Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9GS00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9GS00-F1 | Predicted | AlphaFoldDB |
No variants for Q9GS00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9GS00 | |||||
No associated diseases with Q9GS00
6 regional properties for Q9GS00
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Elongation factor EFG, domain V-like | 459 - 542 | IPR000640 |
| domain | Translational (tr)-type GTP-binding domain | 55 - 235 | IPR000795 |
| domain | Small GTP-binding protein domain | 57 - 224 | IPR005225 |
| domain | GTP-binding protein LepA, C-terminal | 548 - 653 | IPR013842 |
| conserved_site | Tr-type G domain, conserved site | 94 - 109 | IPR031157 |
| domain | Elongation factor 4, domain IV | 461 - 540 | IPR035654 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle switching | The process in which a cell switches cell cycle mode. |
| negative regulation of ubiquitin protein ligase activity | Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. |
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. |
| regulation of oogenesis | Any process that modulates the frequency, rate or extent of oogenesis. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q13098 | GPS1 | COP9 signalosome complex subunit 1 | Homo sapiens (Human) | PR |
| Q99LD4 | Gps1 | COP9 signalosome complex subunit 1 | Mus musculus (Mouse) | PR |
| P97834 | Gps1 | COP9 signalosome complex subunit 1 | Rattus norvegicus (Rat) | PR |
| Q20585 | rpn-7 | 26S proteasome non-ATPase regulatory subunit 6 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQNELLDDPM | DTGAPAAEAA | AADEPLPPAH | GIDREVTPKP | AGNPDLMQQS | LDNPAIPMHL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IEKRDDRRES | CDDGYSLTVN | ESAIDIESLA | CSYDSNAFFL | RARFIARHCP | ILRADAYISL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INYLKEHTTD | ITHYVAFFNE | LESELARKEF | KNRQLNFQIP | LRDQKWIEEN | GATWQSTTDQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQAEYKRHKD | EGVKESTRRA | MEDLFQHYMM | AGKIDEAIRL | YSRGIRDYCT | QLKHSINMWI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NWMEVAICAN | DWGKLDTVTN | TAYRSLKDAD | DAEKNSQQSQ | QAPPQRGENA | PYMVERDPNA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PIQTLTNRQL | IETALAKCLA | AQVLLKLRNK | RYSQVVETIL | QIKTECLQSK | WFVTSSDLGI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YGMLSAMATM | SRADLKLQVS | GNGTFRKLLE | SEPQLIELLG | SYTSSRFGRC | FEIMRSVKPR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLLDPFISRN | VDELFEKIRQ | KCVLQYLQPY | STIKMATMAE | AVGMSSAELQ | LSLLELIEQK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HVSLKIDQNE | GIVRILDERD | ENAILKRVNV | TCDRATQKAK | SLLWKTTLAG | ANIHSISDKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TRPKRKNQKE | SAKFDRNFGG | IDVDEDPRGI | AGPSGLSDDF | NIAYDQQPQQ | QVQYLEDLGD |
| I |