen gnomAD
rs745374505 CA6530635	70	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1448403638 CA384509990	71	E>D		No	ClinGen gnomAD
rs200333932 CA6530634	71	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA384509994 rs1316014670	71	E>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384509969 rs1592488977	73	S>Y		No	ClinGen Ensembl
rs1326677198	76	T>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	76	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	78	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1455423472 CA384509886	79	E>D		No	ClinGen TOPMed gnomAD
CA384509866 rs1413957222	81	T>A		No	ClinGen gnomAD
TCGA novel	82	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384509833 rs1182668677	84	R>G		No	ClinGen gnomAD
CA236474383 rs550674751	84	R>S		No	ClinGen 1000Genomes
rs756875418 CA6530631	85	I>T		No	ClinGen ExAC gnomAD
rs928939148 CA236474379	85	I>V		No	ClinGen gnomAD
rs746662437 CA6530630	86	K>T		No	ClinGen ExAC gnomAD
rs1362399482 CA384509732	93	W>R		No	ClinGen gnomAD
CA236474366 rs530474989	94	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs530474989 CA6530628	94	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs369727824 CA236474343	98	V>E		No	ClinGen ESP TOPMed gnomAD
rs138031379 CA6530607	100	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777547327 CA6530606	100	R>H		No	ClinGen ExAC TOPMed gnomAD
rs369699014 CA236466621	103	D>N		No	ClinGen gnomAD
TCGA novel	103	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747952814 CA384509092	104	E>K		No	ClinGen ExAC gnomAD
rs747952814 CA6530604	104	E>Q		No	ClinGen ExAC gnomAD
CA384509051 rs1317197532	107	K>T		No	ClinGen gnomAD
rs150350108 CA6530602	108	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA236466604 rs994992515	109	D>G		No	ClinGen TOPMed gnomAD
rs1391274800 CA384509039	109	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6530601 rs753744196	110	S>I		No	ClinGen ExAC gnomAD
rs1468222855 CA384509025	111	T>A		No	ClinGen TOPMed
rs1430653316 CA384509022	111	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	113	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757260445 CA6530599	114	S>C		No	ClinGen ExAC gnomAD
rs151225713 CA384508999	115	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs151225713 CA6530598	115	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs200075662 CA6530597	117	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	118	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM72478 CA384508958 rs1279256902	121	S>A	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs374360356 COSM1361806 CA6530596	121	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA236466563 rs761096038	122	E>*		No	ClinGen Ensembl
CA6530594 rs143202605	122	E>G		No	ClinGen ESP ExAC gnomAD
CA6530593 rs200770635	123	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs750480505 CA236466543	124	D>H		No	ClinGen TOPMed gnomAD
CA384508918 rs1307794902	127	H>R		No	ClinGen TOPMed
CA6530589 rs772923540	132	K>N		No	ClinGen ExAC TOPMed gnomAD
CA6530590 rs771519429	132	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs771787826 CA6530587	133	A>P		No	ClinGen ExAC gnomAD
rs771787826 CA384508857	133	A>S		No	ClinGen ExAC gnomAD
rs1359840156 CA384508853	133	A>V		No	ClinGen TOPMed
rs1244934875 CA384508849	134	L>F		No	ClinGen TOPMed
rs1236122914 CA384508837	135	V>A		No	ClinGen gnomAD
rs1451515631 CA384508810	138	E>*		No	ClinGen gnomAD
COSM348673 rs1451515631 CA384508812	138	E>Q	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA6530585 rs767728120	139	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1232257829 CA384508720	140	G>S		No	ClinGen gnomAD
CA6530569 rs766791863	141	N>S		No	ClinGen ExAC gnomAD
CA689402252 rs1465414297	143	Y>*		No	ClinGen TOPMed
rs1221246968 CA384508654	145	K>N		No	ClinGen gnomAD
rs1592485725 CA384508632	147	G>E		No	ClinGen Ensembl
rs1387060444 CA384508613	149	Y>C		No	ClinGen TOPMed
CA6530567 rs772794029	150	D>G		No	ClinGen ExAC gnomAD
rs1222445274 CA384508603	150	D>Y		No	ClinGen gnomAD
rs947556681 CA236465678	152	A>T		No	ClinGen Ensembl
CA6530564 rs761519915	154	D>G		No	ClinGen ExAC gnomAD
rs1337825961 CA384508559	154	D>H		No	ClinGen TOPMed
rs773848035 CA6530563	155	C>R		No	ClinGen ExAC gnomAD
CA6530561 rs142330780	157	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs539839637 CA384508489 CA6530559	160	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA236465656 rs775355665	160	M>L		No	ClinGen ExAC TOPMed gnomAD
CA6530560 rs775355665	160	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6530557 rs777790875	161	D>E		No	ClinGen ExAC gnomAD
rs1254572882 CA384508482	161	D>G		No	ClinGen TOPMed
CA6530558 rs745826626	161	D>H		No	ClinGen ExAC gnomAD
rs868582798 CA236465647	162	A>V		No	ClinGen Ensembl
CA6530555 rs748274753	163	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1487379083 CA384508440	165	Y>C		No	ClinGen TOPMed
TCGA novel	165	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6530554 rs778990593	166	N>D		No	ClinGen ExAC gnomAD
CA6530553 rs755294849	167	P>L		No	ClinGen ExAC TOPMed gnomAD
CA384508418 rs755294849	167	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1266853670 CA384508423	167	P>T		No	ClinGen gnomAD
CA6530551 COSM939673 rs371796000	168	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA6530550 rs756644826	169	L>F		No	ClinGen ExAC gnomAD
CA6530549 rs751001324	170	P>L		No	ClinGen ExAC
CA6530548 rs768182145	171	T>A		No	ClinGen ExAC TOPMed gnomAD
rs761391075 CA384508387	171	T>K		No	ClinGen ExAC gnomAD
rs761391075 CA6530547	171	T>M		No	ClinGen ExAC gnomAD
rs763583598 CA6530545	172	N>K		No	ClinGen ExAC gnomAD
rs866675210 CA236465574	173	R>K		No	ClinGen Ensembl
CA236465564 rs368272179 COSM1361805	174	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
CA6530543 rs775098141	174	A>V		No	ClinGen ExAC gnomAD
rs993326819 CA236465555	180	L>V		No	ClinGen TOPMed
CA384507261 rs1412596307	183	F>C		No	ClinGen TOPMed
TCGA novel	184	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6530530 rs768131123	191	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6530528 rs769966506	193	A>S		No	ClinGen ExAC gnomAD
CA6530529 rs769966506	193	A>T		No	ClinGen ExAC gnomAD
CA6530526 rs746148571	194	V>L		No	ClinGen ExAC gnomAD
rs772091518 CA384506996	195	A>S		No	ClinGen TOPMed
CA236461819 rs772091518	195	A>T		No	ClinGen TOPMed
CA384506966 rs1171918577	197	N>S		No	ClinGen gnomAD
CA6530525 rs775177297	198	R>T		No	ClinGen ExAC gnomAD
CA6530524 rs555701427	199	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1436768294 CA384506918	199	S>R		No	ClinGen TOPMed
rs370357624 CA6530523	201	T>A		No	ClinGen ESP ExAC gnomAD
CA6530522 rs776478652	202	K>N		No	ClinGen ExAC gnomAD
CA384506872 rs1592481918	202	K>R		No	ClinGen Ensembl
rs1186463939 CA384506858	203	A>P		No	ClinGen gnomAD
CA6530521 rs202047980	205	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1345340407 CA384506812	206	R>T		No	ClinGen TOPMed
CA6530520 rs367995387	207	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA6530518 COSM693850 rs768816369	207	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	210	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749369834 CA6530517	210	A>V		No	ClinGen ExAC gnomAD
CA384506746 rs1282260549	211	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs139987705 CA236461792	212	F>L		No	ClinGen ESP gnomAD
CA6530516 rs780403948	213	A>G		No	ClinGen ExAC gnomAD
rs1484555410 CA384506721	213	A>T		No	ClinGen gnomAD
CA6530514 rs746165934	218	E>D		No	ClinGen ExAC gnomAD
CA384506653 rs1343066604	218	E>K		No	ClinGen gnomAD
rs1565720595 CA384506620	219	E>D		No	ClinGen Ensembl
CA384506636 rs1244136756	219	E>K		No	ClinGen gnomAD
rs145789473 CA6530513	220	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs145789473 CA6530512	220	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1268435987 CA384506590	221	K>N		No	ClinGen TOPMed
CA6530511 rs752138258	223	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1169229941 CA384505817	224	Y>D		No	ClinGen TOPMed
CA384505805 rs1432048718	224	Y>F		No	ClinGen TOPMed
CA236460635 rs199890720	225	E>G		No	ClinGen TOPMed gnomAD
CA236460632 rs377575216	227	V>A		No	ClinGen gnomAD
rs1384140874 CA384505684	233	N>S		No	ClinGen TOPMed
CA6530485 rs778328621	234	N>K		No	ClinGen ExAC gnomAD
rs138580530 CA6530484	235	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1289625368 CA384505606	239	N>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1592480841 CA384505503	245	S>N		No	ClinGen Ensembl
rs952988463 CA236460607	245	S>R		No	ClinGen TOPMed
rs771116418 CA6530466	247	A>G		No	ClinGen ExAC gnomAD
rs1209335748 CA384505311	247	A>T		No	ClinGen TOPMed gnomAD
rs149831248 CA6530464	248	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA384505261 rs972933355	250	S>F		No	ClinGen TOPMed
CA6530463 rs772573715	250	S>P		No	ClinGen ExAC gnomAD
CA236459707 rs972933355	250	S>Y		No	ClinGen TOPMed
CA6530462 rs370722633	251	K>R		No	ClinGen ESP ExAC gnomAD
CA384505232 rs1436299134	252	E>V		No	ClinGen gnomAD
rs1354433044 CA384505197	255	Y>H		No	ClinGen TOPMed gnomAD
rs1332769853 CA384505183	255	Y>S		No	ClinGen gnomAD
rs1414464088 CA384505165	256	P>L		No	ClinGen gnomAD
CA384505161 rs754455964	257	K>E		No	ClinGen ExAC TOPMed gnomAD
CA6530460 rs754455964	257	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA384505057 rs1465178509	262	V>A		No	ClinGen TOPMed gnomAD
CA6530458 rs779747752	262	V>L		No	ClinGen ExAC
rs1249721189 CA384505047	263	I>F		No	ClinGen gnomAD
rs755792667 CA6530456	263	I>T		No	ClinGen ExAC gnomAD
CA236459638 rs753267036	264	K>N		No	ClinGen TOPMed gnomAD
rs1286245368 CA384504983	266	T>K		No	ClinGen gnomAD
rs750171115 CA6530455	267	E>K		No	ClinGen ExAC gnomAD
rs1339566430 CA384504954	268	G>R		No	ClinGen gnomAD
COSM1240094 CA6530453 rs757218659	270	R>*	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA384504922 rs757218659	270	R>G		No	ClinGen ExAC TOPMed gnomAD
CA6530452 rs764174535	270	R>L		No	ClinGen ExAC TOPMed gnomAD
rs764174535 CA6530451	270	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6530450 rs759673181	273	I>T		No	ClinGen ExAC gnomAD
rs901450550 CA236459616	274	E>D		No	ClinGen Ensembl
rs766555295 CA6530448	277	Q>H		No	ClinGen ExAC gnomAD
CA384504321 rs1351055782	278	N>K		No	ClinGen TOPMed gnomAD
rs1336198208 CA384504325	278	N>S		No	ClinGen TOPMed gnomAD
rs1375944568 CA384504314	279	K>T		No	ClinGen TOPMed
rs1322240236 CA384504278	282	A>D		No	ClinGen TOPMed gnomAD
CA6530446 rs377619102	283	I>V		No	ClinGen ESP ExAC gnomAD
rs772355326 CA6530445	285	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA6530444 rs774819368	288	R>G		No	ClinGen ExAC gnomAD
rs139952845 CA6530442	288	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6530443 rs774819368	288	R>W		No	ClinGen ExAC gnomAD
CA236459046 rs1033277242	291	G>*		No	ClinGen TOPMed gnomAD
rs769153971 CA6530414	297	K>N		No	ClinGen ExAC gnomAD
rs567025650 CA236459029 CA384504057	298	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA689431599 rs1278355304	300	R>*		No	ClinGen TOPMed
CA6530412 rs763440593	300	R>T		No	ClinGen ExAC gnomAD
CA6530410 rs746734456	302	I>T		No	ClinGen ExAC gnomAD
rs150689330 CA6530411	302	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA384503972 rs1365671466	306	T>S		No	ClinGen gnomAD
CA384503965 rs1293156562	307	R>*		No	ClinGen TOPMed gnomAD
rs189398208 CA236458996	307	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6530409 rs189398208	307	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6530408 rs377484905	308	G>E		No	ClinGen ESP ExAC gnomAD
CA6530407 rs144540934	310	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs756126888 CA6530406	311	A>E		No	ClinGen ExAC gnomAD
CA6530405 rs756126888	311	A>V		No	ClinGen ExAC gnomAD
CA236458969 rs925882161	312	D>G		No	ClinGen TOPMed gnomAD
rs1474550469 CA384503906	314	A>T		No	ClinGen TOPMed
CA6530404 rs750576949	314	A>V		No	ClinGen ExAC gnomAD
CA384503898 rs1159188794	315	N>D		No	ClinGen gnomAD
rs1420360337 CA384503894	315	N>I		No	ClinGen gnomAD
CA6530403 rs767725622	316	A>T		No	ClinGen ExAC gnomAD
CA236458959 rs978589637	316	A>V		No	ClinGen gnomAD
CA6530401 rs751868721	318	L>F		No	ClinGen ExAC gnomAD
rs764470160 CA6530400	321	N>D		No	ClinGen ExAC gnomAD
CA384503820 rs1329010230	322	R>G		No	ClinGen gnomAD
rs1196452011 CA384503797	323	A>G		No	ClinGen TOPMed
rs1424483521 CA384503756	325	A>V		No	ClinGen TOPMed
rs763412726 CA6530399	326	Y>C		No	ClinGen ExAC gnomAD
rs1310504721 CA384503685	330	Q>*		No	ClinGen gnomAD
CA384503681 rs1300738514	330	Q>R		No	ClinGen gnomAD
CA384503094 rs751745819	331	K>N		No	ClinGen ExAC TOPMed gnomAD
rs977777702 CA236455333	332	Y>C		No	ClinGen TOPMed
TCGA novel	333	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA236455323 rs1030168716	334	E>G		No	ClinGen Ensembl
rs1350257107 CA384503056	334	E>K		No	ClinGen gnomAD
rs1408818036 CA384503027	336	E>*		No	ClinGen TOPMed
CA384503024 rs1360471691	336	E>D		No	ClinGen TOPMed
CA6530381 rs758674512	336	E>V		No	ClinGen ExAC TOPMed
CA6530380 rs753170805	340	T>A		No	ClinGen ExAC gnomAD
CA6530379 rs540039944	340	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6530378 rs760102251	341	Q>E		No	ClinGen ExAC gnomAD
rs760102251 CA384502964	341	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	342	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766019965 CA6530376	343	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384502830 rs1400006886	346	D>G		No	ClinGen gnomAD
rs1451073376 CA384502824	347	G>C		No	ClinGen TOPMed
rs760302949 CA6530375	348	S>P		No	ClinGen ExAC gnomAD
rs772978474 CA6530374	349	Y>H		No	ClinGen ExAC gnomAD
rs1300387176 CA384502761	356	R>S		No	ClinGen TOPMed
rs1194364675 CA384502750	358	T>S		No	ClinGen gnomAD
CA384502747 rs1448554021	359	A>S		No	ClinGen gnomAD
CA384502748 rs1448554021	359	A>T		No	ClinGen gnomAD
CA384502742 rs1362790734	360	R>G		No	ClinGen TOPMed
rs185854362 CA6530373	361	T>R		No	ClinGen 1000Genomes ExAC gnomAD
CA6530371 rs774203420	363	L>S		No	ClinGen ExAC TOPMed gnomAD
CA6530369 rs749250833	364	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6530370 rs749250833	364	G>E		No	ClinGen ExAC TOPMed gnomAD
CA384502713 rs749250833	364	G>V		No	ClinGen ExAC TOPMed gnomAD
rs975991707 CA236455255	367	N>S		No	ClinGen TOPMed
CA6530367 rs555920494	371	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA384502565 rs1421669762	373	F>L		No	ClinGen TOPMed
CA6530350 rs775389930	376	V>D		No	ClinGen ExAC gnomAD
TCGA novel	377	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs994610481 CA236453885	378	L>R		No	ClinGen Ensembl
rs888662976 CA236453848	383	N>S		No	ClinGen TOPMed
rs1027249990 CA236453844	385	Q>R		No	ClinGen TOPMed
rs777920088 CA6530347	386	A>G		No	ClinGen ExAC gnomAD
TCGA novel	387	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA236453839 rs142406061	389	E>G		No	ClinGen ESP TOPMed
CA384502382 rs1592474860	391	S>C		No	ClinGen Ensembl
rs1164228482 CA384502375	392	K>E		No	ClinGen gnomAD
rs748433627 CA6530346	392	K>R		No	ClinGen ExAC TOPMed gnomAD
rs748433627 CA6530345	392	K>T		No	ClinGen ExAC TOPMed gnomAD
CA6530344 rs779043728	394	K>R		No	ClinGen ExAC gnomAD
rs755348161 CA6530343	395	K>N		No	ClinGen ExAC gnomAD
rs1388535551 CA384502255	399	E>D		No	ClinGen gnomAD
CA6530325 rs748226237	399	E>Q		No	ClinGen ExAC gnomAD
rs1478389828 CA384502234	401	G>E		No	ClinGen TOPMed
TCGA novel	401	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA236453669 rs148012785	405	D>E		No	ClinGen ESP TOPMed gnomAD
rs1469650739 CA384502191	405	D>Y		No	ClinGen gnomAD
CA6530324 rs779184026	410	S>C		No	ClinGen ExAC TOPMed gnomAD
CA236453661 rs764483511	411	T>A		No	ClinGen Ensembl
CA384502098 rs1447542607	413	R>S		No	ClinGen gnomAD
rs1052879674 CA236453660	414	Q>P		No	ClinGen TOPMed
rs769068751 CA6530323	416	V>M		No	ClinGen ExAC gnomAD
CA384502067 rs1198240799	417	V>L		No	ClinGen gnomAD
CA384502046 rs1565716876	419	P>S		No	ClinGen Ensembl
CA384502039 rs375056834	420	I>L		No	ClinGen ESP gnomAD
rs375056834 CA236453651	420	I>V		No	ClinGen ESP gnomAD
rs1055715545 CA236453649	423	P>L		No	ClinGen TOPMed gnomAD
CA6530321 rs749599471 COSM267353	424	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs749599471 CA236453647	424	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1347111306 CA384501989	425	H>Y		No	ClinGen TOPMed
CA384501974 rs934495973	426	P>S		No	ClinGen TOPMed gnomAD
rs934495973 CA236453612	426	P>T		No	ClinGen TOPMed gnomAD
CA6530319 rs756643050	427	G>*		No	ClinGen ExAC gnomAD
CA6530318 rs144528022	427	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384501967 rs756643050	427	G>R		No	ClinGen ExAC gnomAD
rs1376214944 CA384501956	428	S>L		No	ClinGen TOPMed gnomAD
rs1309988486 CA384501953	429	T>A		No	ClinGen TOPMed
rs1161366989 CA384501703	432	L>R		No	ClinGen gnomAD
CA384501707 rs1304190739 COSM131130	432	L>V	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
rs551301038 CA6530304	434	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1257555646 CA384501691	434	K>R		No	ClinGen gnomAD
rs1026345061 CA236446465	435	V>L		No	ClinGen TOPMed
CA6530303 rs368438367	436	I>F		No	ClinGen ESP ExAC gnomAD
rs1250624007 CA384501674	437	I>L		No	ClinGen gnomAD
CA6530302 rs376683177	440	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA236446441 rs149293092	441	G>D		No	ClinGen ESP TOPMed gnomAD
rs372384112 CA6530301	441	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1228225145 COSM1705505 CA384501630	443	L>F	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs770256863 CA6530300	445	Q>*		No	ClinGen ExAC gnomAD
CA384501611 TCGA novel rs1481234160	446	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
rs531087920 CA6530299	447	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531087920 CA6530298	447	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6530297 rs757705979	452	S>G		No	ClinGen ExAC TOPMed gnomAD
CA6530296 rs746467436	452	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA384501570 rs758005169	453	T>A		No	ClinGen ExAC gnomAD
CA6530294 rs758005169	453	T>P		No	ClinGen ExAC gnomAD
CA384501547 rs1460813801	457	A>T		No	ClinGen gnomAD
rs138605014 CA6530292	458	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565713635 CA384501484	466	A>S		No	ClinGen Ensembl
CA384501481 rs1406686922	466	A>V		No	ClinGen gnomAD
CA6530290 rs764521578	467	N>K		No	ClinGen ExAC gnomAD
CA384501473 rs1459694996	468	V>I		No	ClinGen TOPMed
rs760545058 CA6530288	469	I>T		No	ClinGen ExAC TOPMed gnomAD
CA6530289 rs766275122	469	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384501462 rs1221309385	470	A>T		No	ClinGen gnomAD
rs774443950 CA6530287	471	A>V		No	ClinGen ExAC gnomAD
rs764305087 CA6530286	472	T>I		No	ClinGen ExAC gnomAD
CA6530285 rs763469006	475	T>I		No	ClinGen ExAC gnomAD
CA384501421 rs1170594958	477	K>E		No	ClinGen TOPMed gnomAD
CA6530284 rs775837173	478	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1307845532 CA384501410	478	K>T		No	ClinGen gnomAD
rs770203975 CA6530283	481	S>N		No	ClinGen ExAC gnomAD
rs1291517913 CA384501372	483	D>V		No	ClinGen gnomAD
CA384501369 rs1439901838	484	D>N		No	ClinGen gnomAD
CA6530282 rs746174790	485	L>F		No	ClinGen ExAC gnomAD
CA384501360 rs746174790	485	L>V		No	ClinGen ExAC gnomAD
CA236446282 rs975080454	487	P>H		No	ClinGen Ensembl
CA6530280 rs771417626	488	T>K		No	ClinGen ExAC TOPMed gnomAD
rs776870361 CA6530281	488	T>P		No	ClinGen ExAC TOPMed gnomAD
CA6530279 rs747500555	489	S>C		No	ClinGen ExAC gnomAD
rs377599159 CA236446275	489	S>N		No	ClinGen TOPMed gnomAD
rs1231896476 CA384501330	490	D>G		No	ClinGen TOPMed
CA384501313 rs1159239794	493	R>G		No	ClinGen TOPMed gnomAD
rs778292657 CA6530278	496	V>A		No	ClinGen ExAC gnomAD
CA384501291 rs1473690661	496	V>L		No	ClinGen gnomAD
CA236446271 rs1042095531	497	L>F		No	ClinGen TOPMed
CA6530277 rs146145310	497	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1231616213 CA384501268	499	I>M		No	ClinGen TOPMed
TCGA novel	501	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384501244 rs1255335575	503	S>G		No	ClinGen gnomAD
rs113096543 CA6530274	504	D>G		No	ClinGen Ensembl
CA6530272 rs373147823	505	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6530271 rs373147823	505	T>P		No	ClinGen ExAC TOPMed gnomAD
CA384501215 rs1310594344	507	S>F		No	ClinGen gnomAD
CA6530269 rs766133338	509	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1167029790 CA384501187	510	P>R		No	ClinGen gnomAD
CA384501180 rs1237887819	511	Q>H		No	ClinGen TOPMed
rs75275772 CA236445610	511	Q>K		No	ClinGen Ensembl
CA384501167 rs1374053570	513	S>I		No	ClinGen gnomAD
rs1374053570 CA384501168	513	S>T		No	ClinGen gnomAD
rs1258526872 CA384501163	514	L>V		No	ClinGen TOPMed
CA6530248 rs781275030	518	V>I		No	ClinGen ExAC gnomAD
TCGA novel	520	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1188779531 CA384501108	521	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs199534990 CA6530245	523	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384501093 rs765275115	523	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1338476521 CA384501091	524	E>K		No	ClinGen gnomAD
CA384501064 rs1251710998	527	P>S		No	ClinGen gnomAD
CA384501055 rs1565713131	528	I>M		No	ClinGen Ensembl
CA6530243 rs772086384	528	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384501051 rs1349506887	529	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6530242 rs142310260	530	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA236445547 rs773883246	530	I>T		No	ClinGen TOPMed gnomAD
rs1292071295 CA384501039	531	E>*		No	ClinGen gnomAD
CA6530241 rs766637144	537	F>L		No	ClinGen ExAC TOPMed gnomAD
rs760962372 CA6530240	539	T>I		No	ClinGen ExAC gnomAD
CA6530239 rs773632539	540	T>I		No	ClinGen ExAC TOPMed gnomAD
rs563331115 CA6530238	542	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs138253744 CA6530237	543	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1456799023 CA384500957	544	P>A		No	ClinGen TOPMed gnomAD
rs1456799023 CA384500956	544	P>S		No	ClinGen TOPMed gnomAD
CA384500939 rs1476218030	547	A>T		No	ClinGen gnomAD
CA236445475 rs796820212	547	A>V		No	ClinGen Ensembl
rs779510671 CA6530233	549	S>L		No	ClinGen ExAC gnomAD
rs779510671 CA6530234	549	S>W		No	ClinGen ExAC gnomAD
CA6530231 rs745648332	550	F>L		No	ClinGen ExAC gnomAD
rs1250910308 CA384500909	551	Q>H		No	ClinGen TOPMed gnomAD
CA236445430 rs916413198	551	Q>R		No	ClinGen Ensembl
rs781185048 CA6530230	552	L>F		No	ClinGen ExAC gnomAD
rs958331895 CA236445394	553	E>D		No	ClinGen Ensembl
CA6530227 COSM3812084 rs777789963	553	E>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6530226 rs754954744	555	D>H		No	ClinGen ExAC gnomAD
rs1032441799 CA236445368	557	R>T		No	ClinGen Ensembl
rs1481012056 CA384500866	558	Q>R		No	ClinGen TOPMed
CA6530224 rs766505474	560	K>R		No	ClinGen ExAC TOPMed gnomAD
rs112192272 CA6530223	561	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA384500845 rs112192272	561	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	562	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_057354 rs11168196 CA6530222	564	D>Y		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA236445347 rs183182384	565	M>T		No	ClinGen 1000Genomes gnomAD
CA384500813 rs1592467833	566	L>V		No	ClinGen Ensembl
CA6530221 rs767906024	567	Y>C		No	ClinGen ExAC gnomAD
rs762193325 CA6530220	568	Q>E		No	ClinGen ExAC gnomAD
rs764500345 CA384500757	572	Q>*		No	ClinGen ExAC gnomAD
CA6530196 rs764500345	572	Q>K		No	ClinGen ExAC gnomAD
rs761807080 CA236444575	575	P>L		No	ClinGen Ensembl
CA6530195 rs763567998	575	P>S		No	ClinGen ExAC gnomAD
CA6530193 rs764801994	576	S>Y		No	ClinGen ExAC gnomAD
rs1236960435 CA384500685	582	F>L		No	ClinGen gnomAD
rs200439810 CA6530191	582	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371153105 CA6530190	584	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6530189 rs558162340	587	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs558162340 CA384500656	587	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA6530188 rs773116436	588	P>Q		No	ClinGen ExAC
CA236444516 rs985199805	589	D>V		No	ClinGen Ensembl
CA384500632 rs1328244447	590	V>G		No	ClinGen gnomAD
rs771880756 CA6530187	592	N>K		No	ClinGen ExAC TOPMed gnomAD
CA236444491 rs866887339	592	N>S		No	ClinGen Ensembl
rs778745026 CA6530185	595	V>I		No	ClinGen ExAC gnomAD
TCGA novel	596	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384500565 rs1415961454	600	D>G		No	ClinGen TOPMed gnomAD
rs1167224892 CA384500552	602	Y>H		No	ClinGen TOPMed gnomAD
CA384500543 rs1475716668	603	I>V		No	ClinGen gnomAD
CA6530183 rs745956387	604	E>K		No	ClinGen ExAC gnomAD
CA384500518 rs1183215669	605	K>E		No	ClinGen gnomAD
rs1479466540 CA384500515	605	K>R		No	ClinGen gnomAD
rs1232624290 CA384500507	606	E>G		No	ClinGen gnomAD
CA384500490 rs1592466713	608	P>L		No	ClinGen Ensembl
rs1258712798 CA384500478	610	L>P		No	ClinGen TOPMed
rs185968381 CA6530163	611	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs896302007 CA236443727	613	E>Q		No	ClinGen TOPMed gnomAD
rs1213690888 CA384500455	614	I>L		No	ClinGen gnomAD
CA6530162 rs768580885	616	Q>R		No	ClinGen ExAC gnomAD
rs1056339207 CA236443726	617	R>T		No	ClinGen TOPMed gnomAD
rs781302023 CA6530160	619	S>F		No	ClinGen ExAC gnomAD
rs745940783 CA6530161	619	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6530158 rs747216184	621	L>V		No	ClinGen ExAC gnomAD
rs758733529 CA6530156	622	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1394513348 CA384500399	623	R>G		No	ClinGen TOPMed gnomAD
rs1166330893 CA384500395	623	R>M		No	ClinGen gnomAD
CA6530155 rs753008678	625	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA6530153 rs201840394	626	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs779558901 CA6530154	626	M>T		No	ClinGen ExAC TOPMed gnomAD
CA384500359 rs1592466631	628	V>G		No	ClinGen Ensembl
rs1332161528 CA384500352	629	M>I		No	ClinGen TOPMed
CA236443677 rs757944993	629	M>T		No	ClinGen Ensembl
CA6530152 rs753375734	631	M>T		No	ClinGen ExAC
rs369232178 CA236443676	634	T>A		No	ClinGen Ensembl
CA6530151 rs372539547	635	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA384500294 rs1193511328	637	K>N		No	ClinGen gnomAD
CA384618573 rs1185357236	639	A>V		No	ClinGen gnomAD
rs772250615 CA6530135	640	R>C		No	ClinGen ExAC TOPMed gnomAD
rs201603359 CA6530134	640	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA384618567 rs201603359	640	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6530133 rs779468601	641	A>T		No	ClinGen ExAC gnomAD
rs922562021 CA237131316	646	I>V		No	ClinGen Ensembl
CA6530132 rs755509985	647	D>G		No	ClinGen ExAC gnomAD
rs1277842487 CA384618499	650	G>E		No	ClinGen gnomAD
CA6530131 rs754355096	653	D>E		No	ClinGen ExAC gnomAD
rs780726964 CA6530130	654	S>G		No	ClinGen ExAC TOPMed gnomAD
CA384618464 rs1303309136	655	S>C		No	ClinGen gnomAD
rs767190780 CA6530127	657	E>K		No	ClinGen ExAC TOPMed gnomAD
rs756914994 CA6530126	658	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1565711081 CA384618445	658	E>G		No	ClinGen Ensembl
rs200781166 CA6530125	660	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA384618433 rs1398782180	660	K>R		No	ClinGen TOPMed
rs1373256764 CA384618418	662	R>T		No	ClinGen gnomAD
rs762762381 CA384618405	664	G>C		No	ClinGen ExAC TOPMed gnomAD
rs762762381 CA6530123	664	G>R		No	ClinGen ExAC TOPMed gnomAD
rs762762381 CA384618406	664	G>S		No	ClinGen ExAC TOPMed gnomAD
CA384618398 rs1454728270	665	G>V		No	ClinGen TOPMed

No associated diseases with Q9H6T3

9 regional properties for Q9H6T3

Type	Name	Position	InterPro Accession
repeat	Tetratricopeptide repeat 1	133 - 166	IPR001440-1
repeat	Tetratricopeptide repeat 1	202 - 234	IPR001440-2
repeat	Tetratricopeptide repeat	133 - 166	IPR019734-1
repeat	Tetratricopeptide repeat	167 - 200	IPR019734-2
repeat	Tetratricopeptide repeat	201 - 234	IPR019734-3
repeat	Tetratricopeptide repeat	282 - 315	IPR019734-4
repeat	Tetratricopeptide repeat	316 - 349	IPR019734-5
repeat	Tetratricopeptide repeat	350 - 383	IPR019734-6
domain	RNA-polymerase II-associated protein 3-like, C-terminal domain	546 - 636	IPR025986

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chaperone complex	A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
R2TP complex	A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
RPAP3/R2TP/prefoldin-like complex	A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9D706	Rpap3	RNA polymerase II-associated protein 3	Mus musculus (Mouse)	PR
Q68FQ7	Rpap3	RNA polymerase II-associated protein 3	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MTSANKAIEL	QLQVKQNAEE	LQDFMRDLEN	WEKDIKQKDM	ELRRQNGVPE	ENLPPIRNGN
70	80	90	100	110	120
FRKKKKGKAK	ESSKKTREEN	TKNRIKSYDY	EAWAKLDVDR	ILDELDKDDS	THESLSQESE
130	140	150	160	170	180
SEEDGIHVDS	QKALVLKEKG	NKYFKQGKYD	EAIDCYTKGM	DADPYNPVLP	TNRASAYFRL
190	200	210	220	230	240
KKFAVAESDC	NLAVALNRSY	TKAYSRRGAA	RFALQKLEEA	KKDYERVLEL	EPNNFEATNE
250	260	270	280	290	300
LRKISQALAS	KENSYPKEAD	IVIKSTEGER	KQIEAQQNKQ	QAISEKDRGN	GFFKEGKYER
310	320	330	340	350	360
AIECYTRGIA	ADGANALLPA	NRAMAYLKIQ	KYEEAEKDCT	QAILLDGSYS	KAFARRGTAR
370	380	390	400	410	420
TFLGKLNEAK	QDFETVLLLE	PGNKQAVTEL	SKIKKELIEK	GHWDDVFLDS	TQRQNVVKPI
430	440	450	460	470	480
DNPPHPGSTK	PLKKVIIEET	GNLIQTIDVP	DSTTAAAPEN	NPINLANVIA	ATGTTSKKNS
490	500	510	520	530	540
SQDDLFPTSD	TPRAKVLKIE	EVSDTSSLQP	QASLKQDVCQ	SYSEKMPIEI	EQKPAQFATT
550	560	570	580	590	600
VLPPIPANSF	QLESDFRQLK	SSPDMLYQYL	KQIEPSLYPK	LFQKNLDPDV	FNQIVKILHD
610	620	630	640	650	660
FYIEKEKPLL	IFEILQRLSE	LKRFDMAVMF	MSETEKKIAR	ALFNHIDKSG	LKDSSVEELK

KRYGG