AiPD: Autoinhibited Protein Database

Gene name	FTSH11 (At5g53170, MFH8.11)
Protein name	ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial
Names	AtFTSH11
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G53170
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

80-157 (Predicted disordered autoinhibitory region) PR

80-157 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9FGM0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH03419196	25	P>S	No	1000Genomes
ENSVATH12733129	28	F>L	No	1000Genomes
ENSVATH07407405	43	F>L	No	1000Genomes
tmp_5_21567770_G_T	51	H>Q	No	1000Genomes
ENSVATH12733128	52	N>S	No	1000Genomes
ENSVATH07407403	68	A>T	No	1000Genomes
tmp_5_21567651_A_G	91	L>S	No	1000Genomes
tmp_5_21567604_C_G	107	V>L	No	1000Genomes
tmp_5_21567592_C_T	111	E>K	No	1000Genomes
ENSVATH07407402	118	E>D	No	1000Genomes
tmp_5_21567562_C_T	121	V>I	No	1000Genomes
tmp_5_21567529_C_T	132	D>N	No	1000Genomes
ENSVATH07407401	134	K>E	No	1000Genomes
tmp_5_21567358_C_T	189	D>N	No	1000Genomes
tmp_5_21567313_T_G	204	I>L	No	1000Genomes
ENSVATH07407399	249	P>S	No	1000Genomes
ENSVATH07407392	268	D>E	No	1000Genomes
tmp_5_21566723_C_A	272	V>L	No	1000Genomes
tmp_5_21566506_C_T	311	V>M	No	1000Genomes
tmp_5_21566327_C_T	318	G>S	No	1000Genomes
tmp_5_21565416_C_T	420	G>E	No	1000Genomes
ENSVATH12733091	546	M>L	No	1000Genomes
ENSVATH07407369	722	V>F	No	1000Genomes
tmp_5_21563296_A_C	753	S>A	No	1000Genomes
tmp_5_21563100_G_A	782	R>C	No	1000Genomes
tmp_5_21563052_G_C	798	Q>E	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Peptidase M41	608 - 783	IPR000642
domain	AAA+ ATPase domain	394 - 529	IPR003593
domain	ATPase, AAA-type, core	398 - 526	IPR003959
conserved_site	ATPase, AAA-type, conserved site	497 - 515	IPR003960
domain	AAA ATPase, AAA+ lid domain	549 - 590	IPR041569

		Description
EC Number
Subcellular Localization	Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side Plastid, chloroplast thylakoid membrane; Single-pass membrane protein; Stromal side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope	The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast thylakoid	Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
chloroplast thylakoid membrane	The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plastid	Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent peptidase activity	Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.
metal ion binding	Binding to a metal ion.
metalloendopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Name	Definition
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
PSII associated light-harvesting complex II catabolic process	The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II.
response to heat	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O88967	Yme1l1	ATP-dependent zinc metalloprotease YME1L1	Mus musculus (Mouse)	PR
Q8LQJ8	FTSH5	ATP-dependent zinc metalloprotease FTSH 5, mitochondrial	Oryza sativa subsp japonica (Rice)	PR
A2ZVG7	FTSH9	ATP-dependent zinc metalloprotease FTSH 9, chloroplastic/mitochondrial	Oryza sativa subsp japonica (Rice)	PR
O80983	FTSH4	ATP-dependent zinc metalloprotease FTSH 4, mitochondrial	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8W585	FTSH8	ATP-dependent zinc metalloprotease FTSH 8, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR