Q9D706
Gene name |
Rpap3 (D15Ertd682e) |
Protein name |
RNA polymerase II-associated protein 3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71919 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D706
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D706-F1 | Predicted | AlphaFoldDB |
48 variants for Q9D706
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs255857844 | 48 | V>I | No | EVA | |
| rs3389365047 | 62 | R>I | No | EVA | |
| rs3413117691 | 83 | K>E | No | EVA | |
| rs3389388146 | 107 | D>V | No | EVA | |
| rs3389356276 | 119 | E>D | No | EVA | |
| rs3389376134 | 130 | D>E | No | EVA | |
| rs3412804509 | 132 | Q>R | No | EVA | |
| rs3389387484 | 143 | K>T | No | EVA | |
| rs3389304211 | 148 | G>* | No | EVA | |
| rs3406521348 | 224 | D>E | No | EVA | |
| rs256754909 | 258 | G>R | No | EVA | |
| rs244545647 | 269 | A>G | No | EVA | |
| rs257780758 | 270 | G>V | No | EVA | |
| rs3389400942 | 271 | E>K | No | EVA | |
| rs221640220 | 273 | K>R | No | EVA | |
| rs259773419 | 315 | R>C | No | EVA | |
| rs212206454 | 328 | Y>F | No | EVA | |
| rs3389391461 | 339 | R>G | No | EVA | |
| rs3389356263 | 343 | Q>L | No | EVA | |
| rs3389347257 | 346 | V>I | No | EVA | |
| rs3389380055 | 358 | R>T | No | EVA | |
| rs3389347286 | 375 | F>VSDG* | No | EVA | |
| rs3389395835 | 377 | T>N | No | EVA | |
| rs3389304228 | 382 | E>G | No | EVA | |
| rs3389378900 | 385 | N>K | No | EVA | |
| rs3389380060 | 386 | K>* | No | EVA | |
| rs51306091 | 404 | H>R | No | EVA | |
| rs3389356292 | 427 | R>W | No | EVA | |
| rs3389400921 | 429 | S>Y | No | EVA | |
| rs248896203 | 453 | S>N | No | EVA | |
| rs227478738 | 455 | A>T | No | EVA | |
| rs3389365105 | 477 | E>D | No | EVA | |
| rs250920143 | 483 | A>T | No | EVA | |
| rs3413126602 | 495 | E>K | No | EVA | |
| rs261077426 | 508 | G>E | No | EVA | |
| rs238343675 | 512 | D>G | No | EVA | |
| rs31987012 | 523 | V>M | No | EVA | |
| rs3389356299 | 526 | E>G | No | EVA | |
| rs32269992 | 528 | M>T | No | EVA | |
| rs257166010 | 536 | G>V | No | EVA | |
| rs3389383470 | 570 | P>S | No | EVA | |
| rs3389380019 | 571 | S>Y | No | EVA | |
| rs3389383411 | 573 | Y>F | No | EVA | |
| rs219447884 | 588 | Q>H | No | EVA | |
| rs3389395819 | 637 | L>S | No | EVA | |
| rs3389388167 | 647 | K>N | No | EVA | |
| rs3389356320 | 648 | E>K | No | EVA | |
| rs239547493 | 649 | D>E | No | EVA |
No associated diseases with Q9D706
9 regional properties for Q9D706
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Tetratricopeptide repeat 1 | 134 - 167 | IPR001440-1 |
| repeat | Tetratricopeptide repeat 1 | 203 - 235 | IPR001440-2 |
| repeat | Tetratricopeptide repeat | 134 - 167 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 168 - 201 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 202 - 235 | IPR019734-3 |
| repeat | Tetratricopeptide repeat | 284 - 317 | IPR019734-4 |
| repeat | Tetratricopeptide repeat | 318 - 351 | IPR019734-5 |
| repeat | Tetratricopeptide repeat | 352 - 385 | IPR019734-6 |
| domain | RNA-polymerase II-associated protein 3-like, C-terminal domain | 541 - 631 | IPR025986 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chaperone complex | A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| R2TP complex | A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. |
| RPAP3/R2TP/prefoldin-like complex | A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSASKAVEL | QLQVKHNAEE | LQDFMRDLEH | WEKDMKEKDL | ELRRQGGVAE | ENLPPIRNGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FRKKKKKGKA | KESSRKTKEE | NTKNRIKSYD | YDAWAKLDVD | RILDELDKED | STHDSLSQES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESDEDGIRVD | SQKALVLKEK | GNKYFKQGKY | DEAIECYTKG | MDADPYNPVL | PTNRASAYFR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKKFAVAESD | CNLAIALSRT | YTKAYARRGA | ARFALQKLED | ARKDYEKVLE | LEPDNFEATN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELRKINQALT | SKENSGPGAA | AAAESKPAAG | ESKPTGGQQG | RQKAIAEKDL | GNGFFKEGKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EQAIECYTRG | IAADRTNALL | PANRAMAYLK | IQRYEEAERD | CTQAIVLDGS | YSKAFARRGT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARTFLGKINE | AKQDFETVLL | LEPGNKQAAT | ELSRIKKELI | EKGHWDDVFL | DSTQRHHVVK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AVDNPPRGSP | KALKKVFIEE | TGNLIETVDA | PDSSATVPES | DRATAAVGTG | TKKNPSEGVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LPAGDRPRAK | VLKIEAVSDT | SAPQAQVGVK | QDARQPGSEK | ASVRAEQMPG | QLAAAGLPPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PANSFQLESD | FRQLRSSPEM | LYQYVKNIEP | SLYPKLFQKN | LDPDVFNQII | KILHDFYIER |
| 610 | 620 | 630 | 640 | 650 | |
| EKPALIFEVL | ERLSQLRRFD | MAVMFMSGPE | RKLTNVLFNH | LEKSDLKEDS | VEELKKRYGG |