Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9FFL1

Entry ID Method Resolution Chain Position Source
AF-Q9FFL1-F1 Predicted AlphaFoldDB

36 variants for Q9FFL1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_1682559_C_A 7 P>T No 1000Genomes
tmp_5_1682569_A_C 10 D>A No 1000Genomes
ENSVATH03027016 22 N>H No 1000Genomes
tmp_5_1682629_T_C 30 I>T No 1000Genomes
ENSVATH03027017 39 P>A No 1000Genomes
ENSVATH06927172 61 L>V No 1000Genomes
ENSVATH06927173 103 I>F No 1000Genomes
ENSVATH06927174 107 M>L No 1000Genomes
ENSVATH03027020 115 G>C No 1000Genomes
ENSVATH00607917 123 L>S No 1000Genomes
ENSVATH03027023 125 M>L No 1000Genomes
tmp_5_1682997_C_T 153 L>F No 1000Genomes
tmp_5_1683024_A_T 162 I>L No 1000Genomes
tmp_5_1683141_T_G 201 F>V No 1000Genomes
tmp_5_1683145_C_T 202 S>F No 1000Genomes
ENSVATH10591634 212 M>I No 1000Genomes
ENSVATH06927175 255 T>M No 1000Genomes
ENSVATH00607921 255 T>S No 1000Genomes
ENSVATH06927176 260 N>T No 1000Genomes
ENSVATH10591667 287 G>V No 1000Genomes
tmp_5_1683408_G_A 290 A>T No 1000Genomes
ENSVATH06927177 294 D>A No 1000Genomes
ENSVATH03027026 313 V>A No 1000Genomes
ENSVATH06927179 328 M>L No 1000Genomes
tmp_5_1683528_A_C 330 M>L No 1000Genomes
tmp_5_1683575_G_A 345 M>I No 1000Genomes
ENSVATH10591668 353 E>V No 1000Genomes
ENSVATH00607922 362 R>G No 1000Genomes
ENSVATH00607924 377 I>F No 1000Genomes
ENSVATH10591670 429 V>I No 1000Genomes
ENSVATH13932562 434 P>L No 1000Genomes
tmp_5_1683883_T_G 448 L>R No 1000Genomes
ENSVATH06927181 459 V>L No 1000Genomes
tmp_5_1683924_C_T 462 L>F No 1000Genomes
tmp_5_1683994_T_A 485 L>Q No 1000Genomes
tmp_5_1684007_G_T 489 M>I No 1000Genomes

No associated diseases with Q9FFL1

4 regional properties for Q9FFL1

Type Name Position InterPro Accession
domain Zinc finger, RING-type 18 - 58 IPR001841-1
domain Zinc finger, RING-type 159 - 192 IPR001841-2
domain Drought induced 19 protein type, zinc-binding domain 156 - 216 IPR008598
domain Zinc finger C2HC RNF-type 80 - 112 IPR034734

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
polyamine transmembrane transporter activity Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other.
symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

3 GO annotations of biological process

Name Definition
cadaverine transport The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
polyamine transport The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UPY5 SLC7A11 Cystine/glutamate transporter Homo sapiens (Human) PR
P63115 Slc7a10 Asc-type amino acid transporter 1 Mus musculus (Mouse) PR
Q9QXW9 Slc7a8 Large neutral amino acids transporter small subunit 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTELSSPNLD SASQKPRIST ENPPPPPPHI SIGVTTGDPA TSPARTVNQI KKITVLPLVF
70 80 90 100 110 120
LIFYEVSGGP FGIEDSVKAA GPLLAIVGFI VFPFIWSIPE ALITAEMGTM FPENGGYVVW
130 140 150 160 170 180
VTLAMGPYWG FQQGWVKWLS GVIDNALYPI LFLDYLKSGI PILGSGIPRV AAILVLTVAL
190 200 210 220 230 240
TYLNYRGLSI VGVAAVLLGV FSILPFVVMS FMSIPKLKPS RWLVVSKKMK GVNWSLYLNT
250 260 270 280 290 300
LFWNLNYWDS VSTLTGEVEN PSKTLPRALF YALLLVVFSY IFPVLTGTGA IALDQKLWTD
310 320 330 340 350 360
GYFADIGKVI GGVWLGWWIQ AAAATSNMGM FLAEMSSDSF QLLGMAERGM LPEVFAKRSR
370 380 390 400 410 420
YRTPWVGILF SASGVIILSW LSFQEIVAAE NLLYCFGMVL EFITFVRLRM KYPAASRPFK
430 440 450 460 470 480
IPVGVLGSVL MCIPPTVLIG VIMAFTNLKV ALVSLAAIVI GLVLQPCLKQ VEKKGWLKFS
TSSHLPNLME