Q9ES46

PR
Gene name
Parvb
Protein name
Beta-parvin
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:170736
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ES46

Entry ID Method Resolution Chain Position Source
AF-Q9ES46-F1 Predicted AlphaFoldDB

11 variants for Q9ES46

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389348994 31 A>V No EVA
rs3389369170 50 I>V No EVA
rs258352743 73 E>Q No EVA
rs225743594 77 I>V No EVA
rs3389342083 157 V>L No EVA
rs3389349011 236 G>S No EVA
rs236871531 291 L>I No EVA
rs3406343731 317 V>E No EVA
rs3389371854 324 F>L No EVA
rs3389385617 333 K>* No EVA
rs3406408232 337 A>G No EVA

No associated diseases with Q9ES46

2 regional properties for Q9ES46

Type Name Position InterPro Accession
domain Calponin homology domain 88 - 195 IPR001715-1
domain Calponin homology domain 255 - 362 IPR001715-2

Functions

Description
EC Number
Subcellular Localization
  • Cell junction, focal adhesion
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm, cytoskeleton
  • Cell projection, lamellipodium
  • Cytoplasm, myofibril, sarcomere
  • Cytoplasm, myofibril, sarcomere, Z line
  • Constituent of focal adhesions
  • Detected at the tips of the leading edge of cells
  • Colocalizes with F-actin at the tips of lamellipodia (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

1 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.

6 GO annotations of biological process

Name Definition
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
establishment or maintenance of cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.
lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
substrate adhesion-dependent cell spreading The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HBI1 PARVB Beta-parvin Homo sapiens (Human) PR
Q9ERD8 Parvg Gamma-parvin Mus musculus (Mouse) PR
O16785 pat-6 Paralyzed arrest at two-fold protein 6 Caenorhabditis elegans PR
10 20 30 40 50 60
MSSAPPRSPT PRAPKMKKDE SFLGKLGGTL ARKKKTREVT DLQEEGKSAI NSPMAPALVD
70 80 90 100 110 120
IHPEDTQLEE NEERTMIDPT SREDPKFKEL VKVLLDWIND VLAEERIIVK QLEEDLYDGQ
130 140 150 160 170 180
VLQKLLEKLA HCKLNVAEVT QSEIGQKQKL QTVLEAVQDL LRPHGWPLRW NVDSIHGKNL
190 200 210 220 230 240
VAILHLLVSL AMHFRAPIHL PEHVTVQVVV VRKREGLLHS SHISEELTTT TEIMMGRFER
250 260 270 280 290 300
DAFDTLFDHA PDKLNLVKKS LITFVNKHLN KLNLEVTDLE TQFADGVYLV LLLGLLEDYF
310 320 330 340 350 360
VPLHNFYLTP DSFDQKVHNV AFAFELMLDG GLKKPKARPE DVVNLDLKST LRVLYTLFTK
YKDVE