AiPD: Autoinhibited Protein Database

Gene name	NDUFS3
Protein name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Names	Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit
Species	Bos taurus (Bovine)
KEGG Pathway	bta:287327
EC number	7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-84 (Predicted disordered autoinhibitory region) PR

1-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5LC5	EM	435 A	C	46-251	PDB
5LDW	EM	427 A	C	39-266	PDB
5LDX	EM	560 A	C	39-266	PDB
5O31	EM	413 A	C	39-266	PDB
7DGQ	EM	500 A	C	39-266	PDB
7DGR	EM	460 A	C	39-266	PDB
7DGS	EM	780 A	C	39-266	PDB
7DGZ	EM	380 A	C	39-266	PDB
7DH0	EM	420 A	C	39-266	PDB
7DKF	EM	830 A	C2	39-266	PDB
7QSD	EM	310 A	C	1-266	PDB
7QSK	EM	284 A	C	1-266	PDB
7QSL	EM	276 A	C	1-266	PDB
7QSM	EM	230 A	C	1-266	PDB
7QSN	EM	281 A	C	1-266	PDB
7QSO	EM	302 A	C	1-266	PDB
7R41	EM	230 A	C	1-266	PDB
7R42	EM	230 A	C	1-266	PDB
7R43	EM	240 A	C	1-266	PDB
7R44	EM	240 A	C	1-266	PDB
7R45	EM	240 A	C	1-266	PDB
7R46	EM	240 A	C	1-266	PDB
7R47	EM	230 A	C	1-266	PDB
7R48	EM	230 A	C	1-266	PDB
7R4C	EM	230 A	C	1-266	PDB
7R4D	EM	230 A	C	1-266	PDB
7R4F	EM	240 A	C	1-266	PDB
7R4G	EM	250 A	C	1-266	PDB
AF-P23709-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P23709

Type	Name	Position	InterPro Accession
domain	NADH:ubiquinone oxidoreductase, 30kDa subunit	89 - 209	IPR001268
conserved_site	NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site	169 - 190	IPR020396

		Description
EC Number	7.1.1.2	Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization	Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial respiratory chain complex I	A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

Name	Definition
NADH dehydrogenase (ubiquinone) activity	Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
NADH dehydrogenase activity	Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

Name	Definition
mitochondrial electron transport, NADH to ubiquinone	The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly	The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of intrinsic apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
reactive oxygen species metabolic process	The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0MQG8	NDUFS3	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	Pan troglodytes (Chimpanzee)	PR
O75489	NDUFS3	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	Homo sapiens (Human)	PR
Q9DCT2	Ndufs3	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	Mus musculus (Mouse)	PR