AiPD: Autoinhibited Protein Database

Gene name	Scyl3 (Pace1)
Protein name	Protein-associating with the carboxyl-terminal domain of ezrin
Names	Ezrin-binding protein PACE-1, SCY1-like protein 3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:240880
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

399-683 (Predicted disordered autoinhibitory region) PR

399-683 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DBQ7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388511607	24	L>R	No	EVA
rs3390906273	29	A>T	No	EVA
rs3388512440	104	I>F	No	EVA
rs3388510634	248	D>E	No	EVA
rs3390938528	258	S>I	No	EVA
rs3390867519	263	S>C	No	EVA
rs3388514358	323	G>E	No	EVA
rs3388513070	325	T>N	No	EVA
rs3388514356	338	V>M	No	EVA
rs3388512142	339	I>L	No	EVA
rs3388512172	340	P>H	No	EVA
rs3388512163	392	I>F	No	EVA
rs3388514402	425	A>S	No	EVA
rs3388510350	451	V>L	No	EVA
rs46098542	457	D>G	No	EVA
rs48581078	457	D>N	No	EVA
rs3388512436	459	S>L	No	EVA
rs48653343	478	R>C	No	EVA
rs48653343	478	R>S	No	EVA
rs3388513018	483	C>W	No	EVA
rs254006804	521	G>S	No	EVA
rs240897855	532	S>N	No	EVA
rs3388512612	541	P>H	No	EVA
rs259032095	546	R>I	No	EVA
rs229196546	552	C>W	No	EVA
rs265686024	571	D>G	No	EVA
rs229695622	572	G>C	No	EVA
rs256009137	573	E>Q	No	EVA
rs211803377	574	A>S	No	EVA
rs46672857	703	L>V	No	EVA
rs247185616	725	G>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	1 - 245	IPR000719

		Description
EC Number
Subcellular Localization	Cytoplasm Golgi apparatus Cell projection, lamellipodium	Colocalized with EZR/VIL2, actin and CD44 in lamellipodia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

Name	Definition
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
neuron development	The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
spinal cord motor neuron differentiation	The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96KG9	SCYL1	N-terminal kinase-like protein	Homo sapiens (Human)	PR
Q5M9F8	Scyl1	N-terminal kinase-like protein	Rattus norvegicus (Rat)	PR