Q9ESG5

PR
Gene name
Hs3st1 (3ost, 3ost1)
Protein name
Heparan sulfate glucosamine 3-O-sulfotransferase 1
Names
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1, Heparan sulfate 3-O-sulfotransferase 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:84406
EC number
2.8.2.23: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ESG5

Entry ID Method Resolution Chain Position Source
AF-Q9ESG5-F1 Predicted AlphaFoldDB

No variants for Q9ESG5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9ESG5

No associated diseases with Q9ESG5

1 regional properties for Q9ESG5

Type Name Position InterPro Accession
domain Sulfotransferase domain 59 - 298 IPR000863

Functions

Description
EC Number 2.8.2.23 Sulfotransferases
Subcellular Localization
  • Golgi apparatus lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi lumen The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.

1 GO annotations of molecular function

Name Definition
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + -glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.

2 GO annotations of biological process

Name Definition
glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZT8 HS3ST5 Heparan sulfate glucosamine 3-O-sulfotransferase 5 Homo sapiens (Human) PR
Q8BSL4 Hs3st5 Heparan sulfate glucosamine 3-O-sulfotransferase 5 Mus musculus (Mouse) PR
O35310 Hs3st1 Heparan sulfate glucosamine 3-O-sulfotransferase 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTLLLLGAVL LVAQPQLVPS HPAAPGPGLK QQGLLRKVII LPEDTGEGAA TNGSTQQLPQ
70 80 90 100 110 120
TIIIGVRKGG TRALLEMLSL HPDVAAAENE VHFFDWEEHY SQGLGWYLTQ MPFSSPHQLT
130 140 150 160 170 180
VEKTPAYFTS PKVPERIHSM NPTIRLLLIL RDPSERVLSD YTQVLYNHLQ KHKPYPPIED
190 200 210 220 230 240
LLMRDGRLNV DYKALNRSLY HAHMLNWLRF FPLGHIHIVD GDRFIRDPFP EIQKVERFLK
250 260 270 280 290 300
LSPQINASNF YFNKTKGFYC LRDSGKDRCL HESKGRAHPQ VDPKLLDKLH EYFREPNKKF
310
FKLVGRTFDW H