O88967
PR
Gene name |
Yme1l1 |
Protein name |
ATP-dependent zinc metalloprotease YME1L1 |
Names |
ATP-dependent metalloprotease FtsH1, YME1-like protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27377 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88967
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88967-F1 | Predicted | AlphaFoldDB |
28 variants for O88967
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs215141265 | 29 | I>T | No | EVA | |
| rs240457152 | 30 | S>C | No | EVA | |
| rs222174932 | 36 | P>S | No | EVA | |
| rs241853508 | 39 | Q>P | No | EVA | |
| rs247964847 | 40 | K>N | No | EVA | |
| rs3388531008 | 76 | M>K | No | EVA | |
| rs3388529791 | 129 | K>I | No | EVA | |
| rs3388533267 | 145 | I>K | No | EVA | |
| rs3388527451 | 157 | T>I | No | EVA | |
| rs3388533280 | 158 | R>G | No | EVA | |
| rs3388533712 | 193 | L>M | No | EVA | |
| rs3388530955 | 195 | K>Q | No | EVA | |
| rs3388529803 | 320 | V>I | No | EVA | |
| rs3388530251 | 374 | P>L | No | EVA | |
| rs3388533632 | 386 | G>C | No | EVA | |
| rs3388526481 | 397 | Y>F | No | EVA | |
| rs3388533291 | 399 | R>G | No | EVA | |
| rs3391333631 | 403 | N>I | No | EVA | |
| rs3391352009 | 406 | L>I | No | EVA | |
| rs3388530978 | 423 | A>T | No | EVA | |
| rs3388533331 | 460 | W>R | No | EVA | |
| rs3388529961 | 491 | L>F | No | EVA | |
| rs3388529885 | 496 | A>T | No | EVA | |
| rs3388534220 | 519 | I>V | No | EVA | |
| rs3388533717 | 521 | M>K | No | EVA | |
| rs3388532783 | 538 | T>R | No | EVA | |
| rs3388527423 | 545 | H>Y | No | EVA | |
| rs3388529947 | 713 | E>G | No | EVA |
No associated diseases with O88967
5 regional properties for O88967
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent peptidase activity | Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. |
| metal ion binding | Binding to a metal ion. |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| mitochondrial protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. |
| mitochondrial protein processing | The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. |
| mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| protein hexamerization | The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. |
| protein quality control for misfolded or incompletely synthesized proteins | The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8LQJ8 | FTSH5 | ATP-dependent zinc metalloprotease FTSH 5, mitochondrial | Oryza sativa subsp japonica (Rice) | PR |
| A2ZVG7 | FTSH9 | ATP-dependent zinc metalloprotease FTSH 9, chloroplastic/mitochondrial | Oryza sativa subsp japonica (Rice) | PR |
| O80983 | FTSH4 | ATP-dependent zinc metalloprotease FTSH 4, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FGM0 | FTSH11 | ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W585 | FTSH8 | ATP-dependent zinc metalloprotease FTSH 8, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFSLSSTVQP | QVTIPLSHLI | NAFHSPKNIS | VSVNTPVSQK | QHRDTVPEHE | APSSEPVLNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDLGLSELKI | GQIDKMVENL | LPGFYKDKRV | SSCWHTSHIS | AQSFFENKYG | HLDMFSTLRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSLYRQHPKT | LRSICSDLQY | FPVFIQSRGF | KTLKSRTRRL | QSTSERLVEA | QNIAPSFVKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLLRDRGTDL | ESLDKLMKTK | NIPEAHQDAF | KTGFAEGFLK | AQALTQKTND | SLRRTRLILF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLLLFGIYGL | LKNPFLSVRF | RTTTGLDSAV | DPVQMKNVTF | EHVKGVEEAK | QELQEVVEFL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KNPQKFTVLG | GKLPKGILLV | GPPGTGKTLL | ARAVAGEADV | PFYYASGSEF | DEMFVGVGAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RIRNLFREAK | ANAPCVIFID | ELDSVGGKRI | ESPMHPYSRQ | TINQLLAEMD | GFKPNEGVII |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IGATNFPEAL | DNALIRPGRF | DMQVTVPRPD | VKGRTEILKW | YLNKIKFDKS | VDPEIIARGT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VGFSGAELEN | LVNQAALKAA | VDGKEMVTMK | ELEFSKDKIL | MGPERRSVEI | DNKNKTITAY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HESGHAIIAY | YTKDAMPINK | ATIMPRGPTL | GHVSLLPEND | RWNETRAQLL | AQMDVSMGGR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VAEELIFGTD | HITTGASSDF | DNATKIAKRM | VTKFGMSEKL | GVMTYSDTGK | LSPETQSAIE |
| 670 | 680 | 690 | 700 | 710 | |
| QEIRILLRES | YERAKHILKT | HAKEHKNLAE | ALLTYETLDA | KEIQIVLEGK | KLEVR |