O80983

PR
Gene name
FTSH4 (At2g26140, T19L18.5)
Protein name
ATP-dependent zinc metalloprotease FTSH 4, mitochondrial
Names
AtFTSH4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G26140
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

633-717 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O80983

Entry ID Method Resolution Chain Position Source
AF-O80983-F1 Predicted AlphaFoldDB

21 variants for O80983

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_11134672_C_A 10 V>F No 1000Genomes
ENSVATH00248475 13 H>R No 1000Genomes
tmp_2_11134473_C_T 49 R>Q No 1000Genomes
ENSVATH00248472 50 T>M No 1000Genomes
tmp_2_11134465_A_T 52 F>I No 1000Genomes
ENSVATH14554522 63 R>K No 1000Genomes
ENSVATH14554521 100 A>V No 1000Genomes
ENSVATH13410341 106 S>L No 1000Genomes
tmp_2_11134245_C_T 125 R>Q No 1000Genomes
tmp_2_11134233_C_T 129 R>K No 1000Genomes
ENSVATH05595096 158 V>F No 1000Genomes
tmp_2_11133442_C_T 254 R>H No 1000Genomes
tmp_2_11132858_T_A 412 K>M No 1000Genomes
tmp_2_11132420_G_A 558 T>I No 1000Genomes
tmp_2_11132168_T_C 642 Q>R No 1000Genomes
ENSVATH00248462 671 T>A No 1000Genomes
ENSVATH13410331 675 N>K No 1000Genomes
tmp_2_11132039_G_C 685 A>G No 1000Genomes
ENSVATH13410298 698 A>P No 1000Genomes
ENSVATH13410296 699 A>P No 1000Genomes
ENSVATH13410295 700 A>P No 1000Genomes

No associated diseases with O80983

5 regional properties for O80983

Type Name Position InterPro Accession
domain Peptidase M41 474 - 654 IPR000642
domain AAA+ ATPase domain 259 - 395 IPR003593
domain ATPase, AAA-type, core 263 - 392 IPR003959
conserved_site ATPase, AAA-type, conserved site 363 - 381 IPR003960
domain AAA ATPase, AAA+ lid domain 415 - 458 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chloroplast thylakoid Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent peptidase activity Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis.
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

2 GO annotations of biological process

Name Definition
meristem maintenance Any process involved in maintaining the identity, size and shape of a meristem.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O88967 Yme1l1 ATP-dependent zinc metalloprotease YME1L1 Mus musculus (Mouse) PR
A2ZVG7 FTSH9 ATP-dependent zinc metalloprotease FTSH 9, chloroplastic/mitochondrial Oryza sativa subsp japonica (Rice) PR
Q8LQJ8 FTSH5 ATP-dependent zinc metalloprotease FTSH 5, mitochondrial Oryza sativa subsp japonica (Rice) PR
Q9FGM0 FTSH11 ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q8W585 FTSH8 ATP-dependent zinc metalloprotease FTSH 8, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAWRRIITKV SSHERELSSL RSLLVRAYSS FPRVGVTGAV GGGGASLPRT RFQSSYVGSF
70 80 90 100 110 120
ARRVRDREEV NEVAHLRELI RRNDPEAVIR MFESQPSLHA NASALSEYIK ALVKVDRLDQ
130 140 150 160 170 180
SELVRTLQRG IAGVAREEET FGGLGAFRNV GKPTKDGVLG TASAPIHTIS TERTHFKEQL
190 200 210 220 230 240
WSTIRTIGVG FLLISGIGAL IEDRGIGKGL GLHEEVQPSM DSSTKFSDVK GVDEAKAELE
250 260 270 280 290 300
EIVHYLRDPK RFTRLGGKLP KGVLLVGPPG TGKTMLARAI AGEAGVPFFS CSGSEFEEMF
310 320 330 340 350 360
VGVGARRVRD LFSAAKKCSP CIIFIDEIDA IGGSRNPKDQ QYMKMTLNQM LVELDGFKQN
370 380 390 400 410 420
EGIIVVAATN FPESLDKALV RPGRFDRHIV VPNPDVEGRR QILESHMSKV LKAEDVDLMI
430 440 450 460 470 480
IARGTPGFSG ADLANLVNVA ALKAAMDGSK DVTMSDLEFA KDRIMMGSER KSAVISDESR
490 500 510 520 530 540
KLTAFHEGGH ALVAIHTEGA LPVHKATIVP RGMALGMVSQ LPDKDETSIS RKQMLARLDV
550 560 570 580 590 600
CMGGRVAEEL IFGESEVTSG ASSDLEQATK LARAMVTKFG MSKEVGLVAH NYDDNGKSMS
610 620 630 640 650 660
TETRLLIESE VKQLLEKAYN NAKTILTVYN KELHALANAL LQHETLSGKQ IKELLTDLNS
670 680 690 700 710
PLLQKRQEVV TKQSNPVPPS TPSSASSAAA AAAAAAAAAA AAAATAATKG KDMAPVS