AiPD: Autoinhibited Protein Database

Gene name	Slc7a10 (Asc1)
Protein name	Asc-type amino acid transporter 1
Names	Asc-1, D-serine transporter, Solute carrier family 7 member 10
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:53896
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-50 (Predicted disordered autoinhibitory region) PR

1-50 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P63115-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs254497236	16	G>R	No	EVA
rs256404541	17	H>R	No	EVA
rs3388897736	32	P>S	No	EVA
rs3388903114	34	P>L	No	EVA
rs3388883548	93	A>T	No	EVA
rs3388894948	101	E>Q	No	EVA
rs3388897551	110	G>D	No	EVA
rs3388900405	129	L>F	No	EVA
rs3388900423	160	C>S	No	EVA
rs3388897674	163	P>L	No	EVA
rs3388892919	173	A>G	No	EVA
rs3388901355	221	E>D	No	EVA
rs3388888056	225	P>L	No	EVA
rs45660896	230	A>T	No	EVA
rs3388894926	258	N>D	No	EVA
rs3388874721	283	T>S	No	EVA
rs3388892907	290	N>S	No	EVA
rs3388892902	293	Y>*	No	EVA
rs3388906079	298	S>F	No	EVA
rs3388894890	300	Q>P	No	EVA
rs3388888032	319	Y>H	No	EVA
rs3388881132	369	T>S	No	EVA
rs3388897570	372	P>S	No	EVA
rs3388881145	402	Y>N	No	EVA
rs3388883580	413	L>F	No	EVA
rs3388903718	431	L>F	No	EVA
rs3388859892	467	P>S	No	EVA
rs3388881123	470	F>L	No	EVA
rs3388888033	473	V>M	No	EVA
rs3397816144	488	S>T	No	EVA
rs3397825198	489	M>K	No	EVA
rs32072976	491	R>H	No	EVA
rs3413075051	508	E>K	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P63115

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein	Colocalizes with OLIG2 in astrocytic processes (PubMed:34749773) Localizes to the plasma membrane in mature adipocytes and to intracellular structures in preadipocytes (PubMed:33707431)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical dendrite	A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

Name	Definition
L-amino acid transmembrane transporter activity	Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids.
neutral amino acid transmembrane transporter activity	Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3.

Name	Definition
D-alanine transport	The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
D-serine transport	The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
neutral amino acid transport	The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UPY5	SLC7A11	Cystine/glutamate transporter	Homo sapiens (Human)	PR
Q9QXW9	Slc7a8	Large neutral amino acids transporter small subunit 2	Mus musculus (Mouse)	PR
Q9FFL1	RMV1	Polyamine transporter RMV1	Arabidopsis thaliana (Mouse-ear cress)	PR