Q68FQ7

PR
Gene name
Rpap3
Protein name
RNA polymerase II-associated protein 3
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:300189
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q68FQ7

Entry ID Method Resolution Chain Position Source
AF-Q68FQ7-F1 Predicted AlphaFoldDB

No variants for Q68FQ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q68FQ7

No associated diseases with Q68FQ7

9 regional properties for Q68FQ7

Type Name Position InterPro Accession
repeat Tetratricopeptide repeat 1 133 - 166 IPR001440
repeat Tetratricopeptide repeat 2 202 - 234 IPR013105
repeat Tetratricopeptide repeat 133 - 166 IPR019734-1
repeat Tetratricopeptide repeat 167 - 200 IPR019734-2
repeat Tetratricopeptide repeat 201 - 234 IPR019734-3
repeat Tetratricopeptide repeat 282 - 315 IPR019734-4
repeat Tetratricopeptide repeat 316 - 349 IPR019734-5
repeat Tetratricopeptide repeat 350 - 383 IPR019734-6
domain RNA-polymerase II-associated protein 3-like, C-terminal domain 539 - 629 IPR025986

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chaperone complex A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
R2TP complex A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
RPAP3/R2TP/prefoldin-like complex A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H6T3 RPAP3 RNA polymerase II-associated protein 3 Homo sapiens (Human) PR
Q9D706 Rpap3 RNA polymerase II-associated protein 3 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTSTSKAVEL QLQVKHNAEE LQDFMRDLEH WEKTMRQKDL ELRRQSGVPE ENLPPIRNGS
70 80 90 100 110 120
FRKKKKRKTK DSSKKTKEEN TKNRIKSFDY DAWAKLDVDS ILDELDKEDS THDSVSQESE
130 140 150 160 170 180
SDEDGVRVDS QKALVLKEKG NKYFKQGKYD EAIECYTKGM DADPYNPVLP TNRASAYFRL
190 200 210 220 230 240
KKFAVAESDC NLAIALSRSY TKAYARRGAA RFALQKLEDA RKDYVKVLEL EPDNFEATNE
250 260 270 280 290 300
LRKIDQALTS KENSHPKDIA AVIKPAEGER KANEDQRGRQ KAIAEKDLGN GFFKEGKYEQ
310 320 330 340 350 360
AIECYTRGIA ADSTNALLPA NRAMAYLKVQ KYEEAERDCT QAILLDGSYS KAFARRGTAR
370 380 390 400 410 420
TFLGKINEAK QDFETVLLLE PGNKQAVTEL SRIKKELIEK GRWDDVFLDS TQRHNVVKPV
430 440 450 460 470 480
DSPHRGSPKA LKKVFIEETG NLIESVDAPE SSATVPESDR AAVAVDTGRK KDFSQGDSVS
490 500 510 520 530 540
SGETPRAKVL KIEAVGDSSA PQAQVDVKQG VRQSVSEKTS VRVAQTPGQL AAVVLPPVPA
550 560 570 580 590 600
NSFQLESDFR QLRSSPEMLY QYVKKIEPSL YPKLFQKNLD PDVFNQIIKI LHDFYVEREK
610 620 630 640 650
PALIFEVLER LSQLRRFDMA VMFMSGTERE LTKVLFNHLE KSELKEDSVE ELKKRYGGG