Q8BSL4
Gene name |
Hs3st5 (Hs3ost5) |
Protein name |
Heparan sulfate glucosamine 3-O-sulfotransferase 5 |
Names |
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5, Heparan sulfate 3-O-sulfotransferase 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:319415 |
EC number |
2.8.2.23: Sulfotransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BSL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BSL4-F1 | Predicted | AlphaFoldDB |
11 variants for Q8BSL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389103875 | 5 | Q>H | No | EVA | |
| rs3389097421 | 15 | V>L | No | EVA | |
| rs3389094896 | 45 | S>C | No | EVA | |
| rs3400484535 | 134 | K>M | No | EVA | |
| rs3400953461 | 134 | K>N | No | EVA | |
| rs3401035813 | 134 | K>Q | No | EVA | |
| rs3389099486 | 178 | L>P | No | EVA | |
| rs3389090656 | 190 | I>T | No | EVA | |
| rs3389094861 | 193 | Y>F | No | EVA | |
| rs3389099474 | 216 | D>N | No | EVA | |
| rs3401161745 | 317 | D>E | No | EVA |
No associated diseases with Q8BSL4
1 regional properties for Q8BSL4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sulfotransferase domain | 91 - 335 | IPR000863 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.8.2.23 | Sulfotransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | Catalysis of the reaction: 3'-phosphoadenylyl sulfate + -glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| heparan sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. |
| heparan sulfate proteoglycan biosynthetic process, enzymatic modification | The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. |
| negative regulation of coagulation | Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. |
| protein sulfation | The addition of a sulfate group as an ester to a protein amino acid. |
| regulation of viral entry into host cell | Any process that modulates the frequency, rate or extent of the viral entry into the host cell. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IZT8 | HS3ST5 | Heparan sulfate glucosamine 3-O-sulfotransferase 5 | Homo sapiens (Human) | PR |
| O35310 | Hs3st1 | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | Mus musculus (Mouse) | PR |
| Q9ESG5 | Hs3st1 | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLFKQQVWLR | QKLLVLGSLA | VGSLLYLVAR | VGSLDRLQPI | CPVESRFGGA | HNQAELPLRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQFKRGLLHE | FRKGNSSKEQ | VHLHDLVQQL | PKAIIIGVRK | GGTRALLEML | NLHPAVVKAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QEIHFFDNDE | NYAKGIEWYR | KKMPFSYPQQ | ITIEKSPAYF | ITEEVPERIY | KMNSSIKLLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IVREPTTRAI | SDYTQVLEGK | ERKNKTYYKF | EKLAIDPNTC | EVNTKYKAVR | TSIYTKHLER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WLKYFPIEQF | HIVDGDRLIT | EPLPELQLVE | KFLNLPPRIS | QYNLYFNATR | GFYCLRFNII |
| 310 | 320 | 330 | 340 | ||
| FNKCLAGSKG | RIHPEVDPSV | ITKLRKFFHP | FNQKFYQITG | RTLNWP |