Q0MQG8

PR
Gene name
NDUFS3
Protein name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Names
Complex I-30kD, CI-30kD, NADH-ubiquinone oxidoreductase 30 kDa subunit
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
ptr:451175
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0MQG8

Entry ID Method Resolution Chain Position Source
AF-Q0MQG8-F1 Predicted AlphaFoldDB

No variants for Q0MQG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0MQG8

No associated diseases with Q0MQG8

2 regional properties for Q0MQG8

Type Name Position InterPro Accession
domain NADH:ubiquinone oxidoreductase, 30kDa subunit 87 - 207 IPR001268
conserved_site NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site 167 - 188 IPR020396

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

2 GO annotations of molecular function

Name Definition
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

5 GO annotations of biological process

Name Definition
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23709 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Bos taurus (Bovine) PR
O75489 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Homo sapiens (Human) PR
Q9DCT2 Ndufs3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR NDVAHKQLSA
70 80 90 100 110 120
FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL RDHTNAQFKS LVDLTAVDVP
130 140 150 160 170 180
TRQNRFEIVY NLLSLRFNSR IRVKTYTDEL TPIESAVSVF KAANWYEREI WDMFGVFFAN
190 200 210 220 230 240
HPDLRRILTD YGFEGHPFRK DFPLSGYVEL RYDDEVKRVV AEPVELAQEF RKFDLNSPWE
250 260
AFPVYRQPPE SLKLEAGDKN LMPN