Q9DCT2

PR
Gene name
Ndufs3
Protein name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Names
Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68349
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for Q9DCT2

Entry ID Method Resolution Chain Position Source
6G2J EM 330 A C 1-263 PDB
6G72 EM 390 A C 1-263 PDB
6ZR2 EM 310 A C 1-263 PDB
6ZTQ EM 300 A C 1-263 PDB
7AK5 EM 317 A C 1-263 PDB
7AK6 EM 382 A C 1-263 PDB
7B93 EM 304 A C 1-263 PDB
7PSA EM 340 A C 1-263 PDB
8C2S EM 390 A C 1-263 PDB
8CA3 EM 320 A C 1-263 PDB
8CA5 EM 390 A C 1-263 PDB
8OLT EM 284 A C 1-263 PDB
8OM1 EM 239 A C 1-263 PDB
AF-Q9DCT2-F1 Predicted AlphaFoldDB

12 variants for Q9DCT2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs250165435 23 A>P No EVA
rs3391904022 30 W>* No EVA
rs3391898979 30 W>R No EVA
rs3391907085 30 W>S No EVA
rs27368610 49 R>W No EVA
rs3388571090 52 V>M No EVA
rs3391886090 65 A>* No EVA
rs3388565084 95 T>M No EVA
rs3388566910 108 K>N No EVA
rs3391904012 188 T>P No EVA
rs3388569905 224 E>K No EVA
rs3388565075 249 E>K No EVA

No associated diseases with Q9DCT2

2 regional properties for Q9DCT2

Type Name Position InterPro Accession
domain NADH:ubiquinone oxidoreductase, 30kDa subunit 86 - 206 IPR001268
conserved_site NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site 166 - 187 IPR020396

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.

2 GO annotations of molecular function

Name Definition
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

7 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
proton motive force-driven mitochondrial ATP synthesis The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.
reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23709 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Bos taurus (Bovine) PR
Q0MQG8 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Pan troglodytes (Chimpanzee) PR
O75489 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MAAAAARVWC RGLLGAASVG RGAGRPSVLW QHVRRESAAA DKRPTVRPRS DVTHKQLSAF
70 80 90 100 110 120
GEYVAEILPK YVQQVQVSCL DELEICIHPD GVIPTLTFLR DHTNAQFKSL ADLTAVDVPT
130 140 150 160 170 180
RQNRFEIVYN LLSLRFNSRI RVKTYADELT PIDSIVSVHI AANWYEREVW DMFGVFFFNH
190 200 210 220 230 240
PDLRRILTDY GFEGHPFRKD FPLTGYVELR YDDEVKRVVA EPVELAQEFR KFDLNSPWEA
250 260
FPAYRQPPES LKLEAGDKKP ETK