Q99LD4

PR
Gene name
Gps1 (Cops1, Csn1)
Protein name
COP9 signalosome complex subunit 1
Names
SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

414-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99LD4

Entry ID Method Resolution Chain Position Source
AF-Q99LD4-F1 Predicted AlphaFoldDB

No variants for Q99LD4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q99LD4

No associated diseases with Q99LD4

2 regional properties for Q99LD4

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 249 - 423 IPR000717
domain 26S proteasome regulatory subunit Rpn7, N-terminal 107 - 288 IPR045135

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q13098 GPS1 COP9 signalosome complex subunit 1 Homo sapiens (Human) PR
P97834 Gps1 COP9 signalosome complex subunit 1 Rattus norvegicus (Rat) PR
Q9GS00 csn-1 COP9 signalosome complex subunit 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MQIDVDPQED PQNAPDVNYV VENPTLDLEQ YAASYSGLMR IERLQFIADR CPPLRVEALK
70 80 90 100 110 120
MALSFVQRTF NVDMYEEIHR KLSEATRELQ NAPDAIPESG VEPPPLDTAW VEATRKKALL
130 140 150 160 170 180
KLEKLDTDLK NYKGNSIKES IRRGHDDLGD HYLDCGDLSN ALKCYSRARD YCTSAKHVIN
190 200 210 220 230 240
MCLNVIKVSV YLQNWSHVLS YVSKAESTPE IAEQRGERDS QTQAILTKLK CAAGLAELAA
250 260 270 280 290 300
RKYKQAAKCF LLASFDHCDF PELLSPSNVA VYGGLCALAT FDRQELQRNV ISSSSFKLFL
310 320 330 340 350 360
ELEPQVRDII FKFYESKYAS CLKMLDEMKD NLLLDMYLAP HVRTLYTQIR NRALIQYFSP
370 380 390 400 410 420
YVSADMHKMA AAFNTTVAAL EDELTQLILE GLINARIDSH SKILYARDVD QRSTTFEKSL
430 440 450 460 470
LMGKEFQRRA KAMILRAAVL RNQIHVKSPP REGSQGELTP ANSQSRMSTN M