Q5M9F8
Gene name |
Scyl1 |
Protein name |
N-terminal kinase-like protein |
Names |
SCY1-like protein 1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:293684 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5M9F8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5M9F8-F1 | Predicted | AlphaFoldDB |
4 variants for Q5M9F8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3319169235 | 49 | D>V | No | EVA | |
| rs65445415 | 298 | S>I | No | EVA | |
| rs64723692 | 309 | C>W | No | EVA | |
| rs8173323 | 780 | E>* | No | EVA |
No associated diseases with Q5M9F8
1 regional properties for Q5M9F8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 14 - 314 | IPR000719 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cis-Golgi network | The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. |
| COPI vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
| spinal cord motor neuron differentiation | The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWFFARDPVR | DFPFELNPEP | PEGGPPGPWV | LHRGRKKATG | SAVSIFVYDV | KPGAEEQTQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKAAFKRLKT | LRHPNILAYI | DGLETEKCLH | IVTEAVTPLG | TYLKARAEAG | GLKEQELSWG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHQIVKALSF | LVNDCNLIHN | NVCMAAVFVD | KAGEWKLGGL | DYMYSAQGNG | GGPPNKGIPE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEQYDPPELA | DSSSRAVKEK | WSADMWRLGC | LIWEVFNGSL | PRATALRNPG | KIPKSLVTHY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CELVGANPKV | RPNPARFLQN | CRAPGGFMSN | RFVETNLFLE | EIQIKEPAEK | QKFFQELSKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDSFPEDFCR | HKVLPQLLTA | FEFGNAGAVV | LTPLFKVGKF | LSAEEYQQKI | IPVVVKMFSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TDRAMRVRLL | QQMEQFIQYL | DEPTVNTQIF | PHVTHGFLDT | NPAIREQTVK | SMLLLAPKLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ETNLNVELLK | HFARLQAKDD | QGPIRCNTTV | CLGKIGSYLS | ASTRHRVLTS | AFSRATKDPF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| APSRVAGVLG | FAATHNLYSM | DDCAHKILPV | LCGLTVDPEK | SVRDQAFKTI | RSFLSKLESV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEDPTQLAEI | EKDVHAASSP | GTGGAAASWA | GWAVTGVSSL | TSKLIRTHPT | PVPSEAAVPQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RPVPEGDPAP | APAPASATPA | TSGHRETQEE | DKDAAEDSAT | ADRWDDEDWG | SLEQEAESVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AQQDDWSTKG | QGNRAGQVSH | SDHKSLDSHW | SSWEVEGSWD | QGWQEPSSVE | PPPEGTRLAS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EYNWGGAEPS | DKGDPFAALS | VRPSTQPRPD | PDSWGEDNWE | GLEAESRQVK | AELARKKREE |
| 790 | 800 | ||||
| RRREMEAKRA | EKKATKGPMK | LGARKLD |