AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-132 (Predicted disordered autoinhibitory region) PR

1-132 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9ERD8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389373371	2	E>K	No	EVA
rs31909955	3	L>S	No	EVA
rs3389299126	4	E>D	No	EVA
rs218756813	28	G>E	No	EVA
rs230038582	31	K>R	No	EVA
rs3412988693	63	I>V	No	EVA
rs3405485001	65	V>L	No	EVA
rs242112275	82	F>L	No	EVA
rs1133611334	113	V>I	No	EVA
rs3389299080	148	K>E	No	EVA
rs248610519	149	R>H	No	EVA
rs3389381869	161	Q>H	No	EVA
rs3389379619	167	I>L	No	EVA
rs3389299063	170	T>S	No	EVA
rs3389371872	223	K>M	No	EVA
rs3389342005	259	K>M	No	EVA
rs3389332211	283	K>M	No	EVA
rs3389385641	312	L>I	No	EVA
rs232171105	319	R>K	No	EVA
rs3389373382	326	H>Y	No	EVA

Type	Name	Position	InterPro Accession
domain	Calponin homology domain	44 - 151	IPR001715-1
domain	Calponin homology domain	210 - 317	IPR001715-2

		Description
EC Number
Subcellular Localization	Cell junction, focal adhesion Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasm, cytoskeleton	Constituent of focal adhesions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.

Name	Definition
actin cytoskeleton reorganization	A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
cell projection assembly	Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
establishment or maintenance of cell polarity	Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
substrate adhesion-dependent cell spreading	The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9HBI1	PARVB	Beta-parvin	Homo sapiens (Human)	PR
Q9ES46	Parvb	Beta-parvin	Mus musculus (Mouse)	PR
O16785	pat-6	Paralyzed arrest at two-fold protein 6	Caenorhabditis elegans	PR